Oral Intake of Low-Molecular-Weight Collagen Peptide Improves Hydration, Elasticity, and Wrinkling in Human Skin: A Randomized, Double-Blind, Placebo-Controlled Study

Abstract

Collagen-peptide supplementation could be an effective remedy to improve hydration, elasticity, and wrinkling in human skin. The aim of this study was to conduct a double-blind, randomized, placebo-controlled trial to clinically evaluate the effect on human skin hydration, wrinkling, and elasticity of Low-molecular-weight Collagen peptide (LMWCP) with a tripetide (Gly-X-Y) content >15% including 3% Gly-Pro-Hyp. Individuals (n = 64) were randomly assigned to receive either placebo or 1000 mg of LMWCP once daily for 12 weeks. Parameters of skin hydration, wrinkling, and elasticity were assessed at baseline and after 6 weeks and 12 weeks. Compared with the placebo group, skin-hydration values were significantly higher in the LMWCP group after 6 weeks and 12 weeks. After 12 weeks in the LMWCP group, visual assessment score and three parameters of skin wrinkling were significantly improved compared with the placebo group. In case of skin elasticity, one parameter out of three was significantly improved in the LMWCP group from the baseline after 12 weeks, while, compared with the placebo group, two parameters out of three in the LMWCP group were higher with significance after 12 weeks. In terms of the safety of LMWCP, none of the subjects presented adverse symptoms related to the test material during the study period. These results suggest that LMWCP can be used as a health functional food ingredient to improve human skin hydration, elasticity, and wrinkling.

Biological activity of peptides purified from fish skin hydrolysates

“…The peptide downregulated the expression of MMP-3 and MMP-13, while it upregulated the expression of MMP-2 and MMP-9 (Pyun et al 2012). In the clinical trial results, treatment groups receiving a daily oral dosage of 1000 mg of LMWCP for 12 weeks showed significantly improved skin and less wrinkling in comparison with the placebo group (Kim et al 2018). Last but not least, fish skin has also been demonstrated to have adipogenic regulatory activity.…”

Collagen supplementation for skin health: A mechanistic systematic review

“…Further screening by title and/or abstract resulted in removal of 6500 items. Finally, full texts of the 31 remained items were assessed for eligibility and 10 publications were included in this review 2,3,12‐15,25‐28 . Table 1 shows the features of selected studies which assessed the effect of collagen (intact or hydrolyzed) supplementation on skin health or aging parameters.…”

Skin Aging & Modern Age Anti-aging Strategies

“…Oral administration of Low-molecular-weight Collagen peptide (LMWCP), which is a fish-derived collagen hydrolysate, promotes recovery of collagen fibers and normal elastic fibers in the skin from degraded collagen and abnormal elastic fibers caused by UVB irradiation in hairless mice [167]. Kim et.al, 2018 reported that LMWCP is a safe health functional food ingredient with anti-skin photoaging efficacy which can effectively improve hydration, elasticity, and wrinkling in human skin at the dose of 1000 mg once daily [168]. Figure 15: Collagen fiber structure, absorption/metabolism and deposition into skin cells and dermal layers.…”