Pediatric head and neck squamous cell carcinoma: Report of 12 cases and illustrated review of literature

Bhanuprasad, V.; Mallick, Supriya; Bhasker, Suman; Mohanti, Bidhu Kalyan

doi:10.1016/j.ijporl.2015.05.031

Cited by 16 publications

(8 citation statements)

References 28 publications

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“…Nevertheless, high-grade MEC has to be differentiated from other high-grade carcinomas, including salivary duct carcinoma, adenocarcinoma not otherwise specified, squamous cell carcinoma, and epithelial-myoepithelial carcinoma. These neoplasms are very rare in paediatric age, and only squamous cell carcinoma and epithelial-myoepithelial carcinoma have been reported [4, 27, 42]. However, in our series, an accurate preoperative cytological diagnosis was rendered in all the 5 cases, and subsequently confirmed by the histological examination of the surgical samples, with a diagnostic sensitivity and specificity of 100%.…”

Section: Discussionmentioning

confidence: 53%

Fine-Needle Aspiration Cytology Is an Effective Diagnostic Tool in Paediatric Patients with Mucoepidermoid Carcinoma as Secondary Neoplasm

et al. 2020

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Background: Mucoepidermoid carcinoma (MEC) is the most common malignant salivary gland tumour in paediatric population, accounting for 16% of all cases. Patients affected by a previous solid or leukaemic neoplasm during their childhood may develop a second different tumour during the follow-up. In this setting, salivary gland MEC is relatively frequent, accounting for 6% of the second neoplasms in paediatric patients. Consequently, the occurrence of salivary gland nodules in paediatric patients with a previous neoplasm should be considered an event with a high risk of malignancy that poses peculiar diagnostic challenges. Summary: This study was designed to define clinical and instrumental findings and morphological features of MEC on fine-needle aspiration cytology (FNAC) samples in paediatric patients with and without a previous neoplasm. Five patients under 19 years are included in this series. FNAC was performed in all patients on a parotid nodule. We have identified 2 groups of patients: (a) 2 cases with previous history of malignancy (acute lymphoblastic leukaemia and Hodgkin lymphoma) and (b) 3 cases without previous malignant neoplasms. In all cases, a final diagnosis of MEC was rendered. Key Messages: MEC may occur as a second malignancy in paediatric patients. FNAC is certainly a valid and accurate diagnostic tool for this type of neoplasm, even in the paediatric age, allowing the correct management of the patients.

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Section: Discussionmentioning

confidence: 53%

Fine-Needle Aspiration Cytology Is an Effective Diagnostic Tool in Paediatric Patients with Mucoepidermoid Carcinoma as Secondary Neoplasm

et al. 2020

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“…Only reports including specific information on the age and gender of the patient and the site of the carcinoma were included (Table I). 1,[3][4][5] The ages of the patients varied between 6 and 19 years. There were 29 males and 13 females.…”

Section: Discussionmentioning

confidence: 99%

“…Oral squamous cell carcinoma (OSCC) predominantly affects individuals over 40 years of age and is extremely rare in patients younger than 20 years of age. 1,2 The diagnosis of OSCC in pediatric patients may present a significant challenge to the clinician, because it may be mistaken for a reactive lesion, which may cause a delay in diagnosis. 3,4 Other important considerations include careful treatment planning and prognosis and the possible long-term impact on the development of the facial structures, including teeth and jaws.…”

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confidence: 99%

Unusual presentation of squamous cell carcinoma of the maxilla in an 8-year-old child

Magalhaes

Somers

Sikorski

et al. 2016

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

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Oral squamous cell carcinoma (OSCC) is extremely rare in patients younger than 20 years of age. We present here a case of OSCC of the maxillary alveolar ridge in an otherwise healthy 8-year-old patient. The clinicohistologic presentation was not typical for mucosal SCC, and the possibility of an intrabony origin from the odontogenic epithelium was considered. The patient was treated with surgical resection, and treatment decisions were made with consideration of the need for eradication of tumor as well as tissue preservation to allow normal growth and development. A review of the literature indicated a preponderance of gingival-alveolar ridge as the site of OSCC in children with no known genetic predisposition to cancer. More studies of this rare subset of OSCC will help understand the underlying biology and guide treatment decisions.

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“…They have a huge tendency to get misdiagnosed or get wrongly diagnosed. Very few drug companies tend to invest into such rare diseases since it may be difficult to cover cost for developing therapeutics for such small and geographically diverse populations [7][8][9][10].…”

mentioning

confidence: 99%

“…Similarities exist between SRs of prevalence of rare diseases but individual conditions present unique challenges. A good knowledge of disease classification and historical nomenclature is essential for effective searching and screening [9][10]19]. Whether diagnosis is simple or complex, it should be clearly and fully reported, data extracted and compared with other studies reporting the same outcome.…”

mentioning

confidence: 99%

Understanding Systematic Reviews for Orphan Cancer Disorders-A Perspective

We¹

2018

TTSR

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OpinionThe United States Food and drugs administration defines a rare disease as any disorder that affects fewer than 200,000 Americans. The European definition is when a disease affects less than 1 in 2,000. These rare diseases poses lot of challenges in treatment decision making [1][2][3]. In particular Oncological disorders caused multitude of dilemma in clinical decision making. These rare cancers maybe difficult to characterize or define, the recruitment into clinical trials maybe difficult with lack of high quality evidence with very few centers with necessary expertise to manage and do research in these disorders [4][5][6]. Rare Oncological disorders may cause chronic illness, disability, and often premature death. They are complex with lack of adequate treatment with a very high health care spending. They have a huge tendency to get misdiagnosed or get wrongly diagnosed. Very few drug companies tend to invest into such rare diseases since it may be difficult to cover cost for developing therapeutics for such small and geographically diverse populations [7][8][9][10].

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Pediatric head and neck squamous cell carcinoma: Report of 12 cases and illustrated review of literature

Cited by 16 publications

References 28 publications

Fine-Needle Aspiration Cytology Is an Effective Diagnostic Tool in Paediatric Patients with Mucoepidermoid Carcinoma as Secondary Neoplasm

Fine-Needle Aspiration Cytology Is an Effective Diagnostic Tool in Paediatric Patients with Mucoepidermoid Carcinoma as Secondary Neoplasm

Unusual presentation of squamous cell carcinoma of the maxilla in an 8-year-old child

Understanding Systematic Reviews for Orphan Cancer Disorders-A Perspective

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