Orally Administered D-Aspartate Depresses Rectal Temperature and Alters Plasma Triacylglycerol and Glucose Concentrations in Broiler Chicks

Abstract

L-Aspartate (L-Asp), D-aspartate (D-Asp) or their chemical conjugates plays important physiological roles in regulating food intake, plasma metabolites and thermoregulation in animals. However, there are very few studies available in layers and no reports have been found in broilers. Broilers are very important commercial birds for meat production, so effects of L-or D-Asp in broilers would provide new physiological insight of this strain. Therefore, the purpose of this study was to determine the effect of oral administration of L-or D-Asp on feed intake, rectal temperature and some plasma metabolites in broiler chicks. Broiler chicks (5 days old) were orally administered with different doses (0, 3.75, 7.5 and 15 mmol/kg body weight) of L-or D-Asp. At 120 min after administration of L-or D-Asp, the blood was immediately collected through the jugular vein. The rectal temperature of chicks was measured at 30, 60 and 120 min after administration using a digital thermometer with an accuracy of ±0.1℃, by inserting the thermistor probe in the rectum to a depth of 2 cm. A repeated-measures two-way ANOVA was applied for the analysis of feed intake and rectal temperature. Plasma metabolites were statistically analyzed by one-way ANOVA and regression equations. The study showed that oral administration of both L-and D-Asp did not alter feed intake. However, D-Asp, but not L-Asp, dose-dependently decreased the rectal temperature in chicks. It was also found that DAsp increased plasma glucose and decreased triacylglycerol concentrations. The changes in plasma metabolites further indicate that D-Asp treatment modulates the energy metabolism in broiler chicks. In conclusion, D-Asp may be a beneficial nutrient not only for layers but also for broilers, since orally administered D-Asp lowered rectal temperature without reducing feed intake.

Interrelationship of myo-inositol pathways with systemic metabolic conditions in two strains of high-performance laying hens during their productive life span

“…Plasma MI was positively high-strong associated with aspartate, spermidine and carnitine and medium-strong associated with taurine, hexoses, lysoPC a C16:1 and spermine. Orally applied d -aspartate lowered body temperature and plasma triglycerides, while plasma glucose increased, suggesting that thereby, energy metabolism was modulated by d -aspartate in broilers 42 . However, it is unclear to which proportion d - and l -enantiomers of this amino acid exist in plasma of laying hens.…”

Subtitusi Krokot (Portulaca oleracea L.) dalam Ransum terhadap Kandungan Kolesterol Daging, Darah dan Trigliserida pada Ayam Broiler

“…Berdasarkan pendapat tersebut, dapat dikatakan bahwa hasil penelitian ini menunjukkan kadar total kolesterol masih dalam batas normal berkisar 157 mg/dl -185,90 mg/dl yang diperlihatkan pada tabel 2. Dan juga masih lebih rendah jika dibandingkan dengan sejumlah penelitian yang telah dilakukan sebelumnya sebagaimana pendapat Mustikaningsih (2010) berkisar antara 260 mg/dl-310 mg/dl dan juga menurut Erwan et al, (2017) menyatakan bahwa kandungan kolesterol darah ayam berkisar antara 200-232 mg/dl sementara menurut Fattah et al, (2008) berkisar antara 316,83-393,33 mg/dl dan Hasanuddin et al, (2013) berkisar anatara 215,39-278 mg/dl. Dengan demikian dapat dikatakan bahwa kadar kolesterol darah ayam pada hasil penelitian ini masih dalam kisaran batas normal dan masih lebih rendah dari penelitian lainnya.…”

Effects of substitution of corn for commercial ration on performance and plasma cholesterol in KUB chicken

“…Based on statistical analysis, there is no effect of experimental rations TCHO levels (p>0.05). Study of plasma metabolites in bird enables metabolic change to be evaluated that are due to the effects of many factors, including pharmacological condition physiological state, age, husbandry condition, and genetic type (Meluzzi et al, 1991;Gayathri et al, 2004;Erwan et al, 2014Erwan et al, , 2017Erwan et al, , 2020. The average TCHO level in the control and substitution with 30% corn was 154.52 mg/dl and 166.42 mg/dl included in the normal range according to finding of Mangisah (2003) who explained that normal chicken blood cholesterol levels ranged from 125-200 mg/dl.…”