Oral manifestations of leukemia in children

White, G. Edward

doi:10.1016/0030-4220(70)90144-1

Cited by 24 publications

(9 citation statements)

References 9 publications

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“…To our knowledge, this is the first time, that leukemic gingival infiltration is reported in this type of AL. Of the cases with no clinical evidence of gingival enlargement seen, cytological examination yielded four with definitive gingival infiltration; this agrees with the finding of White (17), as he found leukemic infiltration in autopsy material of gingival tissues in a child with ALL and no gingival enlargement.…”

Section: Discussionsupporting

confidence: 86%

Gingival fine needle aspiration cytology in acute leukemia

Abdullah¹,

Yahya²,

Kummoona³

et al. 2002

J Oral Pathology Medicine

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Section: Discussionsupporting

confidence: 86%

Gingival fine needle aspiration cytology in acute leukemia

Abdullah¹,

Yahya²,

Kummoona³

et al. 2002

J Oral Pathology Medicine

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“…This is in agreement with the finding of White[8] who reported leukemic infiltration in autopsy material of gingival tissue in a child with ALL with no gingival enlargement. Similarly, in the study done by Abdullah et al .,[1] of the cases with no clinical evidence of gingival enlargement seen, cytological examination showed four cases with definitive gingival infiltration.…”

Section: Discussionsupporting

confidence: 93%

A clinical and fine needle aspiration cytology study of gingiva in acute leukemia

Arul¹,

Verma²,

Ahmed³

et al. 2012

Dent Res J

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Background:Oral manifestations are frequently the initial signs of acute leukemia, prompting the patient to consult the dentist first. The gingival tissue is one site commonly involved either by leukemic infiltration or by inflammatory reactive hyperplasia, causing gingival enlargement. The gingival infiltration may also be present without gingival enlargement. Early recognition of clinical findings in the oral cavity leads to its timely diagnosis and management. Since biopsy is highly contraindicated, gingival fine needle aspiration cytology was performed to assess its diagnostic value in detecting gingival infiltration in acute leukemia patients.Materials and Methods:Fifty patients of acute leukemia received clinical and gingival cytological examination. The cases were diagnosed based on bone marrow aspiration findings and classified according to the French–American–British criteria. The absence or presence of intraoral findings was recorded. Site for gingival fine needle aspiration cytology was selected.Results:Leukemic gingival infiltration was found to be more common in acute lymphoblastic leukemia, while the characteristic oral findings were seen more commonly in acute myeloblastic leukemia. All the eight cases of acute lymphoblastic leukemia that were positive for leukemic gingival infiltration showed no clinical evidence of gingival enlargement. In terms of leukemic gingival infiltration, L2 subtype was the only subtype involved, while M5 was more commonly involved than M4 subtype. Two cases of L2 subtype showed gingival enlargement due to local factors like plaque/calculus rather than due to leukemic infiltration.Conclusion:The technique was found to be safe and of definitive diagnostic value in detecting gingival infiltration in acute leukemia patients.

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“…Both induction phase and Intensification phase involve intense course of chemotherapeutic agents and are associated with a higher incidence of immunosuppression and concomitant infections in comparison to Maintenance phase of therapy . The oral manifestations seen in ALL differ according to the phase of therapy and are related to the intensity of chemotherapeutic agents used and immune status of the individual …”

Section: Introductionmentioning

confidence: 99%

“…The oral manifestations also tend to be type specific and may present as the only initial manifestation of the disease . The primary complications occur due to leukemic infiltration in the oral structures presenting as leukemic gingival enlargement.…”

Section: Introductionmentioning

confidence: 99%

“…9 The oral manifestations seen in ALL differ according to the phase of therapy and are related to the intensity of chemotherapeutic agents used and immune status of the individual. 8,10 The oral manifestations also tend to be type specific and may present as the only initial manifestation of the disease. 10 The primary complications occur due to leukemic infiltration in the oral structures presenting as leukemic gingival enlargement.…”

mentioning

confidence: 99%

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Assessment of oral health status of children with Leukemia: A cross‐sectional study

Kapoor

Goswami

Sharma

et al. 2019

Special Care in Dentistry

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Aim The present study was conducted with an aim to assess the oral hygiene status, gingival health status, and prevalence of dental caries, oral mucositis and xerostomia among children with leukemia and compare it with healthy children. Methods and Results A total sample size of 220 children with 110 children with Leukemia of subtype acute lymphoblastic leukemia (ALL) undergoing treatment and 110 healthy children in the age group of 3‐14 years was selected. Evaluation of caries status using dmft/DMFT indices, oral hygiene status using OHI‐S and plaque index by Sillness and Loe, gingival health status using modified gingival index, oral mucositis as per WHO oral toxicity scale, xerostomia as per common terminology criteria for adverse events for dry mouth, and salivary pH using pH paper strips was done. Results revealed a lower prevalence of dental caries, good oral hygiene and mild gingivitis in children with ALL when compared to healthy children. Oral mucositis was found to occur only in children with ALL and a reduced salivary flow rate and reduced salivary pH were seen in these children when compared to healthy children. Conclusion It was concluded that children with ALL undergoing treatment and following an oral care protocol presented with a good Oral Health Status when compared with healthy children.

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Oral manifestations of leukemia in children

Cited by 24 publications

References 9 publications

Gingival fine needle aspiration cytology in acute leukemia

Gingival fine needle aspiration cytology in acute leukemia

A clinical and fine needle aspiration cytology study of gingiva in acute leukemia

Assessment of oral health status of children with Leukemia: A cross‐sectional study

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