Organ-on-a-chip microengineering for bio-mimicking disease models and revolutionizing drug discovery

Ahmed, Tanvir

doi:10.1016/j.biosx.2022.100194

Cited by 14 publications

(19 citation statements)

References 275 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Even though there have been a lot of studies on organ on chip platform published over the past 10 years, only rare biological data are now accessible to address this problem. These results primarily highlight the use of more than one type of cells cocultured, as a miniature for a particular human organ-tissue, simple functional assays and specific characterization of tissue-tissue/cell-cell communications ( Ahmed, 2022 ). These research assessed the current breakthroughs in organ on chip platform, recognized new limitations that must be conquered to reorganize organ on chip platform models into respectable human Pathophysiologically relevant models, and discussed potential avenues of research to pursue in this area in the future ( Costa et al, 2020 ; Ramadan and Zourob, 2020 ).…”

Section: Introductionmentioning

confidence: 95%

“…Similarly, surface tension and wettability can impact the adhesion and migration of cells within microfluidic devices, which is important for studying processes such as angiogenesis and tumor metastasis ( Tovar-Lopez et al, 2019 ; Kausar et al, 2021 ; Farooqi et al, 2022 ; Kausar et al, 2022 ). These parameters enable the selection of appropriate materials, cell types, and culture conditions to ensure optimal organ functionality and accurate disease modeling ( Ahmed et al, 2022a ; Ahmed, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Revolutionizing drug development: harnessing the potential of organ-on-chip technology for disease modeling and drug discovery

et al. 2023

View full text Add to dashboard Cite

The inefficiency of existing animal models to precisely predict human pharmacological effects is the root reason for drug development failure. Microphysiological system/organ-on-a-chip technology (organ-on-a-chip platform) is a microfluidic device cultured with human living cells under specific organ shear stress which can faithfully replicate human organ-body level pathophysiology. This emerging organ-on-chip platform can be a remarkable alternative for animal models with a broad range of purposes in drug testing and precision medicine. Here, we review the parameters employed in using organ on chip platform as a plot mimic diseases, genetic disorders, drug toxicity effects in different organs, biomarker identification, and drug discoveries. Additionally, we address the current challenges of the organ-on-chip platform that should be overcome to be accepted by drug regulatory agencies and pharmaceutical industries. Moreover, we highlight the future direction of the organ-on-chip platform parameters for enhancing and accelerating drug discoveries and personalized medicine.

show abstract

Section: Introductionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

Revolutionizing drug development: harnessing the potential of organ-on-chip technology for disease modeling and drug discovery

et al. 2023

View full text Add to dashboard Cite

show abstract

“…Reproducibility has been improved in new 3D cell culture models in addition to delivering more physiologically relevant surroundings and improved prediction capabilities [236]. The fields of microfluidics and cell biology have reached a tipping point with the emergence of "organs on a chip" technologies, which may simulate organ-level in vivo properties in a laboratory environment using a microfluidic substrate that is becoming increasingly popular [237,238]. These cutting-edge technologies may be used to build better in vitro models for cancer research, expediting the discovery of novel treatments and the transition from laboratory to clinical testing, according to our predictions [239].…”

Section: Tumor-microenvironment-on-a-chipmentioning

confidence: 99%

“…Organon-a-chip technology has made considerable advances in TME microengineering in recent years. Consequently, it is now possible to create pathophysiologically realistic human cancer models [204,238].…”

Section: Tumor-microenvironment-on-a-chipmentioning

confidence: 99%

Functional biomaterials for biomimetic 3D in vitro tumor microenvironment modeling

Ahmed

2023

In vitro models

Self Cite

View full text Add to dashboard Cite

The translational potential of promising anticancer medications and treatments may be enhanced by the creation of 3D in vitro models that can accurately reproduce native tumor microenvironments. Tumor microenvironments for cancer treatment and research can be built in vitro using biomaterials. Three-dimensional in vitro cancer models have provided new insights into the biology of cancer. Cancer researchers are creating artificial three-dimensional tumor models based on functional biomaterials that mimic the microenvironment of the real tumor. Our understanding of tumor stroma activity over the course of cancer has improved because of the use of scaffold and matrix-based three-dimensional systems intended for regenerative medicine. Scientists have created synthetic tumor models thanks to recent developments in materials engineering. These models enable researchers to investigate the biology of cancer and assess the therapeutic effectiveness of available medications. The emergence of biomaterial engineering technologies with the potential to hasten treatment outcomes is highlighted in this review, which also discusses the influence of creating in vitro biomimetic 3D tumor microenvironments utilizing functional biomaterials. Future cancer treatments will rely much more heavily on biomaterials engineering.

show abstract

“…LOC devices could also be used for tissue or organ research. These devices are usually called organ-on-chips [ 12 ] or organoids-on-chips (OOCs); as the name suggests, these are chips with an organ/organ tissue that is grown inside the chip and will later be used for various tests, such as tests on drugs [ 13 , 14 ], toxins [ 15 ], and others [ 16 ]. One example is a liver-on-chip device [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Combined Femtosecond Laser Glass Microprocessing for Liver-on-Chip Device Fabrication

Butkutė

Jurkšas²,

Baravykas³

et al. 2023

Materials

View full text Add to dashboard Cite

Nowadays, lab-on-chip (LOC) devices are attracting more and more attention since they show vast prospects for various biomedical applications. Usually, an LOC is a small device that serves a single laboratory function. LOCs show massive potential for organ-on-chip (OOC) device manufacturing since they could allow for research on the avoidance of various diseases or the avoidance of drug testing on animals or humans. However, this technology is still under development. The dominant technique for the fabrication of such devices is molding, which is very attractive and efficient for mass production, but has many drawbacks for prototyping. This article suggests a femtosecond laser microprocessing technique for the prototyping of an OOC-type device—a liver-on-chip. We demonstrate the production of liver-on-chip devices out of glass by using femtosecond laser-based selective laser etching (SLE) and laser welding techniques. The fabricated device was tested with HepG2(GS) liver cancer cells. During the test, HepG2(GS) cells proliferated in the chip, thus showing the potential of the suggested technique for further OOC development.

show abstract

Organ-on-a-chip microengineering for bio-mimicking disease models and revolutionizing drug discovery

Cited by 14 publications

References 275 publications

Revolutionizing drug development: harnessing the potential of organ-on-chip technology for disease modeling and drug discovery

Revolutionizing drug development: harnessing the potential of organ-on-chip technology for disease modeling and drug discovery

Functional biomaterials for biomimetic 3D in vitro tumor microenvironment modeling

Combined Femtosecond Laser Glass Microprocessing for Liver-on-Chip Device Fabrication

Contact Info

Product

Resources

About