Oral lichenoid reactions associated with amalgam: improvement after amalgam removal

Dunsche, Anton; Kästel, I.; Terheyden, Hendrik; Springer, Ingo N.; Christophers, Enno; Brasch, Jochen

doi:10.1046/j.1365-2133.2003.04936.x

Cited by 116 publications

(120 citation statements)

References 25 publications

(45 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Dunsche described a regression in the manifestation of lichenoid changes after amalgam substitution in 97 % of 134 patients, independent of results of epicutaneous testing 20 . He also experimentally confi rmed the possible locally toxic eff ect of amalgam and the significance between a close topographical relationship between artifi cial material and pathological manifestation on the mucosa 21 .…”

mentioning

confidence: 99%

Oral Lichenoid Lesions and Allergy to Dental Materials

Ditrichová¹,

Kaprálová²,

Tichý³

et al. 2007

BIOMED PAP

View full text Add to dashboard Cite

Background: Dental materials, oral hygiene products and food additives may cause contact allergic reactions in the mouth with varied clinical presentation. Oral lichenoid lesions (lichen planus-like lesions) can be induced by hypersensitivity to dental restorative metals, acrylates, fl avorings and other substances.Aim: The aim of this study was to demonstrate contact allergy to dental materials in patients with oral lichenoid lesions using patch tests.Patients and methods: Routine patch tests with two sets of allergens -"European Standard" and "Dental Screening" (Chemotechnique Diagnostics, Sweden) supplemented with pulverized amalgam, iridium, indium, menthol, sorbic acid and platinum were done on a set of 25 patients with lichenoid lesions located on the buccal mucosa, tongue and lips. Application and interpretation of the tests were conducted according to ICDRG (International Contact Dermatitis Research Group).Results: 15 (60 %) patients showed sensitization to 1 or more allergens, with a total of 31 positive reactions. The greatest frequency of positive reactions was to dental metals, with a total of 27 positive reactions. The order of tested metals according to frequency of positive reactions was mercury (6/25/24 %), amalgam (6/25/24 %), nickel (4/25/16 %), palladium (4/25/16 %), cobalt (3/25/12 %), gold (2/25/8 %), chrome (1/25/4 %), indium (1/25/4 %). The clinical relevance of the results with regard to the material's presence in the mouth was demonstrated in 11 (44 %) patients. In 9 patients, replacement of the positively tested materials led to healing or to signifi cant regression of mucosal changes. Conclusions:The results of the patch tests showed the possible contribution of contact sensitization in the pathogenesis of lichenoid manifestations in the oral cavity. Due to the premalignant character of these lesions, replacement of positively tested materials and follow up of these patients is advised.

show abstract

mentioning

confidence: 99%

Oral Lichenoid Lesions and Allergy to Dental Materials

Ditrichová¹,

Kaprálová²,

Tichý³

et al. 2007

BIOMED PAP

View full text Add to dashboard Cite

show abstract

“…OLRs caused by amalgam restorations can be found in the literature, with symptoms such as eczema, urticaria, wheals on the face and limbs, rashes and sometimes pink or Kawasaki disease [2,12,23]. In several cases, systemic reactions have been noted [24].…”

Section: Discussionmentioning

confidence: 99%

“…OLRs are often seen in direct topographic relation to the offending agent and are generally unilateral, and they can be reticular, in the form of plaques, atrophic and erosive or a combination of the foregoing. However, classical OLP presents as bilateral and symmetrical, white, papular/reticular or red atrophic/ulcerative lesions affecting all areas of the oral mucosa [12][13][14]. The possible etiologic factors of OLP include genetic background, infectious agents, autoimmune reactions, immunodeficiency, chronic liver disease, drugs, chemicals, stress, trauma, food allergies, diabetes, hypertension, malignant neoplasms, electrogalvanism and dental materials [15,16].…”

Section: Introductionmentioning

confidence: 99%

“…The symptoms are normally classified as delayed hypersensitivity reactions (type IV), and they were called oral lichenoid reactions (OLRs) by Finne et al [8]. OLRs affect oral mucosa in direct contact with amalgam restorations, and they represent a delayed, type IV, cell-mediated immune response to mercury or many metals, such as gold, palladium, nickel, chrome, and cobalt, may induce OLRs [8,9], and but the material most frequently associated with OLRs is dental amalgam, and the lesions are the consequence of a hypersensitivity to one of its components, often mercury, but sometimes copper, zinc, or tin [8][9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Oral lichenoid contact lesion to amalgam restoration: a case report

Uzun¹,

Özyürek²,

Günduz³

2014

Oral Biol Dent

View full text Add to dashboard Cite

“…Dentro de estos materiales cabe destacar la especial participación de la amalgama de plata, que con frecuencia se asocia a la aparición de lesiones blanquecinas reticulares con aspecto arboriforme (11)(12)(13)(14).…”

Section: Materiales Odontológicosunclassified

Liquen plano: Revisión de la literatura actual

Matesanz-Pérez¹,

Bascones-Martínez²

2009

Av Odontoestomatol

View full text Add to dashboard Cite

RESUMENObjetivo: Proporcionar información actualizada acerca del liquen plano oral, prestando atención especial a su posible malignización y a su relación con el cáncer oral. El liquen es una enfermedad mucocutánea con una relevancia particular en la cavidad oral, no sólo debida a su prevalencia, sino también debida al hecho de estar englobada dentro de los denominados "enfermedades o estados premalignos". La relación del liquen plano con el cáncer oral aumenta la necesidad de revisar la literatura, para así comprender cuánto puede hacer el clínico al respecto, y aprender cómo manejar esta patología.Palabras clave: Liquen plano oral; apoptosis; cáncer oral; tratamiento; inmunología; linfocitos. SUMMARY Aims:To provide updated knowledge about oral lichen planus, paying especial attention to its possible malignant transformation and the relationship with oral cancer. Oral lichen planus is a mucocutaneous disorder with particular relevance in the oral cavity, not only due to its prevalence, but due to the fact of belonging to the group of "premalignant lesions or states". The relationship that this pathology has with oral cancer increases the need for literature reviewing so as to learn what the practitioner can do about it and how to manage it.Key words: Oral lichen planus; apoptosis; oral cancer; treatment; immunology; lymphocytes. Liquen plano: Revisión de la literatura actual Oral lichen planus. A review of literatureMatesanz-Pérez P*, Bascones-Martínez, A** INTRODUCCIÓNEl liquen plano oral es un desorden del epitelio escamoso que cobra importancia por dos motivos principalmente: por un lado está su frecuente aparición en todo el mundo, especialmente en sujetos de edad media, con mayor incidencia en el sexo femenino (1). Por otro lado, el liquen plano debe ser estudiado con cuidado dado su potencial de malignización. A pesar de la permanente controversia entre las distintas fuentes a la hora de establecer las probabilidades de que el liquen oral sufra una transformación ma-

show abstract

Oral lichenoid reactions associated with amalgam: improvement after amalgam removal

Cited by 116 publications

References 25 publications

Oral Lichenoid Lesions and Allergy to Dental Materials

Oral Lichenoid Lesions and Allergy to Dental Materials

Oral lichenoid contact lesion to amalgam restoration: a case report

Liquen plano: Revisión de la literatura actual

Contact Info

Product

Resources

About