Orientin Inhibits HMGB1-Induced Inflammatory Responses in HUVECs and in Murine Polymicrobial Sepsis

Yoo, Hayoung; Ku, Sae Kwang; Lee, Tae‐Ho; Bae, Jong Sup

doi:10.1007/s10753-014-9899-9

Cited by 46 publications

(26 citation statements)

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“…Several recent studies have demonstrated that orientin exerts a variety of pharmacological effects, including antioxidant, anti-inflammatory, and neuroprotective effects [24,25]. For example, orientin (20 mg/kg and 40 mg/kg, intragastric administration) has shown significant antioxidant properties in improving the neuronal ultrastructure in the hippocampus of D-galactose-aged mice [26].…”

Section: Introductionmentioning

confidence: 99%

Protective effect of the orientin on noise-induced cognitive impairments in mice

Wang

Feng

et al. 2016

Behavioural Brain Research

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There is increasing evidence that chronic noise stress impairs cognition and induces oxidative stress in the brain. Recently, orientin, a phenolic compound abundant in some fruits, millet, and herbs, has been shown to have antioxidant properties. This study investigated the potential effects of orientin against chronic noiseinduced cognitive decline and its underlying mechanisms. A moderate-intensity noise exposure model was used to investigate the effects of orientin on behavior and biochemical alterations in mice. After 3 weeks of the noise exposure, the mice were treated with orientin (20 mg/kg and 40 mg/kg, oral gavage) for 3 weeks. The chronic noise exposure impaired the learning and memory in mice in the Morris water maze and step-through tests. The noise exposure also decreased exploration and interest in a novel environment in the open field test. The administration of orientin significantly reversed noise-induced alterations in these behavior tests. Moreover, the orientin treatment significantly improved the noise-induced alteration of serum corticosterone and catecholamine levels and oxidative stress in the hippocampus and prefrontal cortex. Furthermore, the orientin treatment ameliorated the noise-induced decrease in brain-derived neurotrophic factor and synapseassociated proteins (synaptophysin and postsynaptic density protein 95) in the hippocampus and prefrontal cortex. Thus, orientin exerts protective effects on noise-induced cognitive decline in mice, specifically by improving central oxidative stress, neurotransmission, and increases synapse-associated proteins. Therefore, supplementation with orientin-enriched food or fruit could be beneficial as a preventive strategy for chronic noise-induced cognitive decline. Disciplines Medicine and Health Sciences Publication DetailsWang, S., Yu, Y., Feng, Y., Zou, F., Zhang, X., Huang, J., Zhang, Y., Zheng, X., Huang, X., Zhu, Y. & Liu, Y. (2016). Protective effect of the orientin on noise-induced cognitive impairments in mice. Behavioural Brain Research, 296 290-300.

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Section: Introductionmentioning

confidence: 99%

Protective effect of the orientin on noise-induced cognitive impairments in mice

Wang

Feng

et al. 2016

Behavioural Brain Research

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“…1) are compounds found in C. subternata, which is a plant traditionally used for the production of the South African herbal tea called honeybush, and recently as aqueous extracts for the food industry (Joubert et al 2011). Flavonoids such as saponarin (Seo et al 2014), orientin, isoorientin (Lee et al 2014a;Yoo et al 2014), vitexin (Borghi et al 2013), and isovitexin (Lin et al 2005) are structural analogues of VCN or SCL with significant antiinflammatory properties. Therefore, in this study, we examined the anti-inflammatory responses of VCN and SCL on the release of HMGB1 and HMGB1-mediated vascular barrier disruptive responses in vitro and in vivo.…”

Section: Resultsmentioning

confidence: 99%

Antiseptic effect of vicenin-2 and scolymoside from Cyclopia subternata (honeybush) in response to HMGB1 as a late sepsis mediator in vitro and in vivo

Lee

Yoon

Kim

et al. 2015

Can. J. Physiol. Pharmacol.

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Cyclopia subternata is a medicinal plant commonly used in traditional medicine to relieve pain. In this study, we investigated the antiseptic effects and underlying mechanisms of vicenin-2 and scolymoside, which are 2 active compounds from C. subternata that act against high mobility group box 1 (HMGB1)-mediated septic responses in human umbilical vein endothelial cells (HUVECs) and mice. The antiseptic activities of vicenin-2 and scolymoside were determined by measuring permeability, neutrophil adhesion and migration, and activation of proinflammatory proteins in HMGB1-activated HUVECs and mice. According to the results, vicenin-2 and scolymoside effectively inhibited lipopolysaccharide-induced release of HMGB1, and suppressed HMGB1-mediated septic responses such as hyperpermeability, the adhesion and migration of leukocytes, and the expression of cell adhesion molecules. In addition, vicenin-2 and scolymoside suppressed the production of tumor necrosis factor-α and interleukin 6, and activation of nuclear factor-κB and extracellular regulated kinases 1/2 by HMGB1. Collectively, these results indicate that vicenin-2 and scolymoside could be a potential therapeutic agents for the treatment of various severe vascular inflammatory diseases via inhibition of the HMGB1 signaling pathway.

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“…Due to its antioxidant activity, orientin protects human erythrocytes in vitro from oxidative damage by attenuating oxidative stress; it protects antioxidative enzyme activities and preserves the integrity of the erythrocyte structure [31]. In an in vitro and in vivo study, antiinflammatory properties have been measured [32]. Of particular note, in an in vivo mouse model, orientin exerts antidepressantlike effects on mice, specifically by improving oxidative stress, neurotransmission, and neuroplasticity [33].…”

Section: Discussionmentioning

confidence: 99%

Improvement of Stress Resistance and Quality of Life of Adults with Nervous Restlessness after Treatment with a Passion Flower Dry Extract

et al. 2017

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Background: The passion flower dried ethanolic extract investigated in this non-interventional study has well-documented calmative effects and good tolerability. We investigated the effects of this extract on the stress resistance (resilience) and quality of life (QoL) of patients suffering from nervous restlessness. The addiction potential of the drug and the course of symptoms were also evaluated. Methods: Adult patients aged ≤ 95 years with the diagnosis ‘nervous restlessness' were treated for 12 weeks with a dried ethanolic extract of passion flower (Passiflora incarnata L.). Standardized questionnaires were used to evaluate the resilience (RS-13), QoL (EQ-5D including EQ-VAS), and the addiction potential (BDEPQ). Results: After 12 weeks of treatment, significant (p < 0.001) improvements were measured in the patients' resilience (RS-13: from 52.1 to 67.7 points) and QoL (EQ-VAS: from 47.9 to 75.0 points). Also, the mean BDEPQ score was significantly (p < 0.001) reduced (from 23.0 to 19.3 points). The mean values of all accompanying symptoms (inner restlessness, sleep disturbance, exhaustion, fear, lack of concentration, transpiration, nausea, trembling, and palpitation) improved significantly (p < 0.001). Tolerability of treatment was rated as ‘very good' or ‘good' by the majority of the patients. Three cases of mild adverse events (tiredness) were reported. Conclusion: The passion flower extract investigated in the present study appears to be effective in improving resilience and QoL in patients suffering from nervous restlessness and is well tolerated.

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Orientin Inhibits HMGB1-Induced Inflammatory Responses in HUVECs and in Murine Polymicrobial Sepsis

Cited by 46 publications

References 50 publications

Protective effect of the orientin on noise-induced cognitive impairments in mice

Protective effect of the orientin on noise-induced cognitive impairments in mice

Antiseptic effect of vicenin-2 and scolymoside from Cyclopia subternata (honeybush) in response to HMGB1 as a late sepsis mediator in vitro and in vivo

Improvement of Stress Resistance and Quality of Life of Adults with Nervous Restlessness after Treatment with a Passion Flower Dry Extract

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