Oral squamous cell carcinoma in children; review of an unusual entity

Outcomes of oral cavity squamous cell carcinoma in pediatric patients

“…Because of its rarity, the literature on OCSCC in these young patients is limited entirely to case reports1,3,8–16. Based on the available literature, researchers have argued that OCSCC in the pediatric and young adult population behaves more aggressively, and carries a worse prognosis3,5–8. However, it is unknown whether these case reports accurately reflect the natural history of pediatric OCSCC, or whether cases with poor outcome are over-represented in the literature.…”

“…However, there is disagreement in the literature regarding outcomes of OCSCC in pediatric and young patients. Many clinicians believe that this disease is particularly aggressive in young patients, and is associated with poorer survival compared to adults3,5–8. Because of the rarity of OCSCC in pediatric patients, the literature consists entirely of isolated case reports, many of which report poor outcomes1,3,8–16.…”

“…Many clinicians believe that this disease is particularly aggressive in young patients, and is associated with poorer survival compared to adults3,5–8. Because of the rarity of OCSCC in pediatric patients, the literature consists entirely of isolated case reports, many of which report poor outcomes1,3,8–16. Much of the opinion regarding OCSCC in this age group has been extrapolated from studies of young adults under 40 years of age7,17–22.…”

Pediatric head and neck squamous cell carcinoma: Report of 12 cases and illustrated review of literature

“…In the cohort of 69 patients of PHNSCC accumulated by literature review, gender was reported in 51 patients of whom 34 were male and 17 were female [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27]. The details of the published cases are summarized in Table 2.…”

“…Median age of the entire cohort was 17 years (Range: [8][9][10][11][12][13][14][15][16][17][18][19][20]. Gender predilection was skewed in favor of male (male:female ratio-11:1).Oral tongue 3 (25%) was the commonest sub site followed by soft palate 2 (17%) gingiva 2 (17%), supra glottis larynx 2 (17%) and one each of hard palate, buccal mucosa, floor of mouth (8.25% each).…”