Osteoblast Activity on Anodized Titania Nanotubes: Effect of Simulated Body Fluid Soaking Time

Bayram, Cem; Demirbilek, Murat; Çalışkan, Nazlı; Demirbilek, Melike Erol; Denkbaş, Emir Baki

doi:10.1166/jbn.2012.1391

Cited by 31 publications

(24 citation statements)

References 46 publications

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“…The best biological answer was visible for nanotubes obtained at 5 V, whose diameters were ~20 nm [136]. This result is in accordance with earlier reports [127][128][129][130][131][132][133][134], however, our investigations revealed that the annealing of amorphous samples was not so indispensable [136].…”

Section: Titania Nanotubes (Tnts)supporting

confidence: 92%

“…Diameters of 15-20 nm are optimal and in case of such TNT presence on the surface of titanium implants, increase in adhesion and proliferation of several types of living cells, such as fibroblasts, osteoblasts, osteoclasts, mesenchymal stem cells, hematopoietic stem cells, and endothelial cells, was confirmed [127][128][129][130][131][132][133][134]. Higher tube diameters (>100 nm) have no positive influence on the increasing of adhesion or proliferation and some authors have shown that TNT of such diameters led to apoptosis, i.e., programmed cell death [135].…”

Section: Titania Nanotubes (Tnts)mentioning

confidence: 86%

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1D Titania Nanoarchitecture as Bioactive and Photoactive Coatings for Modern Implants: A Review

Radtke¹

2017

Application of Titanium Dioxide

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The research efforts in understanding the influence of TiO 2 1D nanoarchitecture structure and morphology on its biological and photocatalytic activity absorbed a lot of attention during last few years. Nowadays, the application of TiO 2 coatings in biomedical technologies (e.g., in modern implantology) requires the material of strictly defined structure and morphology, possessing both high biocompatibility, as well as antimicrobial properties. The presented review is a compilation of interdisciplinary knowledge about the application of 1D TiO 2 nanostructural coatings (nanotubes, nanofibres, nanowires) in biomedical technologies. The methods and parameters of their synthesis, and the physicochemical techniques used in the characterization of their structure and morphology, are discussed. Moreover, their ability to be applied as innovative coatings for modern implants is presented.

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Section: Titania Nanotubes (Tnts)supporting

confidence: 92%

Section: Titania Nanotubes (Tnts)mentioning

confidence: 86%

1D Titania Nanoarchitecture as Bioactive and Photoactive Coatings for Modern Implants: A Review

Radtke¹

2017

Application of Titanium Dioxide

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“…41 Previous studies showed that surface wettability and roughness were crucially important for cellular responses to the substrates. [42][43][44] In the present study, we show that the water contact angle was signicantly decreased by the HA coating on the Ti 6 Al 4 V scaffold ( Fig. 1C(d)), indicating that the surface wettability and hydrophilicity was substantially enhanced.…”

Section: Discussionsupporting

confidence: 55%

Bone regeneration in critically sized rat mandible defects through the endochondral pathway using hydroxyapatite-coated 3D-printed Ti₆Al₄V scaffolds

et al. 2018

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“…After etching, plates were washed with deionized water and air-dried at 70°C inside a vacuum oven. 44…”

Section: Titanium Platesmentioning

confidence: 99%

Dual delivery of platelet‐derived growth factor and bone morphogenetic factor‐6 on titanium surface to enhance the early period of implant osseointegration

Keçeli

Bayram

Çelik

et al. 2020

J of Periodontal Research

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Objective To test the surface properties and in vitro effects of a new sequential release system on MC3T3‐E1 cells for improved osseointegration. Background BMP6‐loaded anodized titanium coated with PDGF containing silk fibroin (SF) may improve osseointegration. Methods Titanium surfaces were electrochemically anodized, and SF layer was covered via electrospinning. Five experimental groups (unanodized Ti (Ti), anodized Ti (AnTi), anodized + BMP6‐loaded Ti (AnTi‐BMP6), anodized + BMP6 loaded + silk fibroin‐coated Ti (AnTi‐BMP6‐SF), and anodized + BMP6‐loaded + silk fibroin with PDGF‐coated Ti (AnTi‐BMP6‐PDGF‐SF)) were tested. After SEM characterization, contact angle analysis, and FTIR analysis, the amount of released PDGF and BMP6 was detected using ELISA. Cell proliferation (XTT), mineralization, and gene expression (RUNX2 and ALPL) were also evaluated. Results After successful anodization and loading of PDGF and BMP6, contact angle measurements showed hydrophobicity for TiO2 and hydrophilicity for protein‐adsorbed surfaces. In FTIR, protein‐containing surfaces exhibited amide‐I, amide‐II, and amide‐III bands at 1600 cm‐1‐1700 cm‐1, 1520 cm‐1‐1540 cm‐1, and 1220 cm‐1‐1300 cm‐1 spectrum levels with a significant peak in BMP6‐ and/or SF‐loaded groups at 1100 cm‐1. PDGF release and BMP6 release were delayed, and relatively slower release was detected in SF‐coated surfaces. Higher MC3T3‐E1 proliferation and mineralization and lower gene expression of RUNX2 and ALPL were detected in AnTi‐BMP6‐PDGF‐SF toward day 28. Conclusion The new system revealed a high potential for an improved early osseointegration period by means of a better factor release curve and contribution to the osteoblastic cell proliferation, mineralization, and associated gene expression.

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Osteoblast Activity on Anodized Titania Nanotubes: Effect of Simulated Body Fluid Soaking Time

Cited by 31 publications

References 46 publications

1D Titania Nanoarchitecture as Bioactive and Photoactive Coatings for Modern Implants: A Review

1D Titania Nanoarchitecture as Bioactive and Photoactive Coatings for Modern Implants: A Review

Bone regeneration in critically sized rat mandible defects through the endochondral pathway using hydroxyapatite-coated 3D-printed Ti₆Al₄V scaffolds

Dual delivery of platelet‐derived growth factor and bone morphogenetic factor‐6 on titanium surface to enhance the early period of implant osseointegration

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Osteoblast Activity on Anodized Titania Nanotubes: Effect of Simulated Body Fluid Soaking Time

Cited by 31 publications

References 46 publications

1D Titania Nanoarchitecture as Bioactive and Photoactive Coatings for Modern Implants: A Review

1D Titania Nanoarchitecture as Bioactive and Photoactive Coatings for Modern Implants: A Review

Bone regeneration in critically sized rat mandible defects through the endochondral pathway using hydroxyapatite-coated 3D-printed Ti6Al4V scaffolds

Dual delivery of platelet‐derived growth factor and bone morphogenetic factor‐6 on titanium surface to enhance the early period of implant osseointegration

Contact Info

Product

Resources

About

Bone regeneration in critically sized rat mandible defects through the endochondral pathway using hydroxyapatite-coated 3D-printed Ti₆Al₄V scaffolds