Squamous Cell Carcinoma of the Oral Tongue in the Pediatric Age Group

Abstract

Objective To compare outcomes of a pediatric cohort of patients compared with a matched cohort of adult patients, all diagnosed as having squamous cell carcinoma (SCC) of the oral tongue. Outcomes of oral cancer in pediatric patients have not been studied, to our knowledge. Design Retrospective matched-pair cohort study. Setting Memorial Sloan-Kettering Cancer Center, New York, New York. Patients A total of 10 pediatric and 40 adult patients diagnosed as having SCC of the oral tongue. Main Outcome Measures Overall survival (OS), disease-specific survival (DSS), and recurrence-free survival (RFS). Results The 5-year OS was equivalent in the 2 groups: 70% in the pediatric group and 64% in the adult group (P=.97). The 5-year DSS was also equivalent: 80% in the pediatric group and 76% in the adult group (P=.90). The 5-year RFS was 70% in the pediatric group and 78% in the adult group (P=.54). Conclusions When pediatric and adult patients were matched for sex, tobacco use history, TNM status, surgical procedure, and adjuvant radiotherapy, outcomes for OS, DSS, and RFS were equivalent. Pediatric patients with SCC of the oral tongue should be treated similarly to adult patients.

Overview of Carcinomas in Adolescents: A Descriptive Study Over Twenty Years

“…Indeed, only patients with localized, completely resectable tumors have been successfully treated: 1/9 SCC of oral cavity. However, in previous studies, survival rates of oral cavity SCC were higher: 70% 5y-OS in the Memorial SloanKettering Cancer Centre series (10 tongues SCC, 3/10 with lymph node involvement) [22] and 75.3% 5y-OS in the SEER series (54 oral cavities SCC, 40% with lymph node spread) [23]. Lower OS may be explained in our series by more frequent lymph node involvement at diagnosis and the absence of radical surgery in most patients.…”

“…Lower OS may be explained in our series by more frequent lymph node involvement at diagnosis and the absence of radical surgery in most patients. SCC of oral cavity are rare in adolescents, but only convincing treatment according to guidelines in adults [22] could be efficient in such poor prognosis diseases. Adolescents with oral SCC have not better prognosis than adults, and consequently they need optimal treatment with complete surgery, even if sequelae are more important.…”

“…Only 2/7 patients with FL-HCC and 1/5 HCC were alive with a follow-up of 47, 77 and 74 months but after multiple recurrences treated with various combined therapies (multiple surgeries, chemotherapy, hyperthermic intraperitoneal chemotherapy, inhibitor tyrosine kinase, radiofrequency). The median survival of patients was 26 months (12-78) for FL-HCC and 16.5 months (8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25) for HCC.…”

Oral Mukozanın Malign Hastalıkları

“…Prognozu oldukça iyidir. Lateral olarak çevreye doğru yavaş büyümesi ve lenf nodlarına metastaz yapma riskinin düşük olması tümörün prognozunun iyi olduğunu gösterir 1,7,8 . Bazaloid SHK (bazoskuamöz hücreli karsinom) nadir rastlanan ve oral SHK'nın agresif formu olarak kabul edilen ayrı bir histopatolojik tablodur.…”

Matched-Pair Analysis of Open versus Laparoscopic Nephroureterectomy for Upper Urinary Tract Urothelial Cell Carcinoma

“…The approach was recently used to compare short-term outcomes in 22 pairs undergoing robotic nephroureterectomy or LNU for UUT-UCC [14]. It has also been used to compare lithotripsy and ureteroscopy for upper tract ureteric calculi [15] and to compare outcomes after chemotherapy in small numbers of patients with lymphoma [16], squamous cell carcinoma [17,18], primary glioblastoma [19] and macular degeneration [20]. It is therefore a valid approach with which to compare outcomes in rare conditions.…”