Osseous reactions to three hemostatic agents

Ibarrola, Jose L.; Bjorenson, Jean E.; Austin, B.P.; Gerstein, Harold

doi:10.1016/s0099-2399(85)80123-0

Cited by 73 publications

(62 citation statements)

References 10 publications

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“…16 The assessment of experimental osseous defect repair in rat tibia has demonstrated that distinct osseous reactions happen depending on the haemostatic agent used and if it was either removed or left in the surgical site. It has been shown that osteogenesis in the Gelfoam group occurs faster 11 when compared to that observed in the Control and Beriplast groups. The results of the present study showed that the use of Beriplast and Gelfoam in osseous defects favored blood clot organization as well as osseous repair, mainly in the initial 7-and 14-day postoperative periods, while in the subsequent periods osteogenesis was similar in the control and experimental groups.…”

Section: Discussionmentioning

confidence: 88%

“…The sequence of events in rat tibia osseous repair was similar to that observed by other authors. 8,10,11,14,21 Seven days after surgery, the control group featured an osseous defect with connective tissue surrounding small and sparse neoformed osseous trabeculae, and filled with signs of osteogenesis organization and initiation, which occurred increasingly up to the 45-day postoperative period, when the surgical site was found filled with compact osseous tissue.…”

Section: Discussionmentioning

confidence: 99%

“…8 A large number of studies have demonstrated that this material initially provokes an inflammatory response, though with no long-term side effects on osseous formation if completely removed. 9,11,14,21 Beriplast -a fibrin sealer compounded by fibrinogen, factor XIII and thrombin, all isolated from human plasma and lyophilized -has an effect based on the final stage of coagulation. 16,24 Its major components, human fibrinogen and thrombin, lead to the formation of a fibrin clot that is stable and insoluble in the presence of FXIII and calcium.…”

Section: Introductionmentioning

confidence: 99%

“…At times, the combination of suture and tissue sealers has demonstrated the best results. 19 Many studies carried out both in the periapical region 2,23,28,29 and in osseous tissue 1,[8][9][10][11]14,20 have demonstrated that if the haemostatic agents are inadvertently left in the surgical site they can induce an inflammatory process and affect tissue repair. 2,3,9,28 The objective of this study was to assess the effects of haemostatic agents on osseous repair in rat tibia, aiming to observe the presence of inflammatory cells and osseous tissue formation.…”

Section: Introductionmentioning

confidence: 99%

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Effects of fibrin sealer and resorbable gelatin on the repair of osseous defects in rat tibia

2007

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Efeitos de selante de fibrina e de gelatina absorvível no reparo de defeitos ósseos em tíbia de rato Abstract: Gelfoam  -a biologically resorbable gelatin sponge -has the function of restricting hemorrhage, providing platelet rupture, and supporting fibrin threads. Beriplast  -a fibrinogen-thrombin compound -is used to adhere tissues, to consolidate sutures and in hemostasis. The objective of this study was to perform a histological analysis of the effects of haemostatic agents on osseous repair. These materials were inserted into surgical sites in young rat right and left tibiae. After the observation periods of 7, 14, 30 and 45 days, according to the bioethic protocol, the animals were killed, the tibiae were removed and fixed in 10% formalin and decalcified in equal parts of formic acid and sodium citrate solutions. After routine processing, the specimens were embedded in paraffin for microtomy. Analysis of the results demonstrated that the haemostatic agents are effective in controlling hemorrhage; they stimulate osteogenesis, featuring a pattern of osseous tissue formation similar to the control pattern, although the amount of osseous trabeculae was superior, especially in the Gelfoam group in the periods of 7 and 14 days; 30 days after surgery, the delay in tissue healing in the control group in relation to the experimental groups started to decrease, and the control and experimental groups exhibited similar tissue repair after 45 days, when all the groups exhibited secondary osseous tissue. Descriptors: Fibrin foam; Fibrin tissue adhesive; Osteogenesis; Rats; Tibia. Resumo: Gelfoam -uma esponja de gelatina biologicamente reabsorvível -tem por função coibir as hemorragias, promover o rompimento de plaquetas e sustentar a rede de fibrina. Beriplast P  -um composto de fibrinogênio-trombina -é usado na adesão de tecidos, consolidação de suturas e hemostasia. O objetivo deste estudo foi verificar histologicamente os efeitos de agentes hemostáticos na reparação óssea, os quais foram colocados em lojas cirúrgicas nas tíbias direita e esquerda de ratos jovens. Após os perío-dos de observação de 7, 14, 30 e 45 dias, segundo o protocolo bioético, os animais foram sacrificados, as tíbias foram removidas e fixadas em formalina a 10% e descalcificadas em partes iguais de soluções de ácido fórmico e citrato de sódio, para inclusão em parafina e microtomia. A análise dos resultados demonstrou que os agentes hemostáticos têm eficá-cia no controle hemorrágico; eles estimulam a osteogênese, provocando um padrão de formação de tecido ósseo semelhante ao padrão do grupo controle, embora a quantidade de trabéculas ósseas tenha sido superior principalmente no grupo do Gelfoam, nos períodos de 7 e 14 dias; após os 30 dias da cirurgia, o retardo na reparação tecidual do grupo controle em relação aos grupos experimentais começou a decrescer, tornando-se a reparação tecidual daquele semelhante à destes aos 45 dias, quando todos os grupos apresentaram tecido ósseo secundário.

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Section: Discussionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effects of fibrin sealer and resorbable gelatin on the repair of osseous defects in rat tibia

2007

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“…Cellulose reduced bone repair and caused inflammation. Gelatin was completely resorbed and healing was complete at 120 days [20]. MFC did not impair bone formation in rat tibias in the Haasch study of 1989 [16].…”

Section: Animal Studiesmentioning

confidence: 83%

The use of local agents: bone wax, gelatin, collagen, oxidized cellulose

Schonauer¹,

Tessitore²,

Moraci³

et al.

Haemostasis in Spine Surgery

137

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Polyethylene glycol/microfibrillar collagen composite as a new resorbable hemostatic bone wax

Orgill

Ehret

Regan

et al. 1998

J. Biomed. Mater. Res.

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Although bone wax is effective at achieving hemostasis, it is nonresorbable, causes a foreign body reaction, and inhibits osteogenesis. We report development of a polyethylene glycol/microfibrillar collagen composite (PEG/MFC) that has inherent hemostatic qualities, is biodegradable, and is compatible with bone repair. PEG/MFC composite (n = 42) was placed in 5 mm cranial defects in New Zealand white rabbits. Hemostasis and healing were compared to unfilled defects (n = 32) and defects filled with standard bone wax (n = 10). Both PEG/MFC and bone wax handled well and stopped bleeding. The polyethylene glycol component was resorbed by 8 h, and the microfibrillar collagen was resorbed over 2 months, eliciting only a minor inflammatory response during the first month. Defects filled with the PEG/MFC composite showed similar amounts of bony regeneration as did unfilled control defects. At 4 weeks, healing bone accounted for 43 +/- 13% in those treated with PEG/MFC and 47 +/- 19% defect area in untreated holes. In contrast, less than 1% of the area was bone in defects filled with bone wax (p < 0.05). PEG/MFC composite provided excellent bony hemostasis and did not inhibit bone growth.

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Osseous reactions to three hemostatic agents

Cited by 73 publications

References 10 publications

Effects of fibrin sealer and resorbable gelatin on the repair of osseous defects in rat tibia

Effects of fibrin sealer and resorbable gelatin on the repair of osseous defects in rat tibia

The use of local agents: bone wax, gelatin, collagen, oxidized cellulose

Polyethylene glycol/microfibrillar collagen composite as a new resorbable hemostatic bone wax

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