1D Titania Nanoarchitecture as Bioactive and Photoactive Coatings for Modern Implants: A Review

Radtke, Aleksandra

doi:10.5772/intechopen.69138

Cited by 3 publications

(5 citation statements)

References 185 publications

(207 reference statements)

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“…Titania based coatings were produced on the surface of Ti6Al4V substrates by electrochemical oxidation (TiO 2 nanotubes (TNT)) or by thermal oxidation (TiO 2 nanoneedles (TNN)) according to the early reported procedure [ 48 , 49 , 50 ]. The TNT layers were produced in the range 3–20 V and the time of anodization was 20 min.…”

Section: Resultsmentioning

confidence: 99%

“…Taking into account results of our earlier investigations of titania nanoneedles (TNN) and their relatively low biointegration activity, we have decided to exclude TNN/Ag from biological research [ 50 ]. Bioactivity studies of TNT/Ag nanocomposities have been carried out for systems containing dispersed Ag nanoparticles (TNT10/25-TNT20/25) and for the TNT layer coated by dense packed Ag nanoparticles (TNT3/25).…”

Section: Resultsmentioning

confidence: 99%

“…The thermal oxidation of Ti6Al4V was conducted according known procedure in a vacuum tube furnace at temperatures between 475 and 500 °C under a pressure of 1–1.5 hPa for oxidation time t = 2 h [ 49 , 50 ]. The oxidation process was carried out in the presence of argon (Argon Pre-Pure, purity: 99.998%, impurity: oxygen < 5 ppm, moisture < 5 ppm, total hydrocarbons < 2 ppm) using the following flow rate 30 cm 3 /min.…”

Section: Methodsmentioning

confidence: 99%

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Optimization of the Silver Nanoparticles PEALD Process on the Surface of 1-D Titania Coatings

et al. 2017

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Plasma enhanced atomic layer deposition (PEALD) of silver nanoparticles on the surface of 1-D titania coatings, such as nanotubes (TNT) and nanoneedles (TNN), has been carried out. The formation of TNT and TNN layers enriched with dispersed silver particles of strictly defined sizes and the estimation of their bioactivity was the aim of our investigations. The structure and the morphology of produced materials were determined using X-ray photoelectron spectroscopy (XPS) and scanning electron miscroscopy (SEM). Their bioactivity and potential usefulness in the modification of implants surface have been estimated on the basis of the fibroblasts adhesion and proliferation assays, and on the basis of the determination of their antibacterial activity. The cumulative silver release profiles have been checked with the use of inductively coupled plasma-mass spectrometry (ICPMS), in order to exclude potential cytotoxicity of silver decorated systems. Among the studied nanocomposite samples, TNT coatings, prepared at 3, 10, 12 V and enriched with silver nanoparticles produced during 25 cycles of PEALD, revealed suitable biointegration properties and may actively counteract the formation of bacterial biofilm.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Optimization of the Silver Nanoparticles PEALD Process on the Surface of 1-D Titania Coatings

et al. 2017

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“…Our previous research [20,21,[24][25][26][27][28][29][30][31] focused on the development of technology to produce the bioactive coatings on the surface of Ti6Al4V alloy substrates, i.e., widely used material in the construction of orthopedic implants. However, in order to implement the developed nanocoatings into implant fabrication, it is necessary to estimate their bioactivity in detail.…”

Section: Introductionmentioning

confidence: 99%

Comprehensive Evaluation of the Biological Properties of Surface-Modified Titanium Alloy Implants

Piszczek

Radtke

Ehlert

et al. 2020

JCM

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An increasing interest in the fabrication of implants made of titanium and its alloys results from their capacity to be integrated into the bone system. This integration is facilitated by different modifications of the implant surface. Here, we assessed the bioactivity of amorphous titania nanoporous and nanotubular coatings (TNTs), produced by electrochemical oxidation of Ti6Al4V orthopedic implants' surface. The chemical composition and microstructure of TNT layers was analyzed by X-ray photoelectron spectroscopy (XPS) and X-ray diffraction (XRD). To increase their antimicrobial activity, TNT coatings were enriched with silver nanoparticles (AgNPs) with the chemical vapor deposition (CVD) method and tested against various bacterial and fungal strains for their ability to form a biofilm. The biointegrity and anti-inflammatory properties of these layers were assessed with the use of fibroblast, osteoblast, and macrophage cell lines. To assess and exclude potential genotoxicity issues of the fabricated systems, a mutation reversal test was performed (Ames Assay MPF, OECD TG 471), showing that none of the TNT coatings released mutagenic substances in long-term incubation experiments. The thorough analysis performed in this study indicates that the TNT5 and TNT5/AgNPs coatings (TNT5-the layer obtained upon applying a 5 V potential) present the most suitable physicochemical and biological properties for their potential use in the fabrication of implants for orthopedics. For this reason, their mechanical properties were measured to obtain full system characteristics.

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“…Under the influence of H 2 O 2 , the production of titanium peroxide gel is expected on the sample surface [18,25,26]. As a result of immersion of titanium foil in H 2 O 2 solution, metallic titanium reacts with H 2 O 2 molecules to form Ti-OH groups on the surface of titanium [26,27,28]. It can be expected that the longer the process is carried out, the rougher the layer will become [26].…”

Section: Introductionmentioning

confidence: 99%

Titania Nanofiber Scaffolds with Enhanced Biointegration Activity—Preliminary In Vitro Studies

Ehlert

Roszek

Jędrzejewski

et al. 2019

IJMS

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The increasing need for novel bone replacement materials has been driving numerous studies on modifying their surface to stimulate osteogenic cells expansion and to accelerate bone tissue regeneration. The goal of the presented study was to optimize the production of titania-based bioactive materials with high porosity and defined nanostructure, which supports the cell viability and growth. We have chosen to our experiments TiO2 nanofibers, produced by chemical oxidation of Ti6Al4V alloy. Fibrous nanocoatings were characterized structurally (X-ray diffraction (XRD)) and morphologically (scanning electron microscopy (SEM)). The wettability of the coatings and their mechanical properties were also evaluated. We have investigated the direct influence of the modified titanium alloy surfaces on the survival and proliferation of mesenchymal stem cells derived from adipose tissue (ADSCs). In parallel, proliferation of bone tissue cells—human osteoblasts MG-63 and connective tissue cells - mouse fibroblasts L929, as well as cell viability in co-cultures (osteoblasts/ADSCs and fibroblasts/ADSCs has been studied. The results of our experiments proved that among all tested nanofibrous coatings, the amorphous titania-based ones were the most optimal scaffolds for the integration and proliferation of ADSCs, fibroblasts, and osteoblasts. Thus, we postulated these scaffolds to have the osteopromotional potential. However, from the co-culture experiments it can be concluded that ADSCs have the ability to functionalize the initially unfavorable surface, and make it suitable for more specialized and demanding cells.

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1D Titania Nanoarchitecture as Bioactive and Photoactive Coatings for Modern Implants: A Review

Cited by 3 publications

References 185 publications

Optimization of the Silver Nanoparticles PEALD Process on the Surface of 1-D Titania Coatings

Optimization of the Silver Nanoparticles PEALD Process on the Surface of 1-D Titania Coatings

Comprehensive Evaluation of the Biological Properties of Surface-Modified Titanium Alloy Implants

Titania Nanofiber Scaffolds with Enhanced Biointegration Activity—Preliminary In Vitro Studies

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