Osseointegration Improvement of Co-Cr-Mo Alloy Produced by Additive Manufacturing

Iatecola, Amilton; Longhitano, Guilherme Arthur; Antunes, Luiz Henrique Martinez; Jardini, André Luiz; Miguel, Emílio de Castro; Béreš, Miloslav; Lambert, Carlos Salles; Andrade, Tiago Neves; Buchaim, Rogério Leone; Buchaim, Daniela Vieira; Pomini, Karina Torres; Dias, Jefferson Aparecido; Spressão, Daniele Raineri Mesquita Serva; Félix, Marcílio; Cardoso, Guinéa Brasil Camargo; Cunha, Marcelo Rodrigues da

doi:10.3390/pharmaceutics13050724

Cited by 13 publications

(3 citation statements)

References 88 publications

(123 reference statements)

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“…e main causes of aseptic loosening are excessive wear and stress shielding of the prosthesis [19]. A large number of studies conducted by domestic and foreign materials and medical science and technology professionals to improve the antiwear and friction-reducing performance of artificial joint materials [20][21][22] show that there is no effective biological testing indicator yet for the phenomenon of osteolysis. For the control of osteolysis phenomenon, firstly, it is necessary to improve the material design and fixation technique of the prosthesis [7].…”

Section: Coated Titanium Alloy Co Cr Mo Alloymentioning

confidence: 99%

The Antibacterial Activity Comparison between Novel Carbon-Based Nanofilm Coated Titanium Alloy and Co-Cr-Mo Alloy

Ran

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Objective. The purpose of this study was to reveal the antibacterial activity of carbon-based nanofilm titanium alloy. Methods. The experiments were performed both in vitro and in vivo of animals using two circular-piece test specimens of the same specification, which were made from carbon-based nanofilm coated titanium alloy and commonly used in artificial joints Co-Cr-Mo alloy, respectively. In the in vitro experiments, the two test specimens were cocultured with standard strains of Staphylococcus aureus and Escherichia coli, and the antibacterial properties of the two test specimens were evaluated via inhibition zone size, scanning electron microscopy, fluorescence staining, colony forming unit count, and others; the cytotoxicities of the two test specimens were evaluated by coculturing and them with rabbit bone marrow mesenchymal stem cells (BMSCs). In the in vivo experiments, the two test specimens were implanted in the muscle tissue of experimental rabbits to evaluate their histocompatibilities. Results. Both in vitro cocultures of the carbon-based nanofilm titanium alloy and the Co-Cr-Mo alloy with Staphylococcus aureus and Escherichia coli failed to form inhibition zone. However, some biofilms were observed on the surface of the Co-Cr-Mo alloy. Fewer bacteria adhered to the carbon-based nanofilm titanium alloy can be observed via scanning electron microscopy and fluorescence staining techniques. Meanwhile, the colony forming counts showed that, compared with the Co-Cr-Mo alloy, the carbon-based nanofilm titanium alloy had fewer bacteria adhered ( P < 0.05 ). After coculture of the two test specimens with rabbit BMSCs, there was no significant difference in cell count, and both cell counts showed no cytotoxicity. In the in vivo experiment of animals, there are relatively fewer giant cells and better histocompatibility in tissues near the carbon-based nanofilm titanium alloy. Conclusion. Compared with Co-Cr-Mo alloy, the novel carbon-based nanofilm titanium alloy enjoys stronger in vitro antibacterial activity and better in vivo histocompatibility.

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Section: Coated Titanium Alloy Co Cr Mo Alloymentioning

confidence: 99%

The Antibacterial Activity Comparison between Novel Carbon-Based Nanofilm Coated Titanium Alloy and Co-Cr-Mo Alloy

Ran

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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“…Traditional fixation materials are generally nondegradable, including inert stainless steel (SS), titanium (Ti) and its alloys, and cobalt-chromium (Co-Cr) alloys [ 10 ]. They possess satisfactory biocompatibility, high wear resistance, and adequate mechanical strength ( Table 1 ) [ 11 , 12 , 13 ]. However, they have notable shortcomings when being applied in fracture fixation.…”

Section: Introductionmentioning

confidence: 99%

Zinc-Based Biodegradable Materials for Orthopaedic Internal Fixation

Liu

Qiao

et al. 2022

JFB

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Traditional inert materials used in internal fixation have caused many complications and generally require removal with secondary surgeries. Biodegradable materials, such as magnesium (Mg)-, iron (Fe)- and zinc (Zn)-based alloys, open up a new pathway to address those issues. During the last decades, Mg-based alloys have attracted much attention by researchers. However, the issues with an over-fast degradation rate and release of hydrogen still need to be overcome. Zn alloys have comparable mechanical properties with traditional metal materials, e.g., titanium (Ti), and have a moderate degradation rate, potentially serving as a good candidate for internal fixation materials, especially at load-bearing sites of the skeleton. Emerging Zn-based alloys and composites have been developed in recent years and in vitro and in vivo studies have been performed to explore their biodegradability, mechanical property, and biocompatibility in order to move towards the ultimate goal of clinical application in fracture fixation. This article seeks to offer a review of related research progress on Zn-based biodegradable materials, which may provide a useful reference for future studies on Zn-based biodegradable materials targeting applications in orthopedic internal fixation.

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“…There were no complications that needed to be reported and no diseases or signs recommending the removal of an animal (clinical outcome) were observed 40 . In addition, our research group has experience in the method used, as demonstrated by previously published studies 11,[41][42][43] .…”

mentioning

confidence: 99%

Collagen-chitosan-hydroxyapatite composite scaffolds for bone repair in ovariectomized rats

Chacon

Bertolo

Plepis

et al. 2023

Sci Rep

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Lesions with bone loss may require autologous grafts, which are considered the gold standard; however, natural or synthetic biomaterials are alternatives that can be used in clinical situations that require support for bone neoformation. Collagen and hydroxyapatite have been used for bone repair based on the concept of biomimetics, which can be combined with chitosan, forming a scaffold for cell adhesion and growth. However, osteoporosis caused by gonadal hormone deficiency can thus compromise the expected results of the osseointegration of scaffolds. The aim of this study was to investigate the osteoregenerative capacity of collagen (Co)/chitosan (Ch)/hydroxyapatite (Ha) scaffolds in rats with hormone deficiency caused by experimental bilateral ovariectomy. Forty-two rats were divided into non-ovariectomized (NO) and ovariectomized (O) groups, divided into three subgroups: control (empty defect) and two subgroups receiving collagen/chitosan/hydroxyapatite scaffolds prepared using different methods of hydroxyapatite incorporation, in situ (CoChHa1) and ex situ (CoChHa2). The defect areas were submitted to macroscopic, radiological, and histomorphometric analysis. No inflammatory processes were found in the tibial defect area that would indicate immune rejection of the scaffolds, thus confirming the biocompatibility of the biomaterials. Bone formation starting from the margins of the bone defect were observed in all rats, with a greater volume in the NO groups, particularly the group receiving CoChHa2. Less bone formation was found in the O subgroups when compared to the NO. In conclusion, collagen/chitosan/hydroxyapatite scaffolds stimulate bone growth in vivo but abnormal conditions of bone fragility caused by gonadal hormone deficiency may have delayed the bone repair process.

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Osseointegration Improvement of Co-Cr-Mo Alloy Produced by Additive Manufacturing

Cited by 13 publications

References 88 publications

The Antibacterial Activity Comparison between Novel Carbon-Based Nanofilm Coated Titanium Alloy and Co-Cr-Mo Alloy

The Antibacterial Activity Comparison between Novel Carbon-Based Nanofilm Coated Titanium Alloy and Co-Cr-Mo Alloy

Zinc-Based Biodegradable Materials for Orthopaedic Internal Fixation

Collagen-chitosan-hydroxyapatite composite scaffolds for bone repair in ovariectomized rats

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