Osteogenic activity and angiogenesis of a SrTiO<sub>3</sub> nano-gridding structure on titanium surface

Gong, Zheni; Cheng, Haoyan; Zhang, Meng; Liu, Xi; Zeng, Yan; Xiang, Kaiwen; Xu, Yuan; Wang, Yinwei; Zhu, Zhihong

doi:10.1039/c6tb02329k

Cited by 26 publications

(15 citation statements)

References 64 publications

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“…Surface modification of titanium can significantly enhance the osteogenesis and antibacterial efficacy [35][36][37][38]. In this study, we fabricated a novel Zn-incorporated TiO 2 coating by MAO and subsequent hydrothermal treatment producing micro-nano topography on an SLM surface.…”

Section: Discussionmentioning

confidence: 99%

Enhanced Biocompatibility and Antibacterial Activity of Selective Laser Melting Titanium with Zinc-Doped Micro-Nano Topography

et al. 2019

Journal of Nanomaterials

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Selective laser melting (SLM) titanium is a suitable material for use in customized implants. However, long-term implant survival requires both successful osseointegration and promising antibacterial characteristics. Native SLM titanium thus requires proper modifications to improve its bioactivity and antibacterial efficacy. Micro-arc oxidation (MAO) was conducted on sandblasted SLM substrate to form a microporous TiO2 coating. Subsequently, hydrothermal treatment was applied to fabricate micro-nano zinc-incorporated coatings with different Zn content (1 mM-Zn and 100 μM-Zn). Surface characterization was performed using scanning electron microscopy, X-ray photoelectron spectroscopy, X-ray diffraction, a three-dimensional profilometer, and a contact angle measuring device. The osteoblast-like cell line MC3T3-E1, Subclone 14, was used in cell viability assays to evaluate adhesion, proliferation, and ALP activity. An antibacterial assay was conducted using Streptococcus sanguinis and Fusobacterium nucleatum. Zn-incorporated samples exhibited higher adhesion, proliferation, and differentiation than did SLM and MAO samples. 100 μM Zn samples exhibited the highest proliferation, and 1 mM-Zn samples manifested the highest ALP activity. In addition, Zn-incorporated samples exerted inhibitory effects on both Streptococcus sanguinis and Fusobacterium nucleatum. Combining micro-arc oxidation and hydrothermal treatment, we successfully fabricated a novel Zn-incorporated coating on a microporous SLM surface which possesses both outstanding bioactivity and antibacterial efficacy.

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Section: Discussionmentioning

confidence: 99%

Enhanced Biocompatibility and Antibacterial Activity of Selective Laser Melting Titanium with Zinc-Doped Micro-Nano Topography

et al. 2019

Journal of Nanomaterials

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“…Titanium‐based alloys with strontium incorporated on their surface yielded similar results. [ 16,131,132 ] The studies reported improved adhesive, migration, and tube formation properties in vitro, suggesting likely enhanced vessel formation in vivo.…”

Section: Interaction Of Endothelial Cells With Inorganic Angiogenic Agentsmentioning

confidence: 99%

Inorganic Agents for Enhanced Angiogenesis of Orthopedic Biomaterials

Šalandová

Hengel

Apachitei

et al. 2021

Adv Healthcare Materials

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Aseptic loosening of a permanent prosthesis remains one of the most common reasons for bone implant failure. To improve the fixation between implant and bone tissue as well as enhance blood vessel formation, bioactive agents are incorporated into the surface of the biomaterial. This study reviews and compares five bioactive elements (copper, magnesium, silicon, strontium, and zinc) with respect to their effect on the angiogenic behavior of endothelial cells (ECs) when incorporated on the surface of biomaterials. Moreover, it provides an overview of the state-of-the-art methodologies used for the in vitro assessment of the angiogenic properties of these elements. Two databases are searched using keywords containing ECs and copper, magnesium, silicon, strontium, and zinc. After applying the defined inclusion and exclusion criteria, 59 articles are retained for the final assessment. An overview of the angiogenic properties of five bioactive elements and the methods used for assessment of their in vitro angiogenic potential is presented. The findings show that silicon and strontium can effectively enhance osseointegration through the simultaneous promotion of both angiogenesis and osteogenesis. Therefore, their integration onto the surface of biomaterials can ultimately decrease the incidence of implant failure due to aseptic loosening.

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“…To develop such a functional implant, surface modification is an effective approach. Recently, much research efforts on Ti surface modification, such as topographical modification and immobilization of bioactive molecules, have been carried out to enhance the osseointegration and antibacterial properties of the Ti materials . In general, Ti based implant materials with nanorod topologic structure exhibit inherent surface advantages thanks to their high surface area, controllable dimensions, and universal drug delivery capacity .…”

Section: Introductionmentioning

confidence: 99%

Fabrication of Chitosan‐18β‐Glycyrrhetinic Acid Modified Titanium Implants with Nanorod Arrays for Suppression of Osteosarcoma Growth and Improvement of Osteoblasts Activity

Zhang

Cheng

Gong

et al. 2017

Adv Funct Materials

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Surgery has been combined with chemotherapy to treat osteosarcoma. However, the recovery rate of osteosarcoma patients is still low. To prevent post-operative recurrence of the osteosarcoma, developing an alternative biomaterial is essential. 18β-Glycyrrhetinic acid (GA) has shown potential anticancer activity in various malignancies. Here it is proposed that GA can induce osteosarcoma cell apoptosis, and a polydopamine-mediated titanium oxide nanorod (TiO 2 NR) surface is functionalized by covalently grafting the chitosan-18β-glycyrrhetinic acid conjugate (CS-GA). In vitro and in vivo biological tests indicate that the CS-GA modified surface shows significant antiproliferation and apoptosis in osteosarcoma cells (MG63). Additionally, this modified surface with nanoarray structure stimulation and chitosan supplementation significantly promotes osteoblast (MC3T3-E1) adhesion and proliferation in vitro. This dual-functional, Ti-based implant with balanced antitumor and biocompatibility properties represents an effective strategy for the surgical treatment of osteosarcoma.

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Osteogenic activity and angiogenesis of a SrTiO₃ nano-gridding structure on titanium surface

Abstract: Dual effect of alveolate double-layered SrTiO3 nano-gridding based on Ti substrate: osteogenic activity and angiogenesis.

Cited by 26 publications

References 64 publications

Enhanced Biocompatibility and Antibacterial Activity of Selective Laser Melting Titanium with Zinc-Doped Micro-Nano Topography

Enhanced Biocompatibility and Antibacterial Activity of Selective Laser Melting Titanium with Zinc-Doped Micro-Nano Topography

Inorganic Agents for Enhanced Angiogenesis of Orthopedic Biomaterials

Fabrication of Chitosan‐18β‐Glycyrrhetinic Acid Modified Titanium Implants with Nanorod Arrays for Suppression of Osteosarcoma Growth and Improvement of Osteoblasts Activity

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Osteogenic activity and angiogenesis of a SrTiO3 nano-gridding structure on titanium surface

Abstract: Dual effect of alveolate double-layered SrTiO3 nano-gridding based on Ti substrate: osteogenic activity and angiogenesis.

Cited by 26 publications

References 64 publications

Enhanced Biocompatibility and Antibacterial Activity of Selective Laser Melting Titanium with Zinc-Doped Micro-Nano Topography

Enhanced Biocompatibility and Antibacterial Activity of Selective Laser Melting Titanium with Zinc-Doped Micro-Nano Topography

Inorganic Agents for Enhanced Angiogenesis of Orthopedic Biomaterials

Fabrication of Chitosan‐18β‐Glycyrrhetinic Acid Modified Titanium Implants with Nanorod Arrays for Suppression of Osteosarcoma Growth and Improvement of Osteoblasts Activity

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Osteogenic activity and angiogenesis of a SrTiO₃ nano-gridding structure on titanium surface