Organ culture studies on adenoviruses isolated from Tenosynovitis in chickens

Georgiou, K.; Jones, R. C.; Guneratne, J.R.M.

doi:10.1080/03079458308436163

Cited by 4 publications

(1 citation statement)

References 12 publications

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“…Abdalla (1979) in a study of tendons of chickens between 8 and 40 weeks of age found changes in the direction of fibres, appearance of fibroblasts, and mineralisation between 8 and 12 weeks, but details of changes before this time do not seem to be documented. The susceptibility of tendon tissue to reoviruses from birds of different ages might be determined by tendon organ culture studies such as those described by Georgiou et al (1983) for adenoviruses isolated from tenosynovitis.…”

Section: Discussionmentioning

confidence: 99%

Reovirus‐induced tenosynovitis in chickens the influence of age at infection

Jones

Georgiou²

1984

Avian Pathology

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Groups of specific pathogen-free (SPF) light hybrid chickens were infected with an arthrotropic reovirus at 1 day old, or at 2, 4, 6 or 9 weeks of age. In each group, approximately 20 were infected orally and 6 via the footpad. For each age group clinical signs of tenosynovitis, gross and microscopic lesions in the legs, virus excretion in the faeces, virus persistence in the joints, and precipitin response to reovirus were observed over a period of 9 weeks post infection (p.i.). For both routes of infection an age-limited susceptibility was shown, the most serious effects, both in numbers of affected birds and severity of gross lesions including tendon rupture, being seen in the youngest group. Gross lesions were rarely seen after oral infection of 6- and 9-week-old chickens. Footpad inoculation of virus had a more severe effect overall, and extended the age susceptibility, mild leg swellings being seen in some birds infected at 6 and 9 weeks of age. After oral infection, higher virus titres in the faeces and a more prolonged persistence in the gut and hock joint were recorded in chicks infected at 1 day old compared with the other age groups. Also, compared with the older groups, a delayed precipitin response was found in those infected at 1 day old. Footpad inoculation provoked earlier virus replication in the gut and a more rapid precipitin response.

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Section: Discussionmentioning

confidence: 99%

Reovirus‐induced tenosynovitis in chickens the influence of age at infection

Jones

Georgiou²

1984

Avian Pathology

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Adenovirus Infections

2013

Diseases of Poultry

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Experimental infection of chickens with adenoviruses isolated from tenosynovitis

Jones

Georgiou

1984

Avian Pathology

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Two adenoviruses isolated as the only viruses from the hock joints of chickens in outbreaks of tenosynovitis were tested for their ability to cause experimental tenosynovitis in chickens. It was previously shown that they were capable of growth in tendon organ cultures. One strain, designated 92, was used for infection of specific pathogen-free light hybrid chicks either in ovo at 17 days incubation or at 1-day-old orally or via the footpad. It was also used for infection of commercial broiler chicks at 1-day-old via the oral or footpad routes. The other virus, strain PS, was similarly used for infection of broiler chicks via the same routes. In none of the experiments did clinical signs or lesions of tenosynovitis develop other than transient inflammatory changes in the tissues and there was no evidence of prolonged virus persistence in hock joints. Of the tissues examined for virus, persistence was greatest in the gut.

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Organ culture studies on adenoviruses isolated from Tenosynovitis in chickens

Cited by 4 publications

References 12 publications

Reovirus‐induced tenosynovitis in chickens the influence of age at infection

Reovirus‐induced tenosynovitis in chickens the influence of age at infection

Adenovirus Infections

Experimental infection of chickens with adenoviruses isolated from tenosynovitis

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