Organ mercury levels in infants with omphaloceles treated with organic mercurial antiseptic.

Fagan, D. G.; Pritchard, Jacki; Clarkson, Thomas W.; Greenwood, Michael R.

doi:10.1136/adc.52.12.962

Cited by 62 publications

(18 citation statements)

References 10 publications

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“…Axton (54) (56) reported on an attempted suicide from drinking a solution of thimerosal, resulting in severe poisoning. Treatment of infants with omphaloceles resulted in high levels of mercury in autopsy tissues (57). Cases of human poisoning have also occurred from infusion of large volumes of plasma containing thimerosal as a preservative (58,59).…”

Section: History Of Human Exposurementioning

confidence: 99%

The three modern faces of mercury.

Clarkson

2002

Environ Health Perspect

880

546

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Section: History Of Human Exposurementioning

confidence: 99%

The three modern faces of mercury.

Clarkson

2002

Environ Health Perspect

880

546

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“…31 Very high exposures to thimerosalcontaining products-as components of intramuscular injections, used for painting omphaloceles, as a preservative in ␥-globulin administered at highdoses or for a long period of time, or as intentionally ingested-have resulted in toxicity, including acrodynia, chronic mercury toxicity, renal failure, and neuropathy. [32][33][34][35][36] In an assay of chronic effects in rats, ethylmercury exposure resulted in renal and neurotoxicity in mature rats similar to exposure to methylmercury. 37 Follow-up studies in infants on the neurodevelopmental toxicity of ethylmercury in vaccines were done by the Centers for Disease Control and Prevention (CDC) using data from the Vaccine Safety Datalink project.…”

Section: Toxicitymentioning

confidence: 99%

Technical Report: Mercury in the Environment: Implications for Pediatricians

Goldman¹,

Shannon²

2001

Pediatrics

221

119

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ABSTRACT. Mercury is a ubiquitous environmental toxin that causes a wide range of adverse health effects in humans. Three forms of mercury (elemental, inorganic, and organic) exist, and each has its own profile of toxicity. Exposure to mercury typically occurs by inhalation or ingestion. Readily absorbed after its inhalation, mercury can be an indoor air pollutant, for example, after spills of elemental mercury in the home; however, industry emissions with resulting ambient air pollution remain the most important source of inhaled mercury. Because fresh-water and ocean fish may contain large amounts of mercury, children and pregnant women can have significant exposure if they consume excessive amounts of fish. The developing fetus and young children are thought to be disproportionately affected by mercury exposure, because many aspects of development, particularly brain maturation, can be disturbed by the presence of mercury. Minimizing mercury exposure is, therefore, essential to optimal child health. This review provides pediatricians with current information on mercury, including environmental sources, toxicity, and treatment and prevention of mercury exposure.

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“…The risk of mercury poisoning with the use of mercurochrome has been emphasised (Fagan et al, 1977). We believe this can be overcome by using mercurochrome without the impurity of free mercury and by using it only for a short period.…”

Section: Discussionmentioning

confidence: 99%