Oral passive immunization against experimental salmonellosis in mice using chicken egg yolk antibodies specific for Salmonella enteritidis and S. typhimurium

Avian Antibodies (IgY) to Fight Antibiotic Resistance

“…Salmonella species: The passive protective efficacy of avian IgY to control experimental salmonellosis in mice [15] and calves [16] has been examined. The animals treated with specific IgY showed increased survival.…”

Animal Feed Production and Contamination by Foodborne Salmonella

“…There is a clear need for either generation of antibodies that are resistant to these conditions or development of another means for delivery of biologically active antibodies in the gastrointestinal system. Specifi c antibodies contained in crude egg yolk preparations have been shown to be more resistant to gastric acid pH and proteases than purifi ed sources in vitro (Lösch et al, 1986;Schmidt et al, 1989) and in vivo oral administration of egg yolk antibodies has been successfully used for the prevention of salmonellosis infections in mice (Peralta et al, 1994;Yokoyama et al 1998a) and calves (Yokoyama et al, 1998b). However, production of large quantities of specifi c antibodies still requires intensive animal management and antibody harvesting logistics which may preclude routine use of such sources.…”

Extracellular Antigens fromSalmonella enteritidisInduce Effective Immune Response in Mice after Oral Vaccination

“…The important role of antibody-producing B cells in protection against salmonellosis has been shown by Mastroeni et al (28). Moreover, Yokoyama et al (43) showed that egg yolk antibodies specific for Salmonella flagellin, LPS, and outer membrane proteins such as porin protect mice from salmonellosis when administered orally. This is in line with our study, in which we have shown that oral administration of secreted proteins primarily gives antibodies against flagellin.…”