Biological activity of peptides purified from fish skin hydrolysates

Abuine, Racheal; Rathnayake, Anuruddhika Udayangani; Byun, Hee‐Guk

doi:10.1186/s41240-019-0125-4

Cited by 87 publications

(59 citation statements)

References 107 publications

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“…Hydrolysates produced from skin gelatine of this fish inhibited several bacteria strains including three Gram-negative (Klebsiella pneumonia, Salmonella enterica, and Salmonella typhi) and three Gram-positive (M. luteus, Staphylococcus aureus, and B. cereus) bacteria [275]. Antimicrobial activity of protein hydrolysates and peptides generated from skins of other fish were also reported [276]. Protein hydrolysate prepared from viscera of Scorpaena notata using a purified serine protease (Th-Protease) exhibited remarkable antibacterial activities in vitro.…”

Section: Antimicrobialmentioning

confidence: 66%

Protein Recovery from Underutilised Marine Bioresources for Product Development with Nutraceutical and Pharmaceutical Bioactivities

2020

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The global demand for dietary proteins and protein-derived products are projected to dramatically increase which cannot be met using traditional protein sources. Seafood processing by-products (SPBs) and microalgae are promising resources that can fill the demand gap for proteins and protein derivatives. Globally, 32 million tonnes of SPBs are estimated to be produced annually which represents an inexpensive resource for protein recovery while technical advantages in microalgal biomass production would yield secure protein supplies with minimal competition for arable land and freshwater resources. Moreover, these biomaterials are a rich source of proteins with high nutritional quality while protein hydrolysates and biopeptides derived from these marine proteins possess several useful bioactivities for commercial applications in multiple industries. Efficient utilisation of these marine biomaterials for protein recovery would not only supplement global demand and save natural bioresources but would also successfully address the financial and environmental burdens of biowaste, paving the way for greener production and a circular economy. This comprehensive review analyses the potential of using SPBs and microalgae for protein recovery and production critically assessing the feasibility of current and emerging technologies used for the process development. Nutritional quality, functionalities, and bioactivities of the extracted proteins and derived products together with their potential applications for commercial product development are also systematically summarised and discussed.

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Section: Antimicrobialmentioning

confidence: 66%

Protein Recovery from Underutilised Marine Bioresources for Product Development with Nutraceutical and Pharmaceutical Bioactivities

2020

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“…In vivo studies in the mice showed that salmon skin collagen peptides reduced oxidative damage [110] and acetylcholinesterase (AChE) and increased phosphorylated cAMP-response element binding protein (p-CREB) and brain-derived neurotrophic factor (BDNF) expression [111]. Moreover, collagen from salmon skin was used with hydroxyapatite to produce scaffolds for bone regeneration, based on the biomimetic mineralization principle [112].…”

Section: Fish Wastementioning

confidence: 99%

“…Subcritical water-hydrolysed fish collagen peptide (SWFCP) from tuna skin shown adipogenic regulatory activity [110,113]. In particular, SWFCP downregulated the expression of key adipogenic target genes (C/EBP and PPAR protein) and transcription factors in 3T3-L1 preadipocytes exposed to dexamethasone and insulin.…”

Section: Fish Wastementioning

confidence: 99%

Marine Collagen from Alternative and Sustainable Sources: Extraction, Processing and Applications

et al. 2020

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Due to its unique properties, collagen is used in the growing fields of pharmaceutical and biomedical devices, as well as in the fields of nutraceuticals, cosmeceuticals, food and beverages. Collagen also represents a valid resource for bioplastics and biomaterials, to be used in the emerging health sectors. Recently, marine organisms have been considered as promising sources of collagen, because they do not harbor transmissible disease. In particular, fish biomass as well as by-catch organisms, such as undersized fish, jellyfish, sharks, starfish, and sponges, possess a very high collagen content. The use of discarded and underused biomass could contribute to the development of a sustainable process for collagen extraction, with a significantly reduced environmental impact. This addresses the European zero-waste strategy, which supports all three generally accepted goals of sustainability: sustainable economic well-being, environmental protection, and social well-being. A zero-waste strategy would use far fewer new raw materials and send no waste materials to landfills. In this review, we present an overview of the studies carried out on collagen obtained from by-catch organisms and fish wastes. Additionally, we discuss novel technologies based on thermoplastic processes that could be applied, likewise, as marine collagen treatment.2 of 23 protective colloid functions and film-forming capacity. Also, collagen is a good surface-active agent, with its ability to penetrate lipid-free interfaces [2].Collagen can be utilized in a variety of applications because of its biocompatibility and excellent degradability [3,4]. Furthermore, it is known that collagen is a molecule with weak immunogenicity, which decreases the possibilities of rejection when it is ingested or injected into a different body. Although this molecule has already low antigenicity, this property can be enhanced by modifying it to suppress any immune response [5,6]. Additionally, collagen peptides and gelatin (denatured collagen) have been widely utilized in different fields such as food, medicine, cosmetics, leather and film industries, diagnostic imaging, and therapeutic delivery [7].For many years, most available collagen was extracted from discards from the bovine and porcine processing industries, but during the last few decades the use of collagen from these sources has been limited. The use of porcine and bovine-derived products is occasionally prevented by dietary regimes, due to specific needs or personal choices. It is forbidden by religious constraints, to Muslims, Hindus and Jews who make up 38.4% of the global population [8]. Moreover, the use of bovine-derived products became a concern for a wider section of the population during the bovine spongiform encephalopathy (BSE), transmissible spongiform encephalopathy (TSE) and foot-and-mouth disease (FMD) crises that occurred over the last few decades in all areas of the world, mostly in the United Kingdom and Asia. Bovine-derived products might be a vehicle of transmission of these diseases ...

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“…Therefore, ROS, a hydroxyl radical, has been recognized as a DNA-damaging agent of physiological significance (You et al 2002). Bioactive peptides with various biological activities such as antioxidative activity can be utilized in order to develop pharmaceutical and nutraceutical products in industrial scale (Abuine et al 2019).…”

Section: Prevention Of Oxidation-induced Dna Damage By a Black Eelpoumentioning

confidence: 99%

Characterization of antioxidative peptide purified from black eelpout (Lycodes diapterus) hydrolysate

Lee

Byun

2019

Fish Aquatic Sci

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The functional peptides from protein hydrolysates of various fishery sources have been identified such as antioxidant activity. The main intention of this study was purification and characterization of antioxidative peptide from black eelpout muscle. The antioxidative peptides were purified from black eelpout (Lycodes diapterus) muscle using different proteases. Antioxidant activity of black eelpout hydrolysates was evaluated using DPPH radical scavenging activity. Among six hydrolysates, the pepsin hydrolysate had the highest antioxidant activity compared to the other hydrolysates. Therefore, it was further purified and a peptide with seven amino acid residues of DLVKVEA (784 Da) was identified by amino acid sequence analysis. The EC 50 value for scavenging DPPH radicals by purified peptide was 688.77 μM. Additionally, the purified peptide exhibited protective effect against DNA damage induces by oxidation in mouse macrophages (RAW 264.7 cells). The results of this study suggest that black eelpout muscle protein hydrolysate could potentially contribute to development of bioactive peptides in basic research.

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Biological activity of peptides purified from fish skin hydrolysates

Cited by 87 publications

References 107 publications

Protein Recovery from Underutilised Marine Bioresources for Product Development with Nutraceutical and Pharmaceutical Bioactivities

Protein Recovery from Underutilised Marine Bioresources for Product Development with Nutraceutical and Pharmaceutical Bioactivities

Marine Collagen from Alternative and Sustainable Sources: Extraction, Processing and Applications

Characterization of antioxidative peptide purified from black eelpout (Lycodes diapterus) hydrolysate

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