Oral submucous fibrosis in a 11-year-old Bangladeshi girl living in the United Kingdom

Shah, Bina; Lewis, M J; Bedi, Raman

doi:10.1038/sj.bdj.4801117a

Cited by 12 publications

(16 citation statements)

References 7 publications

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“…More than 90% of these malignancies representing a squamous cell carcinoma (SCC), which are often preceded by pre-existing oral lesions termed as potentially malignant disorders of the oral mucosa such as oral sub mucous fibrosis (OSMF) [1]. OSMF occurs most commonly in South East Asia, but many cases, it has been reported worldwide, in countries like China, UK, Kenya, Saudi Arabia, Pakistan and other parts of the world [2]. In India, about 5 millions people suffer from this disease [3].…”

Section: Introductionmentioning

confidence: 99%

Comparative study between the Hybrid Capture II test and PCR based assay for the detection of human papillomavirus DNA in oral submucous fibrosis and oral squamous cell carcinoma

Chaudhary

Pandya

Mehrotra

et al. 2010

Virol J

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BackgroundOral malignancy is a major global health problem. Besides the main risk factors of tobacco, smoking and alcohol, infection by human papillomavirus (HPV) and genetic alterations are likely to play an important role in these lesions. The purpose of this study was to compare the efficacy of HC-II assay and PCR for the detection of specific HPV type (HPV 16 E6) in OSMF and OSCC cases as well as find out the prevalence of the high risk HPV (HR-HPV) in these lesions.Methods and materialsFour hundred and thirty patients of the potentially malignant and malignant oral lesions were taken from the Department of Otorhinolaryngology, Moti Lal Nehru Medical College, Allahabad, India from Sept 2007-March 2010. Of which 208 cases were oral submucous fibrosis (OSMF) and 222 cases were oral squamous cell carcinoma (OSCC). The HC-II assay and PCR were used for the detection of HR-HPV DNA.ResultThe overall prevalence of HR-HPV 16 E6 DNA positivity was nearly 26% by PCR and 27.4% by the HC-II assay in case of potentially malignant disorder of the oral lesions such as OSMF. However, in case of malignant oral lesions such as OSCC, 32.4% HPV 16 E6 positive by PCR and 31.4% by the HC-II assay. In case of OSMF, the two test gave concordant result for 42 positive samples and 154 negative samples, with an overall level of agreement of 85.4% (Cohen's kappa = 66.83%, 95% CI 0.553-0.783). The sensitivity and specificity of the test were 73.7% and 92.05% (p < 0.00). In case of OSCC, the two test gave concordant result for 61 positive samples and 152 negative samples, with an overall level of agreement of 88.3% (Cohen's kappa = 79.29, 95% CI 0.769-0.939) and the sensitivity and specificity of the test were 87.14% and 92.76% (p < 0.00).ConclusionThis study concluded that slight difference was found between the positivity rate of HR-HPV infection detected by the HC-II and PCR assay in OSMF and OSCC cases and the HC II assay seemed to have better sensitivity in case of OSCC.

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Section: Introductionmentioning

confidence: 99%

Comparative study between the Hybrid Capture II test and PCR based assay for the detection of human papillomavirus DNA in oral submucous fibrosis and oral squamous cell carcinoma

Chaudhary

Pandya

Mehrotra

et al. 2010

Virol J

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“…Oral submucous fibrosis (OSMF) is a chronic disease of the oral cavity, which is characterized by an epithelial and subepithelial inflammatory reaction followed by fibroelastic changes in the submucosa [ 1 ]. This disease occurs most commonly in South East Asia but cases have been reported worldwide in countries like Kenya, China, UK, Saudi Arabia and other parts of the world [ 2 ]. In India, the authors earlier reported that oral submucous fibrosis constituted the highest number of patients in premalignant group in a tertiary level hospital based study at Allahabad [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Lipid profile in oral submucous fibrosis

et al. 2009

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“…9 No sex predilection is established in children but a small number of studies reported areca nut chewing to be more in boys. 9 Shah et al (2001) reported a case of OSMF in an 11-year-old Bangladeshi girl living in the UK. 10 Table 1 shows the details of OSMF patients reported in Pediatric age group all over world till date.…”

Section: Discussionmentioning

confidence: 99%

“…9 Shah et al (2001) reported a case of OSMF in an 11-year-old Bangladeshi girl living in the UK. 10 Table 1 shows the details of OSMF patients reported in Pediatric age group all over world till date. [9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24] Reviewing the literature no case has been reported with an interincisal opening less than 10 mm, 24 thus making this case to be the first incident case of OSMF in a child with least interincisal opening of 06 mm.…”

Section: Discussionmentioning

confidence: 99%

No age predilection for a disease like OSMF. A case report of 5-year-old child

Kariya

Khobragade²,

Sura

et al. 2020

Journal of Oral Biology and Craniofacial Research

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Background: Oral Sub Mucous Fibrosis (OSMF) is a clinical entity, well known since the time of Sushruta as 'Vidari'. OSMF is a chronic subtle disease that is associated with significant functional morbidity and an increased risk for malignancy. Generally, OSMF is considered as an adult disease, but recently Indian suburb area has reported incidence of 0.2-1.2 percent in pediatric age group as well. The pathogenesis of the disease is not well established, but is believed to be multifactorial. Areca nut chewing is considered as the major etiology amongst all. Children indulge in habit of chewing areca nuts due to its easy availability of different forms of multicolored attractive areca nut pouches in markets. Other factors involved in the consumption of Areca nut are levels of awareness, household environment, peer pressure, low cost, etc. Case presentation: A 5-year-old boy reported with the complaint of restricted mouth opening since 3-4 months. He had habit of chewing betel nut, a minimum of 2-3 sachets daily since one and a half years. He also complained of intolerance to spicy food. The oral mucosa was pale, opaque, blanched with a reduced mouth opening of interincisal width being 06 mm.Palate was fibrotic with shrunken uvula. Conclusion: This Case of OSMF in a 5-year-old boy is reported to be the first incidence of OSMF in a child with least interincisal opening of 06 mm.

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Oral submucous fibrosis in a 11-year-old Bangladeshi girl living in the United Kingdom

Cited by 12 publications

References 7 publications

Comparative study between the Hybrid Capture II test and PCR based assay for the detection of human papillomavirus DNA in oral submucous fibrosis and oral squamous cell carcinoma

Comparative study between the Hybrid Capture II test and PCR based assay for the detection of human papillomavirus DNA in oral submucous fibrosis and oral squamous cell carcinoma

Lipid profile in oral submucous fibrosis

No age predilection for a disease like OSMF. A case report of 5-year-old child

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