Organelle size scaling over embryonic development

Wesley, Chase C; Mishra, Sampada; Levy, Daniel L.

doi:10.1002/wdev.376

Cited by 16 publications

(15 citation statements)

References 344 publications

(379 reference statements)

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“…Current models propose that spindles scale by changing the length of microtubules via a limiting cellular component that regulates microtubule polymerization dynamics [10,11,17,21,22]. Consistent with this proposal, microtubule growth velocity correlates with spindle size in early C. elegans and sea urchin embryos [17], and increased activity of the microtubule polymerase XMAP215 is sufficient to change spindle length in vitro and in vivo [16,22].…”

Section: Introductionmentioning

confidence: 85%

Spindle Scaling Is Governed by Cell Boundary Regulation of Microtubule Nucleation

et al. 2020

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Section: Introductionmentioning

confidence: 85%

Spindle Scaling Is Governed by Cell Boundary Regulation of Microtubule Nucleation

et al. 2020

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“…In each species, the cells can alter the morphology of the organelle to adjust the function by reflecting on drastic changes in the surrounding environments. For instance, the size of organelles varies among species and is dynamically altered throughout the cell cycle, as well as during development and differentiation in individual species (Chang and Marshall, 2017;Wesley et al, 2020). Considering the diversity in organelle size, there is a general principle of a scaling relationship inside the cell between the size of an organelle and the cell.…”

Section: Introductionmentioning

confidence: 99%

Specialization of nuclear membrane in eukaryotes

Hara

2020

Journal of Cell Science

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The size of the intracellular structure that encloses genomic DNAknown as the nucleus in eukaryotes and nucleoid in prokaryotesis believed to scale according to cell size and genomic content inside them across the tree of life. However, an actual scaling relationship remains largely unexplored across eukaryotic species. Here, I collected a large dataset of nuclear and cell volumes in diverse species across different phyla, including some prokaryotes, from the published literature and assessed the scaling relationship. Although entire inter-species data showed that nuclear volume correlates with cell volume, the quantitative scaling property exhibited differences among prokaryotes, unicellular eukaryotes and multicellular eukaryotes. Additionally, the nuclear volume correlates with genomic content inside the nucleus of multicellular eukaryotes but not of prokaryotes and unicellular eukaryotes. In this Hypothesis, I, thus, propose that the basic concept of nuclear-size scaling is conserved across eukaryotes; however, structural and mechanical properties of nuclear membranes and chromatin can result in different scaling relationships of nuclear volume to cell volume and genomic content among species. In particular, eukaryote-specific properties of the nuclear membrane may contribute to the extreme flexibility of nuclear size with regard to DNA density inside the nucleus.

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“…In an early embryo, the significant reduction of cell volume at each division supported by a fast cell cycle is a characteristic shared by most species 90,91 . Thus, the initial zygote volume together with the control of symmetric vs asymmetric divisions defines a global cell size patterns (Fig.…”

Section: Cell Size Patterningmentioning

confidence: 99%

“…In early embryos, organelles scale to the rapidly changing cellular dimensions through mechanisms that are currently not perfectly understood 90,99 . The impact of a modification of the cytoplasmic volume has been revealed in particular through alteration of the size of the egg/zygote using specific genetic background 100 or mechanical manipulations 92,101 .…”

Section: Cell Size Patterningmentioning

confidence: 99%