Original research Risk factors in Central Poland for the development of superficial and nodular basal cell carcinomas

Abstract

Introduction: In the last decades the number of skin carcinomas has dramatically increased, which is mainly connected with changes in lifestyle, especially with common use of artificial light sources such as sunbeds. Basal cell carcinoma (BCC) is the most common form of skin cancer in white populations. Basal cell carcinomas are divided into subtypes, depending on their clinical picture and histology. The main groups are nodular (nBCC) and superficial (sBCC) ones. The major recognized risk factors for basal cell carcinoma (BCC) are exposure to chronic and intermittent burning doses of sunlight. Other risk factors leading to the development of the nBCC and sBCC subtypes of BCC are not well established. Material and methods: An analysis of 123 patients with either nBCC or sBCC, living in Lodz, Poland, regarding various intrinsic and environmental parameters was undertaken following the histological diagnosis of BCC. Results: No statistical differences were observed between the BCC subtype and sex, age, hair colour, eye colour, smoking, family history of skin cancer, occupation, or past episodes of sunburn. While sBCCs tended to occur on unexposed body sites in phototype I/II subjects who mainly avoided direct sunlight, nBCCs tended to occur on sun-exposed body sites in phototype III subjects who were frequently in direct sunlight. Conclusions: Thus the development of particular BCC subtypes is partially dependent on phototype and personal sun behaviour.

Lipid and protein oxidation in female patients with chronic fatigue syndrome

“…HDL-C is the beneficial form of blood cholesterol which protects the artery wall from atherosclerosis [43]. Even in individuals whose LDL levels are low, HDL remains a strong independent predictor of coronary artery disease risk [44]. Besides preventing cholesterol accumulation in cells of the artery wall, HDL-C acts as an anti-inflammatory agent by degrading lipid oxidation products [43–47].…”

Skin cancer in the elderly – epidemiological, clinical and surgical treatment analysis of 254 patients

“…During the last decades an increase of cutaneous malignancies has been shown in various studies [5,6]. In the region of Northern Poland that tendency is also noted [4].…”

Discordant expression of desmoglein 2 and 3 at the mRNA and protein levels in nodular and superficial basal cell carcinoma revealed by immunohistochemistry and fluorescentin situhybridization

“…It is possible that differences in Dsg2/Dsg3 profiles in nBCC and sBCC may be due to a different origin of these subtypes. It has even been suggested that BCC should not be treated as a single condition . On the other hand, many BCCs show a mixed histological pattern .…”