Oral Polypodium leucotomos extract decreases ultraviolet-induced damage of human skin

Middelkamp‐Hup, Maritza A.; Pathak, Madhu A.; Parrado, Concepción; Goukassian, David A.; Rius-Díaz, Francisca; Mihm, Martín C.; Fitzpatrick, Thomas B.; González, Salvador

doi:10.1016/j.jaad.2004.06.027

Cited by 133 publications

(121 citation statements)

References 49 publications

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“…The incidence of phototoxicity was demonstrated to decrease after oral PL administration in subjects receiving psoralen-UVA (PUVA) treatment [99], as well as in normal healthy subjects [100]. In another study, PL-treated keratinocytes and fibroblasts exposed to UV displayed significantly ameliorated membrane integrity, mitigated lipid peroxidation, increased elastin expression and inhibited MMP-1 expression [101].…”

Section: Some Notable Anti-oxidantsmentioning

confidence: 98%

Skin ageing and its treatment

Baumann¹

2007

The Journal of Pathology

500

454

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The effects of chronic sun exposure on skin are readily apparent when skin not typically exposed to the sun and skin regularly exposed to the sun are compared. While the sun is not the only aetiological factor in the dynamic process of skin ageing, it is the primary exogenous cause among several internal and environmental elements. Thus, photo-ageing, the main focus of this article, is a subset of extrinsic skin ageing. The influence of the sun in extrinsic skin ageing, as well as its role in potentially altering the normal course of intrinsic (also known as natural or cellular) ageing, is discussed. Telomeres, the specialized structures found at the ends of chromosomes, are believed to be integral to cellular ageing as well as in the development of cancer. The ageing process, both intrinsic and extrinsic, is also believed to be influenced by the formation of free radicals, also known as reactive oxygen species. The loss of collagen is considered the characteristic histological finding in aged skin. Wrinkling and pigmentary changes are directly associated with photo-ageing and are considered its most salient cutaneous manifestations. Such photodamage represents the cutaneous signs of premature ageing. In addition, deleterious consequences of chronic sun exposure, specifically various forms of photo-induced skin cancer, are also linked to acute and chronic sun exposure. The only known strategies aimed at preventing photo-ageing include sun avoidance, using sunscreens to block or reduce skin exposure to UV radiation, using retinoids to inhibit collagenase synthesis and to promote collagen production, and using anti-oxidants, particularly in combination, to reduce and neutralize free radicals.

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Section: Some Notable Anti-oxidantsmentioning

confidence: 98%

Skin ageing and its treatment

Baumann¹

2007

The Journal of Pathology

500

454

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“…Moreover, oral administration of extracts of natural compounds such Polypodium leucotomos (PL) had been reported to induce photoprotective mechanisms through reduction of UV-induced reactive oxygen species and formation of free radicals, which in turn reduces post-UV inflammation, photodamage, and phototoxicity. 5,15 The mouse homologue of the human gene xeroderma pigmentosum group C (Xpc) has been cloned, and subsequently, knockout and heterozygote mice have been generated. 16 The Xpc heterozygote mice display a skin cancer proneness that is highly comparable with that observed in mild human XP syndromes, which may also model age-associated increase in skin cancer predisposition due to decline in DNA repair capacity, 17 as well as exaggerated inflammation secondary to UV exposure.…”

mentioning

confidence: 99%

Polypodium leucotomos Extract Decreases UV-Induced Cox-2 Expression and Inflammation, Enhances DNA Repair, and Decreases Mutagenesis in Hairless Mice

Zattra

Coleman

Arad

et al. 2009

The American Journal of Pathology

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mice were fed for 10 days with PL (300 mg/kg) or vehicle then UV-irradiated, once. By 24 hours, UVinduced Cox-2 levels were increased in vehicle-fed and PL-fed mice, whereas by 48 and 72 hours, Cox-2 levels were four-to fivefold lower in PL-fed mice (P < 0.05). p53 expression/activity was increased in PL-fed versus vehicle-fed then UV-irradiated mice. UV-induced inflammation was decreased in PL-fed mice, as shown by ϳ60% decrease (P < 0.001) in neutrophil infiltration at 24 hours, and macrophages by ϳ50% (<0.02) at 24 and 48 hours. By 72 hours, 54 ؎ 5% cyclobutane pyrimidine dimers remained in vehiclefed versus 31 ؎ 5% in PL-fed skin (P < 0.003). The number of 8-hydroxy-2-deoxyguanosine-positive cells were decreased before UV irradiation by ϳ36% (P < 0.01), suggesting that PL reduces constitutive oxidative DNA damage. By 6 and 24 hours, the number of 8-hydroxy-2-deoxyguanosine-positive cells were ϳ59% (P < 0.01) and ϳ79% (P < 0.03) lower in PL-fed versus vehicle-fed mice. Finally, UV-induced mutations in PL-fed-mice were decreased by ϳ25% when assessed 2 weeks after the single UV exposure. These data demonstrate that PL extract supplementation affords the following photoprotective effects: p53 activation and reduction of acute inflammation via Cox-2 enzyme inhibition, increased cyclobutane pyrimidine dimer removal, and reduction of oxidative DNA damage.

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“…* Polypodium leucotomos extract (PL) can also be administered orally with very low toxicity, in addition to its topical use as already described.Oral PL scavenges free radicals and reactive oxygen species such as superoxide anion, singlet oxygen, hydroxyl radical and hydrogen peroxide, and prevents lipid peroxidation [47,48]. Besides the effects already mentioned, PL also prevents oxidative DNA damage (8-hydroxyguanine) and accelerates repair of thymine dimers [24,49]. In addition, it also inhibitstrans-urocanic acid photo-induced isomerization and inactivation, as well as UVA-induced cyclobutane pyrimidine dimer deletions and mitochondrial DNA damage [50,51].…”

Section: Systemic Sunscreensmentioning

confidence: 96%

“…It is a potent antioxidant and has shown immunemodulating capability and inhibition of pro-inflammatory cytokines, such as TNF-α or IL-6 [22]. PL also inhibits the depletion of langerhan cells induced by irradiation with UV light and PUVA therapy [22][23][24] and reduces chronic elastosis and matrix metalloprotease expression [25,26]. * Dihydroxy-acetone: Photo-protective agent that provides SPF 3-4 and protects against UVA photons [27].…”

Section: Antioxidantsmentioning

confidence: 99%

Sunscreens and Antioxidants as Photo-protective Measures: An update

Hassan¹,

Dorjay²,

Sami³

et al. 2013

Our Dermatol Online

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There are many photo-protective measures adopted for protection from the solar radiation especially the UV radiation spectrum, sunscreens being the main agents. Besides the traditional approach of topical use of sunscreens, both chemical and physical, a new approach has emerged to use systemic agents in the form of vitamins and minerals. In this review, we are describing the major aspects related to sunscreens and anti-oxidants as photo-protective measures.

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Oral Polypodium leucotomos extract decreases ultraviolet-induced damage of human skin

Cited by 133 publications

References 49 publications

Skin ageing and its treatment

Skin ageing and its treatment

Polypodium leucotomos Extract Decreases UV-Induced Cox-2 Expression and Inflammation, Enhances DNA Repair, and Decreases Mutagenesis in Hairless Mice

Sunscreens and Antioxidants as Photo-protective Measures: An update

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