Catanionic aggregates formed from drugs and lauric or capric acids enable prolonged release from gels

Two modes of fatty acid binding to bovine β‐lactoglobulin—crystallographic and spectroscopic studies

“…Capric acid decreases the intestinal absorption of cholesterol and slows cholesterol synthesis in the liver (Dasgupta and Bhattacharyya, 2009). Capric acid in water forms anionic vesicles that could help prolong drug release in the body or have positive effect on drug uptake from digestive system (Dew et al, 2008;Maher et al, 2009). It was also postulated that capric acid could have vasorelaxant activity (White et al, 1991).…”

Bioactive Formulations with Sugar‐Derived Surfactants: A New Approach for Photoprotection and Controlled Release of Promethazine

“…Edsman et al have also shown the possibility to apply catanionic aggregates for prolonged drug release from gel. In their studies, two antihistamines, orphenadrine and diphenhydramine, were associated with SDS26–28 or fatty acids 29. The modified rheological properties of the formulations allowed delaying the release of drugs.…”

Novel gel formulations with catanionic aggregates enable prolonged drug release and reduced skin permeation

“…The filled containers were covered with a mesh size plastic net and a coarse plastic net. A detailed description of this equipment can be found elsewhere [6] . The filled gel containers were submerged in 500 ml 37 ± 0.5°C 150 m m sodium chloride solution, which was stirred at 20 rev/min using a Pharma Test PTW II USP bath (Pharma Test Apparatebau, Hainburg, Germany).…”

“…Drug molecules in gels normally diffuse at rates comparable with those in pure water so to benefit from the extended contact time a prolonged drug release is desired. Recently, catanionic aggregates, formed from a drug substance and an oppositely charged surfactant, have been used to prolong the drug release from gels [3–8] . Catanionic aggregates are formed spontaneously upon mixing solutions of a variety of oppositely charged surfactants [9–11] .…”