The use of local agents: bone wax, gelatin, collagen, oxidized cellulose

Schonauer, Claudio; Tessitore, Enrico; Moraci, A; Barbagallo, Giuseppe; Albanese, Vincenzo

doi:10.1007/3-540-27394-8_15

Cited by 81 publications

(146 citation statements)

References 38 publications

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“…Inspite of the development of newer materials for hemostasis, the more commonly used materials like oxidized cellulose have not changed in last 50 years. Furthermore, the use of hemostatic agents is not free from health risks and complications can arise as a result of physical attributes of the hemostatic material like mechanical compression or due to phlogistic effects secondary to their chemical nature [5,[9][10][11]. Oxidized cellulose is obtained by dissolving alpha cellulose in an alkaline organic solvent [4].…”

Section: Discussionmentioning

confidence: 99%

Acute-onset Paraplegia in Post-operative D3-D5 Meningioma Excision due to Intraspinal Oxidized Cellulose

Kukreja¹,

Telang²

2017

JCR

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Background: Intra-spinal oxidized cellulose-induced post-operative paraplegia has been a rare but devastating complication and has been variedly reported. This is one of the common hemostatic agent used and invariably left in-situ. However, oxidized cellulose is associated with the peculiar chemical property to swell and cause pocket-compression, especially in confined areas, which may recover but can also cause an everlasting complete/ partial neurological deficit. Case Report: Our patient, a 68 year old female operated for a D3-D5 level meningioma developed post-surgical acute-onset paraplegia. An immediate post-operative MRI, urgent re-exploration and meticulous decompression resulted in complete neurological recovery at six months post-operatively. Conclusion: We, thus, present this unusual but well-documented oxidized cellulose related complication and make an attempt to highlight and suggest some basic teaching points.

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Section: Discussionmentioning

confidence: 99%

Acute-onset Paraplegia in Post-operative D3-D5 Meningioma Excision due to Intraspinal Oxidized Cellulose

Kukreja¹,

Telang²

2017

JCR

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“…It generates an artificial clot lowering pH and causing a caustic effect (9). The clot is brownish because it has acid hematin (10).…”

Section: Discussionmentioning

confidence: 99%

Comparison of sternal intramedullary bleeding prevention strategies in cardiac surgery

Tavlasoglu¹,

Durukan²,

Kürklüoğlu³

et al. 2013

Turk J Med Sci

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A set of ester and amide derivatives of some acidic NSAIDs, including ibuprofen, ketoprofen, and mefenamic acid (1-3), were synthesized and evaluated for their in vivo analgesic and antiinflammatory activity using the p-benzoquinone-induced writhing test and the carrageenan-induced paw edema model, respectively. Among the synthesized compounds, ester derivatives of ketoprofen showed especially potent analgesic and antiinflammatory activity as compared to the parent drug. In vitro chemical stability studies revealed that ester and amide derivatives were chemically stable in simulated gastric (pH 1.2) and intestinal fluids (pH 6.8). In 80% human plasma, the ester derivatives were found to be relatively stable against plasma esterases over periods of 24 h, indicating that the observed activity was not due to the parent NSAIDs. Most of the compounds were found to be nonulcerogenic under the tested conditions.

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“…Hanyang Med Rev 2018 Mar;38(1): [3][4][5][6][7][8][9][10][11][12][13][14][15] have reciprocal action with other platelets and they undergo aggregation and adhesion process.…”

Section: Arteriolar Vasoconstrictionmentioning

confidence: 99%

“…Although the material has high cost-effectiveness, since it has to be applied precisely to the bone, its usage is restricted in a number of dermatologic surgery procedures. Side effects of bone wax use incorporate granuloma formation by foreign body reactions, local contagions, inhibition of tissue regeneration and bone healing, and embolization to distant sites including the pulmonary circulation [13][14][15].…”

Section: ) Temperature and Pressurementioning

confidence: 99%

“…Gelatin is relatively inexpensive, easy to handle and with thrombin application, its hemostatic ability may be boosted [13,28]. Gelfoam paste makes less contamination and relatively limited inhibition of bone restoration compared to bone wax, thus, it is a good substitute for suppression of bleeding from bony surfaces, like an incision wound at sternotomy [15].…”

Section: ) Gelatinmentioning

confidence: 99%

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