Osseointegration of titanium scaffolds manufactured by selective laser melting in rabbit femur defect model

Ilea, Aranka; Vrabie, Oana-Gabriela; Băbțan, Anida-Maria; Mitre, Viorel; Ruxanda, Flavia; Sárközi, Melinda; Barbu–Tudoran, Lucian; Mager, Voicu; Berce, Cristian; Boşca, Bianca Adina; Petrescu, Nausica Bianca; Cadar, Oana; Câmpian, Radu Septimiu; Barabáş, Réka

doi:10.1007/s10856-019-6227-9

Cited by 18 publications

(12 citation statements)

References 31 publications

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“…240,241 The preparation of Si-HAp coatings by low temperature methods and their in vivo evaluation have been carried out by several research groups. 242,243 For this aim Ti or Ti alloy macroporous scaffolds have been often chosen as substrates. Zhang et al 242 proposed Ti scaffolds prepared by fiber sintering coated with Si-HAp by a biomimetic method.…”

Section: In Vivo Studies Of Scaffolds Coated With Substituted-hapmentioning

confidence: 99%

Substituted hydroxyapatite coatings of bone implants

2020

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Section: In Vivo Studies Of Scaffolds Coated With Substituted-hapmentioning

confidence: 99%

Substituted hydroxyapatite coatings of bone implants

2020

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“…In [229], the preliminary in vitro studies presented good proliferation of osteoblast in scaffolds with pore size equal 350 µm. In [230], Ti scaffolds with meshes of 0.8 mm showed higher osseointegration compared with 1 mm mesh. When investigating the effect of porosity for titanium scaffolds [231], several viable cells for 60% and 73% porous titanium were more numerous than at 87% porous titanium.…”

Section: Osteoconductive and Osteoinductive Properties 721 In Vitrmentioning

confidence: 85%

Structural and Material Determinants Influencing the Behavior of Porous Ti and Its Alloys Made by Additive Manufacturing Techniques for Biomedical Applications

Dziaduszewska

Zieliński

2021

Materials

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One of the biggest challenges in tissue engineering is the manufacturing of porous structures that are customized in size and shape and that mimic natural bone structure. Additive manufacturing is known as a sufficient method to produce 3D porous structures used as bone substitutes in large segmental bone defects. The literature indicates that the mechanical and biological properties of scaffolds highly depend on geometrical features of structure (pore size, pore shape, porosity), surface morphology, and chemistry. The objective of this review is to present the latest advances and trends in the development of titanium scaffolds concerning the relationships between applied materials, manufacturing methods, and interior architecture determined by porosity, pore shape, and size, and the mechanical, biological, chemical, and physical properties. Such a review is assumed to show the real achievements and, on the other side, shortages in so far research.

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“…Therefore, materials fabricated by SLM had to be pre-treated with a bioactive substance to enhance the osteointegration [85,106]. We published two articles regarding Ti SLM in vitro and in vivo scaffolds' integration on oral cavity mesenchimal stem cells (apical papilla, interradicular bone, dental pulp) and rabbit model [107,108]. We used 600 µm pore size with 63.4% porosity and simple Ti scaffolds coated with HA.…”

Section: Discussionmentioning

confidence: 99%

Tissue Integration and Biological Cellular Response of SLM-Manufactured Titanium Scaffolds

Băbțan

Timuș

Şoriţău

et al. 2020

Metals

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Background: SLM (Selective Laser Melting)–manufactured Titanium (Ti) scaffolds have a significant value for bone reconstructions in the oral and maxillofacial surgery field. While their mechanical properties and biocompatibility have been analysed, there is still no adequate information regarding tissue integration. Therefore, the aim of this study is a comprehensive systematic assessment of the essential parameters (porosity, pore dimension, surface treatment, shape) required to provide the long-term performance of Ti SLM medical implants. Materials and methods: A systematic literature search was conducted via electronic databases PubMed, Medline and Cochrane, using a selection of relevant search MeSH terms. The literature review was conducted using the preferred reporting items for systematic reviews and meta-analysis (PRISMA). Results: Within the total of 11 in vitro design studies, 9 in vivo studies, and 4 that had both in vitro and in vivo designs, the results indicated that SLM-generated Ti scaffolds presented no cytotoxicity, their tissue integration being assured by pore dimensions of 400 to 600 µm, high porosity (75–88%), hydroxyapatite or SiO2–TiO2 coating, and bioactive treatment. The shape of the scaffold did not seem to have significant importance. Conclusions: The SLM technique used to fabricate the implants offers exceptional control over the structure of the base. It is anticipated that with this technique, and a better understanding of the physical interaction between the scaffold and bone tissue, porous bases can be tailored to optimize the graft’s integrative and mechanical properties in order to obtain structures able to sustain osseous tissue on Ti.

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Osseointegration of titanium scaffolds manufactured by selective laser melting in rabbit femur defect model

Cited by 18 publications

References 31 publications

Substituted hydroxyapatite coatings of bone implants

Substituted hydroxyapatite coatings of bone implants

Structural and Material Determinants Influencing the Behavior of Porous Ti and Its Alloys Made by Additive Manufacturing Techniques for Biomedical Applications

Tissue Integration and Biological Cellular Response of SLM-Manufactured Titanium Scaffolds

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