Oral pathoses as diagnostic indicators in leukemia

Stafford, R. E.; Sonis, Stephen T.; Lockhart, Peter B.; Sonis, Andrew L.

doi:10.1016/0030-4220(80)90200-5

Cited by 76 publications

(66 citation statements)

References 11 publications

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“…Dentists are responsible for initiating the diagnosis of leukemia in a significant number of acute nonlymphoblastic patients with leukemia since oral lesions are among the common signs or symptoms in undiagnosed patients with acute leukemia (4).…”

Section: Introductionmentioning

confidence: 99%

Leukemia and its Oral Manifestations in Children Younger than 12 Years Referred to Tehran Pediatric Hospitals

Nakhostin¹,

Meighani²

2016

Avicenna J Dent Res

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Background: Acute leukemia is a malignant, rapidly progressive disease of the bone marrow and blood that most commonly occurs in children. Abnormalities of blood caused by leukemia and also accumulation of leukemic cells in different parts of the oral cavity cause a wide spectrum of oral manifestations. Objectives: The current study aimed to estimate the incidence of leukemia among children in Tehran and evaluate oral manifestations of the disease as potential diagnostic markers. Patients and Methods: In this retrospective cross-sectional study, medical records of children younger than 12 years referred to Mofid hospital, Ali-Asghar hospital and Children's medical center from 1997to 2011 were retrieved from the hospital archives and evaluated. Records of 100 patients with leukemia were randomly selected for evaluation. The obtained data were transferred to the questionnaires. Data were analyzed using SPSS version 11.5 and Chi-square test. Results: Of the 3,789 children younger than 12 years referred to the hematology department of Tehran pediatric hospitals from 1997 to 2001, 1,372 had acute leukemia, put of which 94% had acute lymphoblastic leukemia and 5% had acute myeloid leukemia. Boys aged 5 -10 years made up 69% of the acute leukemia cases. The most common oral manifestation was gingival bleeding and petechiae. The most important disease other than leukemia was anemia in the patients. Conclusions:The present study highlights the role of dentists to detect oral manifestations of leukemia and their possible role in early diagnosis of patients with the disease.

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Section: Introductionmentioning

confidence: 99%

Leukemia and its Oral Manifestations in Children Younger than 12 Years Referred to Tehran Pediatric Hospitals

Nakhostin¹,

Meighani²

2016

Avicenna J Dent Res

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“…This type of leukemia, in general, is only third in frequency and, due to its chronic nature, often presents no symptoms and is associated with the absence of oral manifestations. 4,5,7,13,14,16,18 However, this is understandable in view of the study's eligibility criteria (patients 14 and older), since CML usually occurs in adults.…”

Section: (324)mentioning

confidence: 90%

“…Specifically regarding thrombocytopenia (low platelet count), an association between increased risk of bleeding and occurrence of hemorrhagic episodes in leukemic patients has been suggested. [13][14][15][16][17][18][20][21][22] While there is no consensus in the literature about the most prevalent oral manifestations in leukemic patients, gingival bleeding, gingival swelling, ulcers and petechiae are the most frequently reported. 1,4,5,[8][9][10][11][12]16,17,19 In patients undergoing active treatment for leukemia, gingival bleeding and petechiae were the most common findings in the oral cavity, occurring twice as often in patients having the acute form of leukemia.…”

Section: Discussionmentioning

confidence: 99%

“…7,13,14,18 These data are often collected by nondental health professionals, who do not provide adequate information about the periodontal status of this group of patients. A limited number of studies [20][21][22] have reported the prevalence of periodontal parameters in these individuals, and then only in patients with the acute form of the disease.…”

Section: Introductionmentioning

confidence: 99%

“…In this sense, thrombocytopenia is considered an important secondary effect of the disease and a potential risk factor. [3][4][5] Oral manifestations (gingival swelling [7][8][9][10][11][12] and gingival and oral bleeding [13][14][15][16][17][18] ) have been associated with leukemia. Gingival swelling is the most common oral sign in untreated patients.…”

Section: Introductionmentioning

confidence: 99%

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Gingival inflammation and platelet count in patients with leukemia: preliminary results

et al. 2011

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Leukemia has been associated with oral manifestations. However, the available literature on this topic consists of mostly reports of cases, without data about the periodontal parameters that may be under the influence of hematologic factors. The aim of this cross-sectional study was to assess the correlation between the Gingival Index and Bleeding on Probing with the platelet count in patients with leukemia. Patients with diagnosis of any kind of leukemia, at any stage of treatment, having a minimum age of 14 years, treated at the Department of Hematology-Oncology of the University Hospital of Santa Maria, Brazil, between December 2009 and March 2010, were assessed. Excluded patients were: edentulous, with orthodontic appliances, with psychomotor disturbances, requiring antibiotic prophylaxis for the examinations, or those using medications associated with gingival swelling. Two trained and calibrated examiners evaluated the Plaque Index, Gingival Index (GI), Probing depth, Bleeding on Probing (BOP), and Clinical Attachment Loss. Hematologic data were collected from a blood test performed on the same day as the periodontal examination. Thirty-seven patients (26 males), aged between 15 and 80 years (mean age 41.7 ± 18.31) were evaluated. Correlation between platelet count and BOP (p > 0.05), or between platelet count and GI (p > 0.05), were both weak (Pearson's correlation coefficient r = 0.171 and r = −0.003, respectively) and not statistically significant. It can be concluded from the preliminary results that the low platelet count was not correlated with the higher prevalence of gingival and periodontal bleeding in patients with leukemia.

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Case of pediatric acute promyelocytic leukemia presenting as extramedullary tumor of the mandible

Yamashita¹,

Isomura²,

Hamasaki³

et al. 2012

Head & Neck

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Oral pathoses as diagnostic indicators in leukemia

Cited by 76 publications

References 11 publications

Leukemia and its Oral Manifestations in Children Younger than 12 Years Referred to Tehran Pediatric Hospitals

Leukemia and its Oral Manifestations in Children Younger than 12 Years Referred to Tehran Pediatric Hospitals

Gingival inflammation and platelet count in patients with leukemia: preliminary results

Case of pediatric acute promyelocytic leukemia presenting as extramedullary tumor of the mandible

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