Oral administration of D-aspartate, but not L-aspartate, depresses rectal temperature and alters plasma metabolites in chicks

Erwan, Edi; Chowdhury, Vishwajit S.; Nagasawa, Mao; Goda, Ryosei; Otsuka, Tsuyoshi; Yasuo, Shinobu; Furuse, Mitsuhiro

doi:10.1016/j.lfs.2014.05.015

Cited by 31 publications

(27 citation statements)

References 57 publications

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“…Consistent with previous research (Erwan et al, 2014a), plasma TG was found to be significantly decreased with the oral administration of D-Asp in the current study. Studies with rat (Koyuncuoglu et al, 1982b) and dogs (Shida et al, 1977) clearly showed the effect of decreasing plasma TG resulted hypothermia.…”

Section: Discussionsupporting

confidence: 93%

“…Studies with rat (Koyuncuoglu et al, 1982b) and dogs (Shida et al, 1977) clearly showed the effect of decreasing plasma TG resulted hypothermia. It was further confirmed in this study that oral administration of D-Asp increased glucose (Table 2) as observed in layer chicks (Erwan et al, 2014a). A positive correlation between the dose of D-Asp and glucose suggest that D-Asp might have increased plasma glucose.…”

Section: Discussionsupporting

confidence: 86%

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Orally Administered D-Aspartate Depresses Rectal Temperature and Alters Plasma Triacylglycerol and Glucose Concentrations in Broiler Chicks

et al. 2017

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L-Aspartate (L-Asp), D-aspartate (D-Asp) or their chemical conjugates plays important physiological roles in regulating food intake, plasma metabolites and thermoregulation in animals. However, there are very few studies available in layers and no reports have been found in broilers. Broilers are very important commercial birds for meat production, so effects of L-or D-Asp in broilers would provide new physiological insight of this strain. Therefore, the purpose of this study was to determine the effect of oral administration of L-or D-Asp on feed intake, rectal temperature and some plasma metabolites in broiler chicks. Broiler chicks (5 days old) were orally administered with different doses (0, 3.75, 7.5 and 15 mmol/kg body weight) of L-or D-Asp. At 120 min after administration of L-or D-Asp, the blood was immediately collected through the jugular vein. The rectal temperature of chicks was measured at 30, 60 and 120 min after administration using a digital thermometer with an accuracy of ±0.1℃, by inserting the thermistor probe in the rectum to a depth of 2 cm. A repeated-measures two-way ANOVA was applied for the analysis of feed intake and rectal temperature. Plasma metabolites were statistically analyzed by one-way ANOVA and regression equations. The study showed that oral administration of both L-and D-Asp did not alter feed intake. However, D-Asp, but not L-Asp, dose-dependently decreased the rectal temperature in chicks. It was also found that DAsp increased plasma glucose and decreased triacylglycerol concentrations. The changes in plasma metabolites further indicate that D-Asp treatment modulates the energy metabolism in broiler chicks. In conclusion, D-Asp may be a beneficial nutrient not only for layers but also for broilers, since orally administered D-Asp lowered rectal temperature without reducing feed intake.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 86%

Orally Administered D-Aspartate Depresses Rectal Temperature and Alters Plasma Triacylglycerol and Glucose Concentrations in Broiler Chicks

et al. 2017

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“…Amino acids have some roles in reducing body temperature in chicks (Erwan et al. ; Chowdhury et al. , ).…”

Section: Discussionmentioning

confidence: 99%

“…Recently, D‐aspartate (Erwan et al. ) and L‐citrulline (Chowdhury et al. ) have been found to play important roles in regulating body temperature and affording thermotolerance in chicks.…”

Section: Introductionmentioning

confidence: 99%

Central NPY ‐Y5 sub‐receptor partially functions as a mediator of NPY ‐induced hypothermia and affords thermotolerance in heat‐exposed fasted chicks

et al. 2017

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Exposure of chicks to a high ambient temperature (HT) has previously been shown to increase neuropeptide Y (NPY) mRNA expression in the brain. Furthermore, it was found that NPY has anti‐stress functions in heat‐exposed fasted chicks. The aim of the study was to reveal the role of central administration of NPY on thermotolerance ability and the induction of heat‐shock protein (HSP) and NPY sub‐receptors (NPYSRs) in fasted chicks with the contribution of plasma metabolite changes. Six‐ or seven‐day‐old chicks were centrally injected with 0 or 375 pmol of NPY and exposed to either HT (35 ± 1°C) or control thermoneutral temperature (CT: 30 ± 1°C) for 60 min while fasted. NPY reduced body temperature under both CT and HT. NPY enhanced the brain mRNA expression of HSP‐70 and ‐90, as well as of NPYSRs‐Y5, ‐Y6, and ‐Y7, but not ‐Y1, ‐Y2, and ‐Y4, under CT and HT. A coinjection of an NPYSR‐Y5 antagonist (CGP71683) and NPY (375 pmol) attenuated the NPY‐induced hypothermia. Furthermore, central NPY decreased plasma glucose and triacylglycerol under CT and HT and kept plasma corticosterone and epinephrine lower under HT. NPY increased plasma taurine and anserine concentrations. In conclusion, brain NPYSR‐Y5 partially afforded protective thermotolerance in heat‐exposed fasted chicks. The NPY‐mediated reduction in plasma glucose and stress hormone levels and the increase in free amino acids in plasma further suggest that NPY might potentially play a role in minimizing heat stress in fasted chicks.

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“…Therefore, studies on the hypothermic functions of non-crystallized L-Cit might provide useful information. Erwan et al (2014) reported that oral administration of D-aspartate (D-Asp), another hypothermic factor, lowered the body temperature of chicks both under a control thermoneutral temperature (CT) and HT. In addition, the administration of live bacteria into an animal's digestive tract has long been reported to exert beneficial effects on the growth and performance of the host.…”

Section: Introductionmentioning

confidence: 99%

Oral Administration of a Medium Containing L-Citrulline-producing Live Bacteria Reduces Body Temperature in Chicks

et al. 2019

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Recently, we showed that oral administration of crystallized L-citrulline (L-Cit) caused hypothermia under a control thermoneutral temperature (CT) and provided thermotolerance under high ambient temperature (HT) in chicks. The aim of this study was to clarify whether oral administration of a medium containing L-Cit-producing live bacteria can reduce body temperature in chicks under CT. In Experiment 1, 7-day-old chicks were orally administered either a medium (containing mainly L-Cit-producing live bacteria and 277 mM L-Cit) or an equimolar amount of L-Cit to determine their effects on body temperature (acute treatment). In Experiment 2, chicks were subjected to the same treatment from 7 to 13 days of age (chronic treatment). Rectal and surface body temperatures were recorded daily after 1 h of treatment. Both acute and chronic oral administration of the medium, but not of the equimolar amount of L-Cit, significantly reduced the rectal and surface body temperatures of the chicks. Chronic administration of the medium resulted in consistently low rectal and surface body temperatures during the entire experimental period. In conclusion, acute or chronic administration of the medium containing L-Cit-producing live bacteria, but not of the equimolar amount of L-Cit, reduced the rectal and surface body temperatures of the chicks. Our results suggest that medium containing L-Cit-producing live bacteria can be used as a new feed supplement for lowering the body temperature of chicks.

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Oral administration of D-aspartate, but not L-aspartate, depresses rectal temperature and alters plasma metabolites in chicks

Abstract: These results suggest that oral administration of D-Asp may play a potent role in reducing body temperature under both normal and HT conditions. The alteration of plasma metabolites further indicates that D-Asp may contribute to the regulation of metabolic activity in chicks.

Cited by 31 publications

References 57 publications

Orally Administered D-Aspartate Depresses Rectal Temperature and Alters Plasma Triacylglycerol and Glucose Concentrations in Broiler Chicks

Orally Administered D-Aspartate Depresses Rectal Temperature and Alters Plasma Triacylglycerol and Glucose Concentrations in Broiler Chicks

Central NPY ‐Y5 sub‐receptor partially functions as a mediator of NPY ‐induced hypothermia and affords thermotolerance in heat‐exposed fasted chicks

Oral Administration of a Medium Containing L-Citrulline-producing Live Bacteria Reduces Body Temperature in Chicks

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