Os leucócitos e a resposta inflamatória na lesão de isquemia-reperfusão

Francischetti, Ieda; Moreno, José Bitu; Scholz, Martin; Yoshida, Winston Bonetti

doi:10.1590/s0102-76382010000400023

Cited by 41 publications

(22 citation statements)

References 61 publications

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“…This leads to multi-system and multi-cell activation and produces a large number of humoral and cellular inflammatory mediators through a cascade reaction, which eventually causes tissue and organ damage or even multiple organ dysfunction syndrome [8-10]. Causes of SIRS also include surgical injury, anesthesia, changes in body temperature, organ ischemia/reperfusion injury, machine blood transfusion, hemodilution, and heparin-protamine complexes [11,12]. It is important to understand the claim of minimal invasion of totally thoracoscopic cardiac surgery apart from the size of the incision.…”

Section: Discussionmentioning

confidence: 99%

Totally thoracoscopic repair of atrial septal defect reduces systemic inflammatory reaction and myocardial damage in initial patients

Liu

Zhu

et al. 2014

Eur J Med Res

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BackgroundTo compare the effect of totally thoracoscopic with conventional, open repair of atrial septal defect.MethodsForty atrial septal defect cases were divided into two groups by surgical approach: totally thoracoscopic approach (group A, n = 20) and conventional open approach (group B, n = 20). In group A, surgical procedures were performed through three portal incisions in the right lateral chest wall under thoracoscopic vision without the aid of a computerized robotic surgical system. Notably, all operations were completed by one surgeon who had just begun using this technique. In group B, the atrial septal defects were repaired in conventional open fashion. Clinical outcomes and serum levels of tumor necrosis factor α (TNF-α), interleukin-6 (IL-6), interleukin-10 (IL-10), intercellular adhesion molecule 1 (ICAM-1), and creatine kinase isoenzyme-myocardial band (CK-MB) for the two groups were evaluated and compared.ResultsAll operations were performed successfully without serious complications. Durations of cardiopulmonary bypass (CPB), CPB setup, aortic cross-clamping, and operative procedure were significantly longer in group A than in group B (P < 0.05). The recovery times for body temperature and laboratory values of leukocytes were significantly shorter for group A than for group B (P < 0.05). There were no differences in durations of postoperative assisted ventilation or intensive care unit and hospital stays, volumes of blood transfused intraoperatively or thoracic drainage, or medical costs between the two groups. Serum levels of inflammatory factors (TNF-α, IL-6, IL-10, and ICAM-1) and CK-MB increased significantly in both groups after surgery. However, 6 h and 12 h after surgery, levels of these inflammatory factors and CK-MB were significantly lower in group A than in group B (P < 0.05).ConclusionsThoracoscopic cardiac surgery is technically feasible and safe, with less trauma and quicker recovery even when done by a surgeon newly introduced to the technique.

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Section: Discussionmentioning

confidence: 99%

Totally thoracoscopic repair of atrial septal defect reduces systemic inflammatory reaction and myocardial damage in initial patients

Liu

Zhu

et al. 2014

Eur J Med Res

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“…It is clear that protein exudation is more closely related to edema than to other events [33]. These chemical mediators released by the leucocytes and other recruited cells are responsible, for example, for the hypersensitization of nerve fibers, which cause inflammatory pain or hyperalgesia [34].…”

Section: Discussionmentioning

confidence: 99%

Analgesic, Anti-Inflammatory, and Antioxidant Activities of Byrsonima duckeana W. R. Anderson (Malpighiaceae)

Verdam

Guilhon-Simplicio

Andrade

et al. 2017

The Scientific World Journal

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Background. Byrsonima is a promising neotropical genus, rich in flavonoids and triterpenes, with several proven pharmacological properties. Nevertheless, Byrsonima duckeana W. R. Anderson is an Amazonian species almost not studied. Objective. To assess the antioxidant, anti-inflammatory, and analgesic activities of Byrsonima duckeana leaves. Materials and Methods. We analyzed an ethanol extract and its fractions for polyphenol content and UHPLC-MS/MS, phosphomolybdenum, DPPH, TBARS antioxidant tests, formalin-induced pain, carrageenan-induced peritonitis, acetic acid-induced abdominal writhings, and hot plate assays. Results. All the samples showed high polyphenol content and antioxidant capacity in the phosphomolybdenum, DPPH, and TBARS tests. We identified ethyl gallate, quinic acid, gallic acid, catechin, epicatechin, quercetrin, and quercetin in the samples. B. duckeana was able to reduce leukocyte migration in the carrageenan-induced peritonitis by 43% and the licking time in the formalin test by 57%. In the acetic acid-induced writhing test, the chloroform (FCL) and ethyl acetate (FEA) fractions were the most active samples. FEA was selected for the hot plate test, where all the dosages tested (5, 50, and 200 mg·kg−1) showed significant analgesic activity. Conclusion. B. duckeana has interesting analgesic and antioxidant activities, due to its high phenolic content, especially phenolic acids.

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“…The interaction between neutrophils and the endothelium depends on the action of some integrins and cell adhesion molecules such as ICAM-1 [8]. Chen et al [2] in 2004, demonstrated, through clinical study involving patients undergoing cardiac surgery with CPB, that the release of inflammatory substances during CPB corrupts the transendothelial migration of leukocytes and platelets, with subsequent disordered displacement of these cells to the tissues.…”

Section: Discussionmentioning

confidence: 99%

Revascularização miocárdica com circulação extracorpórea; aspectos bioquímicos, hormonais e celulares

Gabriel¹,

Locali²,

Matsuoka³

et al. 2011

Rev Bras Cir Cardiovasc

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Revascularização miocárdica com circulação extracorpórea; aspectos bioquímicos, hormonais e celularesOn-pump coronary artery bypass graft surgery: biochemical, hormonal and cellular features This study was carried out at Federal University of São Paulo, Discipline of Cardiovascular Surgery, São Paulo, SP, Brazil. Methods: Eighteen patients underwent on-pump CABG surgery. Mean time of CPB was 80.3 minutes. Hormonal, biochemical and cellular measurements were taken in some time points -preoperatively, immediately after coming off CPB, 24 and 48 hours postoperatively. Friedman and Wilcoxon tests were applied based on significance level of 5%.Results: There was activation and significant elevation of total leukocytes and neutrophils count over CPB, remaining this way up to 48 hours postoperatively. Total platelets count, in turn, was marked by relevant reduction immediately after coming off CPB as well as in two postoperative time points. Serum levels of total proteins and albumin, immediately after coming off CPB and also in two postoperative time points, were significantly decreased comparing with preoperative status. There was remarkable reduction of total T3, free T3 and total T4 particularly up to first 24 hours postoperatively.Conclusion: In on-pump CABG surgery, inflammatory effects encompass activation of total leukocytes, neutrophils and platelets, reduction of serum level of total proteins and albumin and decreased thyroid hormones levels, especially within first postoperative 24 hours.

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Os leucócitos e a resposta inflamatória na lesão de isquemia-reperfusão

Cited by 41 publications

References 61 publications

Totally thoracoscopic repair of atrial septal defect reduces systemic inflammatory reaction and myocardial damage in initial patients

Totally thoracoscopic repair of atrial septal defect reduces systemic inflammatory reaction and myocardial damage in initial patients

Analgesic, Anti-Inflammatory, and Antioxidant Activities of Byrsonima duckeana W. R. Anderson (Malpighiaceae)

Revascularização miocárdica com circulação extracorpórea; aspectos bioquímicos, hormonais e celulares

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