Analgesic, Anti-Inflammatory, and Antioxidant Activities of Byrsonima duckeana W. R. Anderson (Malpighiaceae)

Abstract

Background. Byrsonima is a promising neotropical genus, rich in flavonoids and triterpenes, with several proven pharmacological properties. Nevertheless, Byrsonima duckeana W. R. Anderson is an Amazonian species almost not studied. Objective. To assess the antioxidant, anti-inflammatory, and analgesic activities of Byrsonima duckeana leaves. Materials and Methods. We analyzed an ethanol extract and its fractions for polyphenol content and UHPLC-MS/MS, phosphomolybdenum, DPPH, TBARS antioxidant tests, formalin-induced pain, carrageenan-induced peritonitis, acetic acid-induced abdominal writhings, and hot plate assays. Results. All the samples showed high polyphenol content and antioxidant capacity in the phosphomolybdenum, DPPH, and TBARS tests. We identified ethyl gallate, quinic acid, gallic acid, catechin, epicatechin, quercetrin, and quercetin in the samples. B. duckeana was able to reduce leukocyte migration in the carrageenan-induced peritonitis by 43% and the licking time in the formalin test by 57%. In the acetic acid-induced writhing test, the chloroform (FCL) and ethyl acetate (FEA) fractions were the most active samples. FEA was selected for the hot plate test, where all the dosages tested (5, 50, and 200 mg·kg−1) showed significant analgesic activity. Conclusion. B. duckeana has interesting analgesic and antioxidant activities, due to its high phenolic content, especially phenolic acids.

UHPLC-(ESI)-HRMS and NMR-Based Metabolomics Approach to Access the Seasonality of Byrsonima intermedia and Serjania marginata From Brazilian Cerrado Flora Diversity

“…Some of these plant species include Byrsonima intermedia and Serjania marginata , which present similar ethnopharmacological characteristics and have been found to be promising for future application in phytotherapy aimed at the treatment of inflammatory diseases. The hydroethanolic extracts obtained from the leaves of each of these species demonstrated potential gastroprotective ( Arruda et al, 2009 ; Périco et al, 2015 ; dos Santos et al, 2019 ), anti-inflammatory ( Moreira et al, 2011 ; Salinas-Sánchez et al, 2017 ), antioxidant ( Heredia-Vieira et al, 2015 ; Guilhon-Simplicio et al, 2017 ), analgesic ( Di Stasi et al, 1988 ; Verdam et al, 2017 ) activities and absence of toxicity in the acute models evaluated ( Santos et al, 2012 ; Périco et al, 2015 ; dos Santos et al, 2019 ).…”

Deeper Insights on Alchornea cordifolia (Schumach. & Thonn.) Müll.Arg Extracts: Chemical Profiles, Biological Abilities, Network Analysis and Molecular Docking

“…Interestingly, gallic acid, ellagic acid, shikimic acid, vitexin, rutin, quercetin, myricetin, quercitrin, kaempferol, and naringenin were among the compounds commonly identified in all the studied extracts ( Table 2 ). Many of these polyphenolic compounds have been extensively documented to possess important biological activities such as antioxidant, anti-inflammatory, and anti-tumoral activities, as well as to exert beneficial effects on cardiovascular and brain functions, amongst other effects [ 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 ].…”

Anti-inflammatory and ulcerogenic activities of thiazolidine-4-ones in rats

“…22 Carrageenan induced paw edema model is widely used to investigate the pathophysiology of the inflammatory response and to characterize the novel anti-inflammatory drugs. 5,18,23,24 Carrageenan injection produces two inflammatory phases and a third, uncharacteristic phase.…”