Lauroyl-l-aspartate decreased food intake and body temperature in neonatal chicks

Abstract

We hypothesized that the effects of L- and D-amino acids might be influenced when conjugated with fatty acid. Thus, the effects of oral administration of lauroyl-L-aspartate (Lau-L-Asp) as well as lauroyl-D-aspartate (Lau-D-Asp) were examined. In Experiment 1, oral administration of both Lau-L-Asp and Lau-D-Asp decreased food intake while L- or D-Asp did not influence food intake. Interestingly, only Lau-L-Asp decreased body temperature. Experiment 2 was conducted to determine whether non-conjugated mixture of L-Asp plus lauric acid has same effects under ad libitum feeding conditions. Lau-L-Asp decreased food intake and body temperature, but L-Asp plus lauric acid did not show any effect studied. In Experiment 3, we found that Lau-L-Asp declined food intake as well as time-dependently suppressed the body temperature in fasted chicks. However, L-Asp plus lauric acid did not show any effect. These results suggest that Lau-L-Asp may exert anorexigenic and hypothermic actions in chicks.

Oral administration of D-aspartate, but not L-aspartate, depresses rectal temperature and alters plasma metabolites in chicks

“…The results of the current experiments confirmed previous findings which showed that oral administration of L-Asp did not decrease rectal temperature in rats (Koyuncuoğlu et al, 1982a;Koyuncuoğlu and Berkman, 1982). However, we recently found that when L-Asp was chemically conjugated with lauric acid, a medium-chain fatty acid (Lauroyl-L-Asp), it had the potential to decrease body temperature (Erwan et al, 2013a). Thus, the chemical modification of L-Asp assists in its development of new functions.…”

Orally Administered D-Aspartate Depresses Rectal Temperature and Alters Plasma Triacylglycerol and Glucose Concentrations in Broiler Chicks

“…The result was accordance with the previous findings that oral administration of L-Asp did not decrease rectal temperature in rats ( Koyuncuoğlu et al , 1982a ; Koyuncuoğlu and Berkman, 1982 ) and in layer chicks ( Erwan et al , 2014a ). Interestingly, we have found that when L-Asp was chemically conjugated with lauric acid, a medium-chain fatty acid, then it enabled decreasing body temperature in layer chicks ( Erwan et al , 2013b ). Thus, it could be suggested that the chemical structure of L-Asp is not designed to influence body temperature but esterified L-Asp may have that potential.…”

“…The injection of D-Asp but not L-Asp released arginine vasopressin (AVP) in rats ( Koyuncuoğlu et al , 1984 ). We have revealed the differences of L-Asp and D-Asp on stress response, feed intake and regulation of body temperature ( Erwan et al , 2012 , 2013a , 2013b , 2014). Further it was found that the mechanism of stress attenuating function of L- and D-Asp possibly occurs through different receptors ( Erwan et al , 2012 , 2014b ).…”

The Potency of Oral Administration of L-Citrulline as Anti Heat Stress Agent in KUB Chickens.

“…Several nutritional strategies have been reported to overcome the adverse effects of heat stress in poultry (Teeter and Belay, 1996;Yahav, 2000;Erwan et al, 2013aErwan et al, , 2014Erwan et al, , 2017Chowdhury et al, 2015). Heat stress reduces laying percentage, egg size, eggshell durability, and body weight gain, as well as increases mortality in layers (Sterling et al, 2003;Lin et al, 2004;Franco-Jimenez and Beck, 2007).…”