Oral Squamous Cell Carcinoma: Clinicopathological Features in Patients with and without Recurrence

Abstract

Aim: To compare the clinicopathological profile of oral squamous cell carcinoma (OSCC) in groups with and without recurrence. Methods: Records of all patients who underwent surgery for primary OSCC at a single institution during 1999 were identified. Patient demographics, lesion site, clinical and pathologic stage, pathologic grading, pattern of invasion, lymphocytic infiltrate, perineural invasion, and treatment and survival data were collected. Descriptive statistics were calculated for each variable and survival was calculated using Kaplan-Meier and Cox models. Patients were divided into 2 groups: with (n = 25) and without (n = 28) recurrence. Results: Tongue (p = 0.02) and poorly differentiated (p = 0.04) tumors were associated with recurrence. Kaplan-Meier and Cox models revealed tobacco use and the absence of lymphocytic infiltrate to be associated with the poorest survival in recurrent OSCC. Conclusion: The tumor site, tobacco use, and pathological features were involved in the recurrence of OSCC and should be taken into account for OSCC treatment and follow-up.

Histopathological grading systems and their relationship with clinical parameters in lower lip squamous cell carcinoma

“…Although there are only a few published studies, the potential of this system to indicate the presence of lymph node metastasis and to predict local recurrence and overall survival in patients with oropharyngeal, laryngeal, and oral cavity squamous cell carcinomas has been emphasized. 10,13,20,22,23 In the present study, a highly significant association was observed between the risk score of LLSCC and regional lymph node metastasis (P = 0.004) and clinical stage (P = 0.002). These findings are in agreement with those of de Matos et al 23 who observed a significant association between high-risk score and the presence of regional lymph node metastasis in 62 cases of tongue squamous cell carcinoma.…”

“…Camisasca et al 20 also observed lower rates of overall and cancer-specific survival in patients with OSCCs who presented a weak lymphocytic response. de Matos et al 23 reported a significant association between the presence of regional lymph node metastasis and a weak lymphocytic response and perineural invasion in squamous cell carcinomas of the tongue.…”

“…These observations, together with the results of studies on OSCCs, 10,13,20,22,23 highlight the need for further investigations to evaluate the predictive potential of the system proposed by Brandwein-Gensler et al 21 for local recurrence and overall survival in patients with LLSCCs.…”

“…10 Among the main histopathological grading systems for OSCC are those proposed by Bryne et al, 14 also known as the 'invasive front grading system', and the World Health Organization (WHO). 15 Although the results of investigations evaluating the usefulness of these histopathological grading systems are conflicting, [9][10][11][12][16][17][18][19][20] recent studies have highlighted the potential of the 'histological risk assessment' model developed by BrandweinGensler et al 21 to indicate the presence of lymph node metastasis and to predict local recurrence and overall survival of patients with OSCCs. 10,13,20,22,23 Despite these important findings, to the best of our knowledge, there have been no studies investigating the possible use of the histopathological grading system developed by Brandwein-Gensler et al 21 to determine the prognosis in LLSCCs (PubMed database).…”

Role of Platelet Counts in Prognostication of Head And Neck Squamous Cell Carcinoma.

“…had reported 5 year survival rate of oral squamous cell carcinoma to be 92% in patient without recurrence & 30% in patient of recurrence. 18 Post-operative tumor recurrence leads to high morbidity & mortality. 17 High platelet count & poor tumor differentiation, presence of vascular invasion, regional & distant metastasis are poor prognostic factors in patient of head & neck squamous cell carcinoma.…”