Oral peppermint oil is a useful antispasmodic for double‐contrast barium meal examination

Mizuno, Shigeaki; Kato, Kimitoshi; Yano, Kazunari; Kurosaka, Hanzo; Takahashi, Atsuhiko; Abeta, Hiromi; Kushiro, Toshio; Miyamoto, Shinobu; Kurihara, Ryo; Hiki, Naoki; Kaminishi, Michio; Iwasaki, Atsushi; Arakawa, Yasuyuki

doi:10.1111/j.1440-1746.2006.04131.x

Cited by 29 publications

(23 citation statements)

References 23 publications

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“…In addition, there is also evidence indicating that PMO decreases small bowel contractility and attenuates orocecal transit. Both duodenally instilled and given orally PMO decreased duodenal contractions in a double contrast barium study and manometry ( 37 – 39 ). Furthermore, a study using hydrogen breath testing showed that the PMO combination with caraway oil had delayed orocecal transit in healthy volunteers ( 40 ).…”

Section: Resultsmentioning

confidence: 99%

“…Another study using esophageal manometry demonstrated that PMO did not affect the esophageal body and LES pressures in patients with diffuse esophageal spasm despite improvement of manometric findings (46). Given orally or topically sprayed PMO also decreased spasm of the sto mach (37,47). Some studies using manometry and/or barostat have demonstrated various effects on the gastric physiology such as decreased intragastric pressure, decreased gastric motility index, with no change in gastric accommodation (38,39,48).…”

Section: Effects On Esophageal and Gastric Functionmentioning

confidence: 99%

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Herbal Therapies in Functional Gastrointestinal Disorders: A Narrative Review and Clinical Implication

Kim

Na-yeon

et al. 2020

Front. Psychiatry

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The pathophysiology of functional gastrointestinal disorders (FGIDs) is still unclear and various complex mechanisms have been suggested to be involved. In many cases, improvement of symptoms and quality of life (QoL) in patients with FGIDs is difficult to achieve with the single-targeted treatments alone and clinical application of these treatments can be challenging owing to the side effects. Herbal preparations as complementary and alternative medicine can control multiple treatment targets of FGIDs simultaneously and relatively safely. To date, many herbal ingredients and combination preparations have been proposed across different countries and together with a variety of traditional medicine. Among the herbal therapies that are comparatively considered to have an evidence base are iberogast (STW-5) and peppermint oil, which have been mainly studied and used in Europe, and rikkunshito and motilitone (DA-9701), which are extracted from natural substances in traditional medicine, are the focus of this review. These herbal medications have multi-target pharmacology similar to the etiology of FGIDs, such as altered intestinal sensory and motor function, inflammation, neurohormonal abnormality, and have displayed comparable efficacy and safety in controlled trials. To achieve the treatment goal of refractory FGIDs, extensive and high quality studies on the pharmacological mechanisms and clinical effects of these herbal medications as well as efforts to develop new promising herbal compounds are required.

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Section: Resultsmentioning

confidence: 99%

Section: Effects On Esophageal and Gastric Functionmentioning

confidence: 99%

Herbal Therapies in Functional Gastrointestinal Disorders: A Narrative Review and Clinical Implication

Kim

Na-yeon

et al. 2020

Front. Psychiatry

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“…To the best of our knowledge, this is the first report directly demonstrating an effect of a plant essential oil on isolated tissue preparations of rumen and abomasums in sheep. The Mentha species have been reported to reduce gastrointestinal motility in vivo (32), as well as to inhibit the spontaneous and agonist-induced contractions in gastrointestinal isolated segments in vitro (33). M. longifolia crude ethanol extract was effective on intestinal motility (34).…”

Section: Discussionmentioning

confidence: 99%

“…It was found that peppermint oil produces inhibition of spontaneous peristaltic activity and reduces total gastrointestinal transit or gastric emptying. The application of the peppermint oil further decreases the basal tone in the gastrointestinal tract, reduces the slow wave frequency in the esophagus and small intestine, which slows peristaltic movements and inhibits potassium depolarization-induced responses in the intestine (32).…”

Section: Discussionmentioning

confidence: 99%

Effects ofMentha longifoliaessential oil on ruminal and abomasal longitudinal smooth muscle in sheep

Jalilzadeh-Amin

Maham

Dalir‐Naghadeh

et al. 2012

Journal of Essential Oil Research

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Mentha longifolia is grown commercially for production of oils and leaves. For centuries, this plant has widely been used traditionally as a folk remedy for treatment of human and ruminant gastrointestinal complaints in the Northwest of Iran. The essential oil of the plant was extracted using hydrodistillation. In the present study a total of 12 constituents, representing 96.6% of the oil were identified by gas chromatography/mass spectrometry (GC/MS). The main compounds were 1,8-cineole (19.8%), pulegone (17.3%), caryophyllene oxide (14.8%) and isomenthone (12.4%). The effects of 0.1 to 1000 g/mL essence of Mentha longofolia (EOML) on ruminal and abomasal smooth muscle of 24 healthy sheep were assessed in vitro. In the isolated ruminal and abomasal preparations, EOML (0.1-100 g/mL) exhibited a weak spasmogenic effect followed by relaxation and complete (p < 0.05) abolition of the spontaneous contraction at the highest dose (1000 g/mL). In contrast rat ileum only showed a dose-dependent relaxation effect, and tissues preincubated with EOML decreased the acetylcholine (ACh) induced contraction. EOML (1000 g/mL) significantly inhibited the effect of ACh suggesting that the effect may be mediated via cholinergic receptors on smooth muscle. These primary data indicated that the plant contained spasmogenic and spasmolitic constituents. Moreover the results showed that the EOML profoundly alters gastrointestinal smooth muscle contraction in a dosedependent and tissue-specific manner. The results suggested that EOML has the potential for development as a prokinetic and relaxant agent that may prevent or alleviate dysfunctions of gastrointestinal motility.

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“…In nine studies, 269 healthy subjects or patients underwent exposure to peppermint either by topical intraluminal (stomach or colon) or oral administration. It was found that peppermint produces an inhibition of spontaneous peristaltic activity, reduces total gastrointestinal transit or gastric emptying, decreases the basal tone in the gastrointestinal tract, reduces the slow wave frequency in the esophagi, small intestine, which slows peristaltic movements, and inhibits potassium depolarization-induced responses in the intestine (Mizuno et al, 2006). It was observed that peppermint relaxed the lower esophageal sphincter, and that it was useful as an antispasmodic agent for double-contrast barium meal examination and in patients with dyspepsia (Melzer et al, 2004).…”

Section: Peppermint (Mentha Piperita)mentioning

confidence: 99%

Risks and benefits of commonly used herbal medicines in Mexico

Rodríguez‐Fragoso

Reyes‐Esparza

Burchiel

et al. 2008

Toxicology and Applied Pharmacology

152

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In Mexico, local empirical knowledge about medicinal properties of plants is the basis for their use as home remedies. It is generally accepted by many people in Mexico and elsewhere in the world that beneficial medicinal effects can be obtained by ingesting plant products. In this review, we focus on the potential pharmacologic bases for herbal plant efficacy, but we also raise concerns about the safety of these agents, which have not been fully assessed. Although numerous randomized clinical trials of herbal medicines have been published and systematic reviews and meta-analyses of these studies are available, generalizations about the efficacy and safety of herbal medicines are clearly not possible. Recent publications have also highlighted the unintended consequences of herbal product use, including morbidity and mortality. It has been found that many phytochemicals have pharmacokinetic or pharmacodynamic interactions with drugs. The present review is limited to some herbal medicine that are native or cultivated in Mexico and that have significant use. We discuss the cultural uses, phytochemistry, pharmacological and toxicological properties of the following following plant species: Nopal (Opuntia ficus), Peppermint (Mentha piperita), Chaparral (Larrea divaricata), Dandlion (Taraxacum officinale), Mullein (Verbascum densiflorum), Chamomile (Matricaria recutita), Nettle or Stinging Nettle (Urtica dioica), Passionflower (Passiflora incarmata), Linden Flower (Tilia europea), and Aloa (Aloa vera). We conclude that our knowledge of the therapeutic benefits and risks of some herbal medicines used in Mexico is still limited and efforts to elucidate them should be intensified.

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Oral peppermint oil is a useful antispasmodic for double‐contrast barium meal examination

Abstract: Oral PO is a safe, easy to use and effective antispasmodic for DCBM.

Cited by 29 publications

References 23 publications

Herbal Therapies in Functional Gastrointestinal Disorders: A Narrative Review and Clinical Implication

Herbal Therapies in Functional Gastrointestinal Disorders: A Narrative Review and Clinical Implication

Effects ofMentha longifoliaessential oil on ruminal and abomasal longitudinal smooth muscle in sheep

Risks and benefits of commonly used herbal medicines in Mexico

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