Oral squamous cell carcinoma in patients with and without predisposing habits in glossal and extra-glossal site: An institutional experience in South India

Ranganathan, Kannan; Thavarajah, Rooban; Rao, UK

doi:10.4103/0019-509x.178444

Cited by 19 publications

(14 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several risk factors have been identified as key players in the development and progression of OSCC such as tobacco smoking [7], smokeless tobacco [13] alcohol [14], betel quid [15] and areca nut chewing [16] and HPV infection [17]. Additionally, an equally common use of risk factors has been observed in both genders in Pakistan.…”

Section: Ivyspring International Publishermentioning

confidence: 99%

Overexpression of EGFR in Oral Premalignant Lesions and OSCC and Its Impact on Survival and Recurrence

Mirza¹,

Ali²,

Awan³

et al. 2018

Oncomedicine

View full text Add to dashboard Cite

Introduction: Oral squamous cell carcinoma (OSCC) the sixth leading cancer worldwide ranks as the most common cancer in males, and the third most common in females in Pakistan. It is influenced by risk factors which are widely consumed in our population. The epidermal growth factor receptor (EGFR) is a tyrosine kinase receptor that is imperative for cell signalling, growth and differentiation. It is mutated and overexpressed in a variety of cancers, while in OSCC it has been linked to poor patient survival; premalignant to malignant transformation and recurrence. This study investigates the use of EGFR as a prognostic factor for OSCC. Materials and Methods: Premalignant (n=29) and OSCC (n=100) formalin-fixed paraffin-embedded tissues were retrieved from the surgical archives of Aga Khan University Hospital (AKUH). Immunohistochemistry for EGFR overexpression was performed using monoclonal antibody on both groups. EGFR expression was correlated with habits of risk factor consumption, clinicopathologic features and 5-year survival and recurrence. Results: 15/29 premalignant and 67/100 OSCC patients had overexpressed EGFR. The upper/lower lip had the highest EGFR positivity among all premalignant sites of lesion (p=0.041). In OSCC patients, those who had EGFR overexpression had worse 5-year survival (univariate: p=0.048, multivariate: p=0.056) and higher chances of recurrence (univariate: p=0.01, multivariate: p=0.004) as compared to EGFR negative patients. Conclusion: EGFR is a viable candidate for an OSCC prognostic marker since its overexpression leads to poor survival and markedly increases the chances of recurrence.

show abstract

Section: Ivyspring International Publishermentioning

confidence: 99%

Overexpression of EGFR in Oral Premalignant Lesions and OSCC and Its Impact on Survival and Recurrence

Mirza¹,

Ali²,

Awan³

et al. 2018

Oncomedicine

View full text Add to dashboard Cite

show abstract

“…several studies have reported surprising increase in the incidence of oral cancer in patients with no exposure of tobacco and alcohol. 9,10 In recent times, there has been an increasing trend of OSCC development in females and young adults. Factors affecting the development of the oral squamous cell carcinoma are tobacco use, alcohol consumption, low socio-economic status, poor hygiene, poor diet, viral infection like HPV, ill-fitting dentures, jagged teeth.…”

mentioning

confidence: 99%

Clinical profile of the patients with oral squamous cell carcinoma: a tertiary institutional study

Jyoti

Arti

Jamwal

et al. 2020

Int J Otorhinolaryngol Head Neck Surg

View full text Add to dashboard Cite

Background: Oral cancer consists of a group of neoplasms affecting any region of the oral cavity. This term is commonly used interchangeably with oral squamous cell carcinoma (OSCC), representing the most frequent of all oral neoplasms. Factors affecting the development of the oral squamous cell carcinoma are tobacco use, alcohol consumption, low socio-economic status, poor hygiene, poor diet, viral infection like HPV, ill-fitting dentures, jagged teeth.Methods: An institution based retrospective observational study was conducted in the department of ENT, GMC Jammu, including the records of the patients with oral squamous cell carcinoma admitted from June 2016 to July 2019. 80 patients of oral carcinoma were included in the study.Results: Male to female ratio was 5.1:1. Mean age of presentation was 49.2±4.1 with most of the cases presenting in the 6th decade. 27 (33.75%) patients had history of chewing tobacco alone, 17 (21%) had smoking with chewing tobacco and 10 (12.5 %) smoking with alcohol. 52% patients presented with growth of tongue (52%) followed by buccal mucosa (17.5%) and other sites. Histopathological grading of OSCC showed predominance of well differentiated cancer in 44 cases (55%).Conclusions: Cases of OSCC are increasing day by day in young generation due to increasing exposure to the risk habits which are easily accessible to them.

show abstract

“…In developing countries like India, where chewing practices are more common, oral cancer represents up to 40% of all cancer compared to just 4% in United Kingdom. A study from South India stated that 74.8% of all the OSCC cases had at least one predisposing habit, mainly chewing areca nut (Ranganathan et al, 2015). Many studies point out the combination of more than one habits as the cause of oral malignancy, the fact being explained as the presence of one risk factor (smoking) enhancing the effects of the second risk factor (chewing) and showing synergism in development of oral cancer or potentially malignant oral disorders (Kadashetti et al, 2015, Ho et al, 2007.…”

Section: Discussionmentioning

confidence: 99%

Is There any Effect of Addictions in Arsenic Induced Oral Carcinoma?

Pal¹,

Raychowdhury²,

Poddar³

et al. 2019

IJALSR

View full text Add to dashboard Cite

Background-The association of various addictions with oral squamous cell carcinoma (OSCC) has been well established. But it's any possible link with metal toxicity has not been studied in the context of this carcinoma. Aim-To correlate the variation in the effect of various addictions with arsenic toxicity in the development of OSCC in the study population. Settings and design-It is a case-control study. Ethical clearance was obtained from the institutional committee. A total of 104 oral malignant, 103 premalignant and 200 age and sex matched healthy individuals were selected for the study. The history of addictions of case and controls was collected from questionnaire. Methods and material-On proper consent of cases & controls, the hair samples were collected for arsenic estimation by flow injection hydride generation atomic absorption spectrometry and the peripheral venous blood samples were processed for human leukocyte culture followed by Giemsa staining for the detection of chromosomal abnormality. Statistical analysis used-Student t test, logistic regression by R software and correlation analysis by Graph Pad software. Results-Significant correlation was observed between arsenic toxicity & OSCC (p value = 2.18e-06 ***). Smoking tobacco (r value 0.5365) was more significant over chewing tobacco (r value 0.4804). 3% of malignant cases showed chromosomal break. Conclusion-Statistically significant correlation among arsenic, addictions & OSCC in this study may indicate an associative role between the two factors. However, the study could not define any correlation with cytogenetic damage.

show abstract

Oral squamous cell carcinoma in patients with and without predisposing habits in glossal and extra-glossal site: An institutional experience in South India

Cited by 19 publications

References 14 publications

Overexpression of EGFR in Oral Premalignant Lesions and OSCC and Its Impact on Survival and Recurrence

Overexpression of EGFR in Oral Premalignant Lesions and OSCC and Its Impact on Survival and Recurrence

Clinical profile of the patients with oral squamous cell carcinoma: a tertiary institutional study

Is There any Effect of Addictions in Arsenic Induced Oral Carcinoma?

Contact Info

Product

Resources

About