Material properties in unconfined compression of gelatin hydrogel for skin tissue engineering applications

Karimi, Alireza; Navidbakhsh, Mahdi

doi:10.1515/bmt-2014-0028

Cited by 47 publications

(29 citation statements)

References 53 publications

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“…It is widely used in tissue engineering on the basis of its availability, biocompatibility, and biodegradability. 7,8 Gel can mimic extracellular matrix (ECM) if it is incorporated into a hydrogel. It is, hence, possible to make a composite hydrogel, which is desirable for tissue regeneration by promoting cell adhesion, migration, differentiation, and proliferation.…”

Section: Introductionmentioning

confidence: 99%

Influence of Poly(acrylic acid) on the Mechanical Properties of Composite Hydrogels

et al. 2014

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Gelatin (Gel) and poly(acrylic acid) (PAA) have so many applications in wound dressing, drug release, and tissue engineering on the basis of their easy availability, biocompatibility, and biodegradability. A composition of Gel/PAA hydrogel is widely used as a biological glue of soft tissues. However, the influence of PAA on the mechanical properties of this composite hydrogel so far has not been determined. In this study, gel hydrogels were prepared at various PAA content, i.e., 10, 20, and 30 wt%, using a thermal-initiated redox polymerization method. Afterward, as=prepared cylindrical hydrogel samples were subjected to a series of compressive loading to measure their linear elastic (elastic modulus, maximum stress and strain) and nonlinear hyperelastic (hyperelastic coefficients) mechanical properties. The potential ability of the Yeoh material model to closely address the nonlinear mechanical behavior of the hydrogel was verified using finite element (FE) modeling of the compression test. The results showed that the addition of PAA (>10 wt%) invokes a significant decrease in the Young's modulus and maximum stress of the hydrogels whereas (1 of 7)RESEARCH ARTICLE a significant increase in the maximum strain. The highest Young's modulus (25 MPa) and maximum stress (12 MPa) were observed in the hydrogels with PAA (10 wt%), whereas the highest maximum strain (43%) was detected in the Gel/PAA (30 wt%) samples. The experimental results were well compared to those anticipated by the Yeoh and FE models. The results suggested that an optimum addition of PAA not only could enhance the mechanical strength of the hydrogels but also provide a nonlinear behavior of composite hydrogels, which is suitable for soft tissue engineering. C 2014 Wiley Periodicals, Inc. Adv Polym Technol 2015, 34, 21487; View this article online at wileyonlinelibrary.com.

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Section: Introductionmentioning

confidence: 99%

Influence of Poly(acrylic acid) on the Mechanical Properties of Composite Hydrogels

et al. 2014

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“…The hydrogel systems both offer a similar range of elastic moduli, 10 to 100s KPa [35,36], 469 which is significantly lower than the required to match the material compliance of a natural 470 artery. Hence the hydrogel will not be required to play a role in the mechanical support and …”

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confidence: 99%

3D patterned substrates for bioartificial blood vessels – The effect of hydrogels on aligned cells on a biomaterial surface

et al. 2015

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Surface features control cellular orientation and subsequently influence their functionality, a useful effect for cellularized biomedical devices. Such devices also can benefit from protective and cell friendly hydrogel coatings. However, literature is lacking on the fate of cells that have endured hydrogel coating whilst orientated on a biomaterial surface. In particular, elucidation of the cells ability to remain adherent and orientated post hydrogel addition. Coating requires two procedures that may be deleterious to the orientated cells: the surface pretreatment for gel binding and the hydrogel crosslinking reaction. We compare transglutaminase gelatin crosslinking and UV initiated PEGDA crosslinking, coated onto smooth muscle cells orientated on patterned PCL surfaces. This original study will be of considerable use to the wider biomaterials community.

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“…Although an innovative depth dependent biphasic transversely isotropic model has been used in this study to address the mechanical properties of the AC, it is the author's belief that a more complicated and precise model can be presented using hyperelastic material models, such as Ogden, [27][28][29] Mooney-Rivlin, [30][31][32][33][34] Neo-Hookean, [35][36][37][38] and Yeoh. [39][40][41][42][43][44][45][46][47][48] IV.…”

Section: Resultsmentioning

confidence: 99%

Model for analyzing the mechanical behavior of articular cartilage under creep indentation test

Elhamian¹,

Karami²,

Alizadeh³

et al. 2014

Journal of Applied Physics

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General rightsCopyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.• Users may download and print one copy of any publication from the public portal for the purpose of private study or research.• You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal ? Take down policyIf you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. In this study, an innovative depth dependent biphasic transversely isotropic model (DBT) was proposed to study the mechanical behavior of Articular Cartilage (AC). To find a more precise model to address the mechanical behavior of AC, the vital role of collagen fibers in all zones of the AC has been taken into account and depth dependent elasticity mechanical properties of cartilage are calculated as a function of collagen fibers orientation and volume fraction. Material parameters of permeability function were calculated in such a way that the variations of indenter displacement with time predicted by Finite Element Method (FEM) simulation for creep indentation test of the AC sample based on DBT model. In addition, the test was simulated by an isotropic-biphasic model to compare the capabilities of these two models and difference in mechanical behaviors of biphasic-isotropic and depth dependent transversely isotropic materials. According to the calculations, the presence of collagen fibers triggers increasing of stresses in fibers direction and decreasing of stresses perpendicular to fiber direction in the superficial and deep zones of AC. The findings of this study may have implications not only for calculating stress distributions in AC components but also for developing progressive damage model of AC for predicting osteoarthritic cartilage behavior in different cartilage-related diseases. V C 2014 AIP Publishing LLC.

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Material properties in unconfined compression of gelatin hydrogel for skin tissue engineering applications

Cited by 47 publications

References 53 publications

Influence of Poly(acrylic acid) on the Mechanical Properties of Composite Hydrogels

Influence of Poly(acrylic acid) on the Mechanical Properties of Composite Hydrogels

3D patterned substrates for bioartificial blood vessels – The effect of hydrogels on aligned cells on a biomaterial surface

Model for analyzing the mechanical behavior of articular cartilage under creep indentation test

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