Oral submucous fibrosis: its pathogenesis and management

Canniff, J. P.; Harvey, W. Proctor; Harris, Malcolm

doi:10.1038/sj.bdj.4805876

Cited by 228 publications

(201 citation statements)

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“…It has been described that areca quid as well as its components affect fibroblast proliferation, increase collagen synthesis, and promote an accumulation of ECM components in the oral mucosa. Many researchers have reported the etiology of submucousal fibrosis as an increase of collagen deposition resultant to a decrease of collagen degradation [4]. TIMPs play an important role in various physiological processes that involve tissue remodeling.…”

Section: Discussionmentioning

confidence: 99%

Therapeutic Interventions in Oral Submucous Fibrosis: An Experimental and Clinical Study

Singh

Mohammad

Pant³

et al. 2014

J. Maxillofac. Oral Surg.

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Introduction Oral submucous fibrosis (OSF) is a chronic debilitating disease and premalignant condition of the oral cavity and is a serious public health issue in India and many parts of the world. The treatment is still elusive and empirical because of poorly understood etiopathogenesis, which is believed to be multifactorial including areca nut chewing, ingestion of chillies, genetic and immunologic processes, nutritional deficiencies, and many others. The present investigations was focused to understand the possible therapeutic interventions of anti-OSF agents in arecoline induced experimental in vitro model of OSF and clinical application of these anti-OSF agents in the restoration of various grade of the disease. Materials and Methods The 127 subjects were selected from patients who visited the OPD of Department of Oral and Maxillofacial Surgery, Faculty of Dental Sciences, K.G. Medical University, Lucknow. Further the subjects were divided in two groups on the basis of clinical examination. Group-1 subjects showed presence of fibrosis bands in the labial and/or buccal mucosa, loss of elasticity, difficulty to open the mouth and had a habit chewing arecanut in some form. Group-2 subjects had no habit of chewing areca-nut, were apparently healthy with no mucosal disorder. The samples were collected and were immediately transported to Indian Institute of Toxicology Research, Lucknow, for isolation and cultivation of primary cultures of mucosal fibroblast cells. Then isolation and cultivation of oral mucosal fibroblast, identification of non-cytotoxic doses of arecoline, real time PCR, immunocytochemistry, cytokine determination in culture cells, western blot analyses, functional activity of collagenase, lysyl oxidase enzyme activity, collagen beads assay, cyclooxygenase (COX-2) expression analysis was done. Results and Conclusions This study, shows that the reduction of phagocytic cells was strongly related to the arecoline levels in fibroblast culture when we exposed arecoline to normal oral mucosal cells (NOMC) and cells from OSF patient. An enhancement of phagocytic cells was observed following the pre exposure of cells to 1 lM dexamethasone, a glucocorticoids, In this study, histologic evidence is presented which supports the finding that COX-2 expression is upregulated in OSF specimens compared to normal oral submucosal cells. Strong immunostaining for COX-2 was detected in arecoline exposed NOMC and cells from OSF patient. Areca nut extract up-regulates prostaglandin production, cyclooxygenase-2 mRNA and protein expression of human oral keratinocytes. The number of phagocytic cells and phagocytic activity in cultured human oral fibroblasts from OSF site was lower than the fibroblasts from the normal regions of the same person.

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Section: Discussionmentioning

confidence: 99%

Therapeutic Interventions in Oral Submucous Fibrosis: An Experimental and Clinical Study

Singh

Mohammad

Pant³

et al. 2014

J. Maxillofac. Oral Surg.

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“…5). The interincisal opening improved significantly from a mean (range) of 11 (3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19) mm to 39 (23-48) mm at the end of 6 months and persisted without relapse for 1 years of follow up (Table 1).…”

Section: Resultsmentioning

confidence: 93%

“…Bilateral radial forearm free flaps are hairy, 40% of patients require secondary debulking procedures, and the facilities for free tissue transfer are not universally available [8]. Canniff and Harvey [9] recommended temporal myotomy or coronoidectomy to release severe trismus caused by the atrophic changes in the tendon of temporalis muscle secondary to the disease.…”

Section: Discussionmentioning

confidence: 99%

Extended Nasolabial Flaps in the Management of Oral Submucous Fibrosis

Agarwal¹,

Gupta²,

Tiwari³

2011

J. Maxillofac. Oral Surg.

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Purpose We evaluated the use of extended nasolabial flaps in the management of oral submucous fibrosis. Methods We evaluated the use of extended nasolabial flaps in the management of 27 randomly selected patients with histologically confirmed oral submucous fibrosis. They all had interincisal opening of less than 20 mm and were treated by bilateral release of fibrous bands and extended grafting with a nasolabial flap. All patients had postoperative physiotherapy, and were followed up for one year.Results Their interincisal opening improved significantly from a mean of 11mm (range 3-19) to a mean of 39 mm (range 23-48). Conclusions The procedure was effective in the management of patients with oral submucous fibrosis, the main disadvantage being the extraoral scars.

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“…Auto-antibodies to gastric, parietal, and thyroid microsomal and antinuclear antibodies have also been found in 65% of patients with OSMF. 8 Diagnosis of OSMF is usually based on the clinical signs and symptoms, which include; oral ulceration, burning sensation (particularly with spicy foods), paleness of the oral mucosa, and occasional leukoplakia. The most characteristic feature is the marked vertical fibrous ridge formation within the cheeks, and board like stiffness of the buccal mucosa.…”

Section: Auto-antibodiesmentioning

confidence: 99%