Summary:Hospital records of 120 patients undergoing aortic valve replacement were retrospectively reviewed for risk factors associated with early aortic valve replacement, Patients were separated into four groups (rheumatic, congcnital bicuspid. degenerative, and miscellaneous) based upon the morphologic etiology of aortic stenosis. Multiplc regression analysis was performed using age at surgcry as the dependent variable. lndependent variables for the study were race, gender, systemic hypertension, total triglyceride level, total serum cholesterol level, tobacco smoking history, diabetes mellitus, and angiographic coroiiary artery disease. In the rheumatic valve group only showed a statistically significant risk effect whereas in the congenital bicuspid valve group i u w , g n idcv.? and tri,qIycwicle.s were statistically correlated with age at surgcry. In the degenerative valve group ,qencIcr and .snioAiri,q were found to be statistically significant risk factors. The establishment of aortic stenosis risk factors might be an indication for clinical trials of risk factor modification i n patients with aortic stenosis.
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