Lipid profile in oral submucous fibrosis

Mehrotra, Ravi; Pandya, Sunil K; Chaudhary, Ajay Kumar; Singh, Himanshu; Jaiswal, Ritesh Kumar; Singh, Magan; Gupta, S K; Singh, Mamta

doi:10.1186/1476-511x-8-29

Cited by 32 publications

(33 citation statements)

References 19 publications

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“…TC and LDL-C values were higher in cases than in controls, while HDL-C value was lower in cases than in controls; however the difference in both were not significant. These results were comparable to the studies of lipid profile with submucosal fibrosis and breast cancer by Mehrotra et al (2009);Dabrowa et al (2011);Laisupasin et al (2013). Cconsidering varying grades of cervical cancer, TC and LDL-C increased from WDSCC to PDSCC but was not statistically significant.…”

Section: Discussionsupporting

confidence: 80%

“…Hence it was concluded that estimation of lipid profile can be a good marker for increased cell turnover (Nayak et al, 2000). In a study of lipid profile and submucosal fibrosis, significant decrease in TC and HDL-C and significant increase in LDL-C and TG was observed (Mehrotra et al, 2009). In another study TC, TG and HDL-C showed significant decrease in oral cancer patients compared with controls with insignificant values of LDL-C.…”

Section: Discussionmentioning

confidence: 92%

“…In some malignant diseases, blood cholesterol undergoes early and significant changes. Low levels of cholesterol in the proliferating tissues and in blood compartments could be due to the process of carcinogenesis (Patel et al, 2004, Mehrotra et al, 2009Chawda et al, 2011, Singh et al, 2013. Alteration in cholesterol metabolism, increased synthesis of cholesterol, increased accumulation of cholesterol in tumour tissue with decreased serum levels of cholesterol esters are reported.…”

Section: Discussionmentioning

confidence: 99%

“…This affects essential constituents of the cell membrane leading to greater utilization of lipids including total cholesterol, lipoproteins and triglycerides for new membrane biogenesis. Cells fulfill these requirements either from circulation, by synthesis through the metabolism or from degradation of major lipoprotein fractions like VLDL, LDL or HDL (Patel et al, 2004;Mehrotra et al, 2009;Gupta et al, 2012;Singh et al, 2013). The antioxidant vitamins A and E have protective effects against lipid peroxidation (Patel et al, 2004).…”

Section: Discussionmentioning

confidence: 99%

“…LDL-C is involved in transport of 75% of cholesterol in blood, of which 80% is removed from blood by LDL-C receptors and 20% is deposited in arterial wall. HDL-C is associated with taking cholesterol out of blood (Patel et al, 2004;Mehrotra et al, 2009;Chawda et al, 2011;Singh et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

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Significance of the Plasma Lipid Profile in Cases of Carcinoma of Cervix: A Tertiary Hospital Based Study

Raju

Punnayanapalya²,

Mariyappa³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Asian Pac J Cancer Prev, 15 (8), 3779-3784 IntroductionCervical cancer is one of the leading cancer related death among women worldwide (Satija, 2013). Cervical cancer is the third most common cancer in women worldwide accounting for 9% of all female cancer and 9% death in females due to cervical cancer. Worldwide it is seventh cancer with estimated 530,000 new cases in 2008 accounting for 4% of cancer worldwide. More than 85% of the global burden is seen in developing countries compared to western countries and it accounts for 13% of all female cancers. In India, 134,000 were detected to have cervical cancer, out of which 72,825 women died of cervical cancer in 2008 (Globocan, 2008;Misra et al., 2009). At our institute cervical cancer accounts for about 17.5% of total cancers in females (Kalyani et al., 2010).Lipids are high energy yielding molecules and include fats and oils, waxes, phospholipids, steroids and other related compounds. Fats and oils are made from two kinds

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Section: Discussionsupporting

confidence: 80%

Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Significance of the Plasma Lipid Profile in Cases of Carcinoma of Cervix: A Tertiary Hospital Based Study

Raju

Punnayanapalya²,

Mariyappa³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Raman mapping of oral tissues for cancer diagnosis

Daniel

Aruna

David

et al. 2014

J Raman Spectroscopy

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Oral cancer having a high incidence and recurrence rate causes a potential threat and huge economic burden in Southeast Asia. In light of the aforementioned text, early and accurate diagnosis of this disease addressing molecular level changes would play a vital role in reducing the recurrence and increasing the survival rate. Raman spectroscopy has significant potential in the characterization and clinical diagnosis of normal and cancerous tissues at molecular level. To the best of our knowledge, to date, no study has been reported for Raman mapping of oral tissues. This study consistently showed the increased presence of glycogen, lipids, and proteins in all the normal oral tissues, whereas the nucleic acid content was found to be more in cancerous samples. The spectral data were exploited to construct pseudocolor images using principal component analysis and K‐means clustering. Thus, obtained Raman maps clearly delineated the tumor margins and was confirmed by the subsequent histopathological report of the hematoxylin–eosin stained samples. A blinded sample was mapped as well, and it showed a few pixels characteristic of malignancy. Upon histological evaluation, the blinded sample was reported as dysplastic, which was in agreement with the obtained Raman image. Hence, this study provides a firm basis to Raman spectral mapping for oral cancer diagnosis and for delineating the tumor margin. Copyright © 2014 John Wiley & Sons, Ltd.

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Serum Raman spectroscopy in experimental carcinogenesis hamster buccal pouch model: Exploring early diagnostic capability

Jadhav

Pansare

Hole

et al. 2022

J Raman Spectroscopy

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About two third of oral cancer cases present at advanced stages, emphasizing the need for screening tools for early diagnosis. Raman spectroscopy (RS) can prove an appropriate tool for early diagnosis as biochemical changes occur before morphological changes. Due to limitations with study of early oral cancer stages in human subjects, we performed a sequential carcinogenesis study in animal model. In the present study, we aim to probe early biochemical changes occurring during DMBA induced oral carcinogenesis in hamster buccal pouch model, using serum RS (SRS). Serum being systemic biofluid can reflect the true in vivo state, is minimally invasive and offers advantages of remote diagnosis and serial sampling. The female Syrian golden hamsters were treated with 0.5% DMBA and retro-orbital blood collection was performed every week for a period of 14 weeks. An increase in classification efficiency as the DMBA treatment progressed, with distinct classification of >70% seen as early as week 5 (W5), appreciably early to development of visual changes (W8-W10) was observed. Furthermore, the early treatment weeks (W1-W4) and healthy condition (W0) show no misclassifications with weeks exhibiting frank tumours (W9-W14), demonstrating efficacy of SRS to stratify healthy versus carcinogen exposure. The findings suggest that as oral carcinogenesis progresses, biochemical alterations in serum such as increasing protein and loss of lipid content can be detected by RS, highlighting the feasibility and utility of SRS in early oral cancer diagnosis. To our knowledge, this is the first study exploring the ex vivo sequential approach to gain insights into oral cancer progression.

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Lipid profile in oral submucous fibrosis

Cited by 32 publications

References 19 publications

Significance of the Plasma Lipid Profile in Cases of Carcinoma of Cervix: A Tertiary Hospital Based Study

Significance of the Plasma Lipid Profile in Cases of Carcinoma of Cervix: A Tertiary Hospital Based Study

Raman mapping of oral tissues for cancer diagnosis

Serum Raman spectroscopy in experimental carcinogenesis hamster buccal pouch model: Exploring early diagnostic capability

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