Orofacial Analgesic-Like Activity of Carvacrol in Rodents

Guimarães, Adriana Gibara; Silva, Francilene V.; Xavier, Maria Aldenise; Santos, Márcio Roberto Viana dos; Oliveira, Rita C. M.; Oliveira, Makson Gleydson Brito de; Oliveira, Aldeídia Pereira de; Souza, Clisiane C. De; Quintans‐Júnior, Lucindo José

doi:10.1515/znc-2012-9-1006

Cited by 17 publications

(3 citation statements)

References 19 publications

(24 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Such outcomes suggest that carvacrol might interfere with the production of inflammatory mediators and hence improve the healing of ulcers. 53 , 54 As a result, OEO could be considered a good candidate for relieving the pain and inflammation associated with some oral and dental conditions. Similar results were reported in the literature for the ability of cinnamon oil-based NEs to exert good antifungal, antibacterial, and analgesic effects against oral microbiota.…”

Section: Resultsmentioning

confidence: 99%

Formulation, Optimization, and Evaluation of Oregano Oil Nanoemulsions for the Treatment of Infections Due to Oral Microbiota

Hosny¹,

Asfour²,

Rizg³

et al. 2021

IJN

View full text Add to dashboard Cite

Introduction Natural oil-based nanoemulsions (NEs) have been widely investigated in many diseases that affect the oral cavity. NEs are delivery systems that enhance the solubility of lipid therapeutics and improve their delivery to target sites; they are known as self-nanoemulsifying drug delivery systems (SNEDDSs). The current investigation’s aim was to produce an oregano essential oil-based nanoemulsion (OEO-SNEDD) that would have antibacterial and antifungal effects against oral microbiota and improve oral health. Methods Several OEO-SNEDDSs were developed using different percentages of OEO (10%, 14%, and 18%), percentages of a surfactant mixture Pluracare L64:Lauroglycol FCC (18%, 32%, and 36%), S mix ratios (1:2, 1:1, and 2:1), and hydrophilic-lipophilic balances (HLBs) of the surfactant mixture (8, 10, and 12) using the Box‒Behnken design. The optimized concentration of excipients was determined using a pseudoternary phase diagram to obtain the NEs. The formulations were evaluated for their droplet size, stability index, and antibacterial and antifungal activities. Results The NEs had a droplet size of 150 to 500 nm and stability index of 47% to 95%, and the produced formulation reached antibacterial and antifungal inhibition zones of up to 19 and 17 mm, respectively. The Box‒Behnken design was adopted to get the optimum formulation, which was 18% OEO, 36% S mix , 10.29 HLB of S mix , and a 1.25:1 S mix ratio. The optimized formulation had a lower ulcer index compared with various other formulations evaluated in rats. Conclusion This study illustrated that OEO-SNEDDSs can provide good protection against oral microbial infections.

show abstract

Section: Resultsmentioning

confidence: 99%

Formulation, Optimization, and Evaluation of Oregano Oil Nanoemulsions for the Treatment of Infections Due to Oral Microbiota

Hosny¹,

Asfour²,

Rizg³

et al. 2021

IJN

View full text Add to dashboard Cite

show abstract

“…While the standard had an IC50 value of 15.58 g/ml (Table 1 and 2). According to the literature, carvacrol inhibits inflammation generated by carrageenan and tumour necrosis factor-alpha in a mouse model (11) .Carvacrol has also been shown to have anti-inflammatory and antiulcer properties, according to Silva and colleagues. They believe that carvacrol inhibits inflammatory mediators and hence promotes recovery (5).…”

Section: Discussionmentioning

confidence: 99%

Anti-Inflammatory Potential of Intracanal Medicament Containing Oregano Essential Oil

et al. 2022

View full text Add to dashboard Cite

Oregano is widely used as aromatics in food and alcohol. Oregano oil has been used in traditional medicine for decades. Oregano essential oil (OEO) is extracted from leaves from the oregano plant. Oregano is known for its antibacterial and antispasmodic properties due to its polyphenol content, which includes many flavones. The aim of the study was to assess the Anti-Inflammatory Potential of Intracanal Medicament Containing Oregano Essential Oil (OEO). The anti-inflammatory activity of an intracanal medicament containing oregano essential oil at various concentrations was evaluated using the raw 264.7 cell line. The ability of extracts to suppress nitric oxide generation by cells was used to calculate percentage inhibition. Curcumin was used as the standard. The study concluded that anti-inflammatory activity of the formulation showed IC50 value of 94.34%, and hence can be used clinically to treat infected root canals.

show abstract

“…Natural plant products have been a significant source of new drugs for orofacial painful conditions [1,[14][15][16].…”

Section: Discussionmentioning

confidence: 99%

Orofacial antinociceptive effect of the ethanolic extract of Annona vepretorum Mart. (Annonaceae)

Silva

Macedo

Souza

et al. 2016

Zeitschrift Für Naturforschung C

Self Cite

View full text Add to dashboard Cite

Annona vepretorum Mart. (Annonaceae) is a species popularly known in Brazil as "araticum" and "pinha da Caatinga". We have evaluated the antinociceptive effects of A. vepretorum in formalin-, capsaicin-, and glutamate-induced orofacial nociception in mice. Male Swiss mice were pretreated with either saline (p.o.), A. vepretorum ethanol extract (Av-EtOH 25, 50 and 100 mg/kg, p.o.), or morphine (10 mg/kg, i.p.), before formalin, capsaicin, or glutamate was injected into the right upper lip. Pre-treatment with Av-EtOH at all doses produced a reduction in face-rubbing behavior induced by formalin in both phases, and these pre-treatments also produced a significant antinociceptive effect in the capsaicin and glutamate tests. Pre-treatment with naloxone (1.5 mg/kg, i.p.) did not reverse the antinociceptive activity of the extract at the dose of 100 mg/kg in the first phase of this test. Our results suggest that Av-EtOH might be useful in the treatment of orofacial pain.

show abstract

Orofacial Analgesic-Like Activity of Carvacrol in Rodents

Cited by 17 publications

References 19 publications

Formulation, Optimization, and Evaluation of Oregano Oil Nanoemulsions for the Treatment of Infections Due to Oral Microbiota

Formulation, Optimization, and Evaluation of Oregano Oil Nanoemulsions for the Treatment of Infections Due to Oral Microbiota

Anti-Inflammatory Potential of Intracanal Medicament Containing Oregano Essential Oil

Orofacial antinociceptive effect of the ethanolic extract of Annona vepretorum Mart. (Annonaceae)

Contact Info

Product

Resources

About