Organic oxidations promoted in vortex driven thin films under continuous flow

Abstract

aWith increasing concerns for the environmental impact of chemical manufacturing, reagents and processes that align with the principles of green chemistry are essential. The fundamental oxidation of organic substrates is no exception and in this report three distinct modes of green oxidation are demonstrated in a vortex fluidic device (VFD) under continuous flow: aerobic oxidation, oxidation using chlorine bleach, and oxidation using hydrogen peroxide. The VFD, which is a thin film microfluidic platform, revealed clear advantages in these oxidations in comparison to traditional batch reactor processing: Efficient mass transfer of gases in the dynamic thin film increased the rate of aerobic oxidations, and the intense micromixing allowed multi-phase oxidations to proceed efficiently, obviating the need for organic solvents and phase transfer catalysts. In addition, the rapid dissipation of heat in the VFD also improved the safety profile and stereoselectivity for exothermic oxidations.

Vortex fluidic mediated synthesis of polysulfone

“…For q at 30 and 90 the yields were also relatively high, at 58.3% and 58.1% respectively, but given the higher M w ($7100 g mol À1 ) and T g ($153 C) at q 45 , this angle was regarded as optimal for the synthesis of PSF in the VFD, and this is in agreement with the outcome of optimisation studies for a number of applications of the device. [10][11][12][13][14][15][16]23 Understanding the complex uid ow in general in the VFD is a challenge, and is a major focus of our current research. The synthesis of PSF in the VFD was then carried out at 160 C, with u 6000 rpm and q 45 for different processing times, entries T 20 -T 22 , Table S1.…”

Vortex Fluidic Mediated Synthesis of TiO2 Nanoparticle/MXene Composites

“…[32] This is a proven approach for then translating any reaction into a continuous flow process, which is the other mode of operation of the VFD, Figure 1. [33] The VFD is a versatile thin film device effective for a growing number of applications, including in situ decorating h-BN with magnetite nanoparticles, [34] fabricating carbon dots from multi-walled carbon nanotubes, [35] chemo selective hydrogenation using cellulose impregnated with Pd NPs lining the VFD tube, [36] organic synthesis, [37][38] probing the structure of self-organised systems, [39][40] exfoliation and scrolling of h-BN and graphite, [41][42][43] slicing CNTs, [44][45] to mention a few. [41,[46][47][48][49][50][51][52][53][54] The VFD typically houses a borosilicate glass tube (O.D.…”

Continuous Flow Copper Laser Ablation Synthesis of Copper(I and II) Oxide Nanoparticles in Water

“…Under the centrifugal force, the liquid whirls up and exits at the top of the tube, and this continuous flow mode of operation of the VFD offers scalability to the processing by simply extending the operating time. 22−24 Applications of the VFD also include enhancing enzymatic reactions, 19 controlling organic synthesis, 20,25 probing the structure of self-organized systems, 26 protein separation, 27 exfoliation of 2D graphite and boron nitride, 21 protein folding, 28 and more, 23,29−31 Figure 1. Herein, we have established that the VFD is selective in forming copper(I) oxide (Cu 2 O) NPs with an average particle size of 14 nm in diameter, as a one-step continuous flow process at ambient pressure, with the oval operation avoiding a purification step.…”