Oral toxicities of lauric acid and certain lauric acid derivatives

Fitzhugh, O. Garth; Schouboe, Paul J.; Nelson, Arthur A.

doi:10.1016/0041-008x(60)90071-5

Cited by 27 publications

(11 citation statements)

References 11 publications

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“…Eagle and Poling (1956) and Poling et al (1956) revealed the decreased of growth rate and increased the mortality in rats, hamsters and rabbits fed polyoxythelene-20 sorbitan mono-laurate from 5 to 25% of their feeding levels. Fitzhugh et al (1960) demonstrated the decreasing body weight and toxicity in rats fed sorbitan mono-laurate (Span 20) and polyoxyethelene-20 monolaurate (G-2129) with lauric acid as emulsifiers. Ruckman et al (2004) further observed that an LAE, lowered body weight and food consumption during the first week in rats when received 1143 and 1286 mg/kg/day.…”

Section: Discussionmentioning

confidence: 99%

Lauroyl-l-aspartate decreased food intake and body temperature in neonatal chicks

Erwan

Chowdhury

Ito

et al. 2013

Pharmacology Biochemistry and Behavior

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We hypothesized that the effects of L- and D-amino acids might be influenced when conjugated with fatty acid. Thus, the effects of oral administration of lauroyl-L-aspartate (Lau-L-Asp) as well as lauroyl-D-aspartate (Lau-D-Asp) were examined. In Experiment 1, oral administration of both Lau-L-Asp and Lau-D-Asp decreased food intake while L- or D-Asp did not influence food intake. Interestingly, only Lau-L-Asp decreased body temperature. Experiment 2 was conducted to determine whether non-conjugated mixture of L-Asp plus lauric acid has same effects under ad libitum feeding conditions. Lau-L-Asp decreased food intake and body temperature, but L-Asp plus lauric acid did not show any effect studied. In Experiment 3, we found that Lau-L-Asp declined food intake as well as time-dependently suppressed the body temperature in fasted chicks. However, L-Asp plus lauric acid did not show any effect. These results suggest that Lau-L-Asp may exert anorexigenic and hypothermic actions in chicks.

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Section: Discussionmentioning

confidence: 99%

Lauroyl-l-aspartate decreased food intake and body temperature in neonatal chicks

Erwan

Chowdhury

Ito

et al. 2013

Pharmacology Biochemistry and Behavior

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“…Capric acid was also included in this study but only in mixtures with caprylic acid and these were classified as irritants. In another study lauric acid could not be found harmful, after ingestion in rats [36]. Yet another in vitro study confirmed the relative nontoxicity of lauric acid and also showed the same for capric acid [37].…”

Section: Resultsmentioning

confidence: 72%

Catanionic aggregates formed from drugs and lauric or capric acids enable prolonged release from gels

Dew

Bramer

Edsman

2008

Journal of Colloid and Interface Science

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“…246 Dodecanoic acid was analysed for toxic effects in male and female Osborne-Mendel rats. [26] Test 247 animals were administered the carboxylic acid in their diet over a period of 18 weeks, at 248 concentrations 0 and 10% (approximating to 10000 mg/kg/day…”

Section: Saturated Short-to Medium-chain Carboxylic Acidsmentioning

confidence: 99%

Read-across of 90-day rodent repeated-dose toxicity: A case study for selected simple aryl alcohol alkyl carboxylic acid esters

Firman

Patel

Date

et al. 2018

Computational Toxicology

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Aryl alcohol alkyl carboxylic acid esters constitute a wide-employed class of fragrance materials. Outcomes presented within this study illustrate formulation of a read-across protocol for 90-day, repeat-dose toxicity within a series of these compounds, extending in scope to the dodecanoic acid esters of both benzyl and 2-phenylethyl alcohol. Central to the filling of data gaps is the hypothesis that adverse impact-mediated through mechanisms analogous to narcosis-associated non-specific basal cytotoxicity-is as a consequence of the hydrolysis of parent compounds to their corresponding alcohol. High-quality in vivo data (equivalent to either OECD Test Guideline 408 or 411) relating the toxicodynamic and toxicokinetic profiles of benzyl alcohol, 2-phenylethyl alcohol and benzyl acetate within rodents were retrieved, permitting extrapolation to each ester derivative with great confidence. NOAEL values of 250-500 mg/kg/day were assigned to esters, with a greater toxicity present within females. In order to greater enhance reliability, further theoretical support for the read-across prediction is provided through the integration, where appropriate, of in vitro and in silico data.

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Oral toxicities of lauric acid and certain lauric acid derivatives

Cited by 27 publications

References 11 publications

Lauroyl-l-aspartate decreased food intake and body temperature in neonatal chicks

Lauroyl-l-aspartate decreased food intake and body temperature in neonatal chicks

Catanionic aggregates formed from drugs and lauric or capric acids enable prolonged release from gels

Read-across of 90-day rodent repeated-dose toxicity: A case study for selected simple aryl alcohol alkyl carboxylic acid esters

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