Osteo mineralization of fibrin-decorated graphene oxide

Deepachitra, R.; Chamundeeswari, M.; Kumar, B. Santhosh; Krithiga, Gunasekaran; Prabu, P.; Devi, Madhabi; Sastry, T. P.

doi:10.1016/j.carbon.2012.12.070

Cited by 34 publications

(21 citation statements)

References 36 publications

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“…In general, GFNs are good HA nucleators due to their high surface area, and the presence of biomolecules always increase the amount and rate of HA precipitation [20,21,38,40,42]. Liu et al [20,38] showed the formation of HA on reduced GO (rGO) modified with a layer of in situ polymerized dopamine ( polydopamine, PDA) after one week and gelatinmodified GO after two weeks of immersion in 1.5 Â SBF.…”

Section: Arg-carboxylated Graphene Oxide As a Strong Nucleator Of Hydmentioning

confidence: 99%

Hydroxyapatite formation on graphene oxide modified with amino acids: arginine versus glutamic acid

Tavafoghi¹,

Brodusch²,

Gauvin³

et al. 2016

J. R. Soc. Interface.

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Hydroxyapatite (HA, Ca 5 (PO 4 ) 3 OH) is the main inorganic component of hard tissues, such as bone and dentine. HA nucleation involves a set of negatively charged phosphorylated proteins known as non-collagenous proteins (NCPs). These proteins attract Ca 2þ and PO 4 32 ions and increase the local supersaturation to a level required for HA precipitation. Polar and charged amino acids (AAs) are highly expressed in NCPs, and seem to be responsible for the mineralizing effect of NCPs; however, the individual effect of these AAs on HA mineralization is still unclear. In this work, we investigate the effect of a negatively charged (Glu) and positively charged (Arg) AA bound to carboxylated graphene oxide (CGO) on HA mineralization in simulated body fluids (SBF).Our results show that Arg induces HA precipitation faster and in larger amounts than Glu. We attribute this to the higher stability of the complexes formed between Arg and Ca 2þ and PO 4 32 ions, and also to the fact that Arg exposes both carboxyl and amino groups on the surface. These can electrostatically attract both Ca 2þ and PO 4 32 ions, thus increasing local supersaturation more than Glu, which exposes carboxyl groups only.

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Section: Arg-carboxylated Graphene Oxide As a Strong Nucleator Of Hydmentioning

confidence: 99%

Hydroxyapatite formation on graphene oxide modified with amino acids: arginine versus glutamic acid

Tavafoghi¹,

Brodusch²,

Gauvin³

et al. 2016

J. R. Soc. Interface.

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show abstract

“…Therefore, Gel scaffolds, especially large porous Gel sponges, have been widely used in tissue engineering. However, the strength is often not enough to support the growth of new tissue, and the stability of Gel scaffolds is not desirable owing to their water solubility [4]. Gel hydrogels are also of potential ability to be cross-linked with different materials to enhance their mechanical properties, including chitosan [45], poly(vinyl) alcohol [43], poly(ethylene glycol) [9], and sodium alginate [51].…”

Section: Introductionmentioning

confidence: 99%

Material properties in unconfined compression of gelatin hydrogel for skin tissue engineering applications

Karimi¹,

Navidbakhsh²

2014

Biomedical Engineering / Biomedizinische Technik

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Gelatin (Gel) has been reported as a promising candidate in tissue engineering owing to its easy availability, biocompatibility, and biodegradability. Gel hydrogel is of potential to be cross-linked with different materials to enhance their biocompatibility for cell culture for tissue engineering applications. The mechanical properties of this versatile material, however, have not been thoroughly determined. In this study, the linear elastic (Young's modulus and maximum stress) and non-linear hyperelastic (hyperelastic coefficients) mechanical properties of prepared hydrogels at different contents of Gel (wt%) were measured, and its Young's modulus was compared with that of skin tissue. The prepared cylindrical Gel hydrogels were subjected to a series of unconfined compression tests. The hyperelastic strain energy density function was calibrated using the compressive experimental data. The potential ability of the Yeoh hyperelastic constitutive equation, which has been proposed as the best material model to represent the non-linear behavior of hydrogels, was verified using finite element (FE) simulations. The results revealed that the Young's modulus and maximum stress of hydrogels are increased by the addition of Gel. The highest Young's modulus (81 kPa) and maximum stress (24 kPa) were observed for hydrogels with 15 wt% Gel. Results also showed that the hydrogels with a relatively lower content (<7.5 wt%) of Gel have suitable Young's modulus compared with those with a higher content (>7.5 wt%) for skin tissue engineering. The Yeoh material model was closely fitted with the experimental data and could be used in further biomechanical simulations of the hydrogels. The experimental results were also compared well with those predicted by the FE models. The results of this study might have implications not only for the understanding of the mechanical properties of Gel hydrogel but also for the fabrication of polymeric substrate materials suitable for skin tissue engineering applications.

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“…7 However, due to the lack of mechanical strength, it cannot be used to support the growth of the new tissue. 17 PAA, which is a high molecular weight polymer of acrylic acid, enables to absorb many times of their weight in water and is the basis of a class of materials called superabsorbents. These polymers are used in many applications, including diapers and personal hygiene products, ion exchange resins, membranes for hemodialysis and ultrafiltration, and controlled release devices.…”

Section: Introductionmentioning

confidence: 99%

Influence of Poly(acrylic acid) on the Mechanical Properties of Composite Hydrogels

et al. 2014

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Gelatin (Gel) and poly(acrylic acid) (PAA) have so many applications in wound dressing, drug release, and tissue engineering on the basis of their easy availability, biocompatibility, and biodegradability. A composition of Gel/PAA hydrogel is widely used as a biological glue of soft tissues. However, the influence of PAA on the mechanical properties of this composite hydrogel so far has not been determined. In this study, gel hydrogels were prepared at various PAA content, i.e., 10, 20, and 30 wt%, using a thermal-initiated redox polymerization method. Afterward, as=prepared cylindrical hydrogel samples were subjected to a series of compressive loading to measure their linear elastic (elastic modulus, maximum stress and strain) and nonlinear hyperelastic (hyperelastic coefficients) mechanical properties. The potential ability of the Yeoh material model to closely address the nonlinear mechanical behavior of the hydrogel was verified using finite element (FE) modeling of the compression test. The results showed that the addition of PAA (>10 wt%) invokes a significant decrease in the Young's modulus and maximum stress of the hydrogels whereas (1 of 7)RESEARCH ARTICLE a significant increase in the maximum strain. The highest Young's modulus (25 MPa) and maximum stress (12 MPa) were observed in the hydrogels with PAA (10 wt%), whereas the highest maximum strain (43%) was detected in the Gel/PAA (30 wt%) samples. The experimental results were well compared to those anticipated by the Yeoh and FE models. The results suggested that an optimum addition of PAA not only could enhance the mechanical strength of the hydrogels but also provide a nonlinear behavior of composite hydrogels, which is suitable for soft tissue engineering. C 2014 Wiley Periodicals, Inc. Adv Polym Technol 2015, 34, 21487; View this article online at wileyonlinelibrary.com.

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Osteo mineralization of fibrin-decorated graphene oxide

Cited by 34 publications

References 36 publications

Hydroxyapatite formation on graphene oxide modified with amino acids: arginine versus glutamic acid

Hydroxyapatite formation on graphene oxide modified with amino acids: arginine versus glutamic acid

Material properties in unconfined compression of gelatin hydrogel for skin tissue engineering applications

Influence of Poly(acrylic acid) on the Mechanical Properties of Composite Hydrogels

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