Asian Pac J Cancer Prev, 15 (8), 3779-3784 IntroductionCervical cancer is one of the leading cancer related death among women worldwide (Satija, 2013). Cervical cancer is the third most common cancer in women worldwide accounting for 9% of all female cancer and 9% death in females due to cervical cancer. Worldwide it is seventh cancer with estimated 530,000 new cases in 2008 accounting for 4% of cancer worldwide. More than 85% of the global burden is seen in developing countries compared to western countries and it accounts for 13% of all female cancers. In India, 134,000 were detected to have cervical cancer, out of which 72,825 women died of cervical cancer in 2008 (Globocan, 2008;Misra et al., 2009). At our institute cervical cancer accounts for about 17.5% of total cancers in females (Kalyani et al., 2010).Lipids are high energy yielding molecules and include fats and oils, waxes, phospholipids, steroids and other related compounds. Fats and oils are made from two kinds
Abstract-Objective:To study and to derive the significance of expression of p53, pRb and Ki-67 markers in various grades of cervical intraepithelial lesions and malignancy in a tertiary hospital situated in southern part of India which caters the rural and semi-urban population.Methods: A total of 120 cervical tissue samples were included. These represented normal, dysplasia and malignancy. Immunohistochemical staining was performed for p53, Ki-67 and pRb in formalin-fixed, paraffin-embedded tissue sections of the uterine cervix using horse-peroxidase method. Descriptive statistical analysis was done; significance was assessed at 5% level of significance. The mean value of the markers was compared between normal and pathological lesions separately using Independent "t" test. Results: There was significant association of p53 expression between normal cervical epithelium and low grade squamous intraepithelial lesion (LSIL) (p=0.023), squamous cell carcinoma (SCC) (p<0.001) and adenocarcinoma AC (p=0.004), but no significant association with high grade squamous intraepithelial lesion (HSIL) (p=0.09). In case of pRb(n) (n=nuclear) expression significant association was found when normal was compared with LSIL (p<0.001) and HSIL (p=0.001), no association was found with SCC (p=0.207) and AC (p=0.322). pRb(c) (c=cytoplasmic) expression showed significant association when normal was compared with HSIL(p=0.03), SCC (p<0.001) and AC (p<0.001), but no association was found with LSIL. Whereas Ki-67 expression showed highly significant association with LSIL (p=0.012), HSIL (p<0.001), SCC (p<0.001) and AC (p<0.001). Conclusion: p53 expression progressively increased from normal cervical epithelium to intraepithelial lesion to malignant lesion. pRb expression showed shift of expression of pRb(n) in intraepithelial lesions to expression of pRb(c) in HSIL to frank malignancy. Ki-67 expression was directly proportional to the degree of dysplasia to malignant lesion.
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