Abstract:Exposure of guinea-pigs to a C02-enriched atmosphere (20% C02, 25% 02, 55% N2) for I to 5 h caused a marked, progressive increase of plasma dopamine f3-hydroxylase (DBH) activity which reached its peak after 2 h of CO2 exposure and then gradually decreased. The increase was abolished by mecamylamine administration before exposure to CO2. Plasma levels of noradrenaline (NA) also increased after CO2 exposure. 2 Guanethidine administration, before exposure to C02, abolished the increase of plasma NA but potentiat… Show more
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