Experimental infection of chickens with adenoviruses isolated from tenosynovitis

Abstract

Two adenoviruses isolated as the only viruses from the hock joints of chickens in outbreaks of tenosynovitis were tested for their ability to cause experimental tenosynovitis in chickens. It was previously shown that they were capable of growth in tendon organ cultures. One strain, designated 92, was used for infection of specific pathogen-free light hybrid chicks either in ovo at 17 days incubation or at 1-day-old orally or via the footpad. It was also used for infection of commercial broiler chicks at 1-day-old via the oral or footpad routes. The other virus, strain PS, was similarly used for infection of broiler chicks via the same routes. In none of the experiments did clinical signs or lesions of tenosynovitis develop other than transient inflammatory changes in the tissues and there was no evidence of prolonged virus persistence in hock joints. Of the tissues examined for virus, persistence was greatest in the gut.

Identification of a new reovirus causing substantial losses in broiler production in France, despite routine vaccination of breeders

“…In a few of the samples, also FAdVs were found without any link to the clinical and pathological data, confirming earlier experimental data that FAdVs cannot induce this disease (Jones and Georgiou 1984). Furthermore, no clinical signs of FAdV infection were observed in the field.…”

The outcome of experimentally induced inclusion body hepatitis (IBH) by fowl aviadenoviruses (FAdVs) is crucially influenced by the genetic background of the host

“…Genetically different chickens were used earlier to investigate IBH in experimental studies [ 16 – 20 ]. However, in nearly all of these studies broilers of commercial origin were used, whose serological status regarding maternal antibodies against FAdVs was either positive or unknown [ 16 , 18 – 20 ]. Exceptional to this, Cook [ 17 ] used different chicken breeds of SPF and non-SPF origin to study the influence of host, age and route of inoculation on the outcome of a FAdV infection.…”

Outbreak of gizzard erosion associated with fowl adenovirus infection in Korea

“…The pathogenesis of FAdV infection is affected by the serotypes or genotypes involved (McFerran, 1997). Although most avian adenoviruses are considered opportunistic pathogens and do not produce clinical signs when inoculated into birds by themselves, some are considered primary pathogens, such as the ones responsible for inclusion body hepatitis, hydropericardium syndrome, respiratory disease, necrotizing pancreatitis, and adenoviral gizzard erosion in chickens and other birds (McFerran et al, 1971;Jones and Georgiou, 1984;Anjum et al, 1989).…”