Oral intake of <i>Boesenbergia pandurata</i> extract improves skin hydration, gloss, and wrinkling: A randomized, double‐blind, and placebo‐controlled study

Kim, Do Un; Chung, Hee Chul; Kim, Chang-Hee; Hwang, Jae Kwan

doi:10.1111/jocd.12343

Cited by 21 publications

(13 citation statements)

References 27 publications

(31 reference statements)

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“…Skin aging is a degradative process with morphological and functional changes, such as elasticity, strength loss and hyperpigmentation. Intrinsic and extrinsic factors are the leading causes of these degradative changes [1]. Intrinsic factors can be defined as physiological changes regulated by inherited genes and the passing of time.…”

Section: Introductionmentioning

confidence: 99%

Black Bean (Phaseolus vulgaris L.) Polyphenolic Extract Exerts Antioxidant and Antiaging Potential

et al. 2021

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Phenolic compounds present in common beans (Phaseolus vulgaris L.) have been reported to possess antimicrobial, anti-inflammatory and ultraviolet radiation (UVR) protective properties. UVR from sunlight, which consists of UV-B and UV-A radiations, induces reactive oxygen species (ROS) and free radical formation, consequently activating proteinases and enzymes such as elastase and tyrosinase, leading to premature skin aging. The objective of this work was to extract, characterize and evaluate the antioxidant and antiaging potential of polyphenols from a black bean endemic variety. The polyphenolic extract was obtained from black beans by supercritical fluid extraction (SFE) using CO2 with a mixture of water–ethanol as a cosolvent and conventional leaching with a mixture of water–ethanol as solvent. The polyphenolic extracts were purified and characterized, and antioxidant potential, tyrosinase and elastase inhibitory potentials were measured. The extract obtained using the SFE method using CO2 and H2O–Ethanol (50:50 v/v) as a cosolvent showed the highest total phenolic compounds yield, with 66.60 ± 7.41 mg GAE/g coat (p > 0.05) and 7.30 ± 0.64 mg C3GE/g coat (p < 0.05) of anthocyanins compared to conventional leaching. Nineteen tentative phenolic compounds were identified in leaching crude extract using ESI-QTOF. Quercetin-3-D-galactoside was identified in crude and purified extracts. The purified SFC extract showed IC50 0.05 ± 0.002 and IC50 0.21 ± 0.008 mg/mL for DPPH and ABTS, respectively. The lowest IC50 value of tyrosinase inhibition was 0.143 ± 0.02 mg/mL and 0.005 ± 0.003 mg/mL of elastase inhibition for leaching purified extract. Phenolic compounds presented theoretical free energy values ranging from −5.3 to −7.8 kcal/mol for tyrosinase and −2.5 to −6.8 kcal/mol for elastase in molecular docking (in silico) studies. The results suggest that the purified extracts obtained by SFE or conventional leaching extraction could act as antioxidant and antiaging ingredients for cosmeceutical applications.

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Section: Introductionmentioning

confidence: 99%

Black Bean (Phaseolus vulgaris L.) Polyphenolic Extract Exerts Antioxidant and Antiaging Potential

et al. 2021

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“…In a separate description, panduratin A has been reported for its antioxidant, antiobesity, anti-inflammatory, and antimicrobial activities [ 111 , 112 , 113 , 114 ]. Even though boesenbergin has been reported to be highly hepatoxic, it has been demonstrated to exhibit anti-inflammatory, antioxidant, and anticancer activities [ 115 ].…”

Section: Naturally Occurring Chalconesmentioning

confidence: 99%

Chalcone Scaffolds, Bioprecursors of Flavonoids: Chemistry, Bioactivities, and Pharmacokinetics

Rudrapal¹,

Khan

Dukhyil

et al. 2021

Molecules

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Chalcones are secondary metabolites belonging to the flavonoid (C6-C3-C6 system) family that are ubiquitous in edible and medicinal plants, and they are bioprecursors of plant flavonoids. Chalcones and their natural derivatives are important intermediates of the flavonoid biosynthetic pathway. Plants containing chalcones have been used in traditional medicines since antiquity. Chalcones are basically α,β-unsaturated ketones that exert great diversity in pharmacological activities such as antioxidant, anticancer, antimicrobial, antiviral, antitubercular, antiplasmodial, antileishmanial, immunosuppressive, anti-inflammatory, and so on. This review provides an insight into the chemistry, biosynthesis, and occurrence of chalcones from natural sources, particularly dietary and medicinal plants. Furthermore, the pharmacological, pharmacokinetics, and toxicological aspects of naturally occurring chalcone derivatives are also discussed herein. In view of having tremendous pharmacological potential, chalcone scaffolds/chalcone derivatives and bioflavonoids after subtle chemical modification could serve as a reliable platform for natural products-based drug discovery toward promising drug lead molecules/drug candidates.

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“…Several previous studies in the field of modern medicine have reported that chronic exposure to UV irradiation can induce thickening, keratinization, and unclear layering of the skin epidermis, 2 as well as proliferation, distortion, or even breakage of elastic fibers in the dermis 3,4 . Furthermore, long‐term UV exposure causes retrogression and excessive deposition of abnormal collagen fibers, 5,6 thereby leading to skin photoaging manifested by increased wrinkles, thickened epidermis, redness, swelling, and stains 7 …”

Section: Introductionmentioning

confidence: 99%

“…3,4 Furthermore, long-term UV exposure causes retrogression and excessive deposition of abnormal collagen fibers, 5,6 thereby leading to skin photoaging manifested by increased wrinkles, thickened epidermis, redness, swelling, and stains. 7 Presently, almost all of the available skin care products that are used to reduce photoaging damage contain chemically synthesized additives. Therefore, skin allergies and other skin problems…”

mentioning

confidence: 99%

Optimization of the saffron compound essence formula and its effect on preventing skin photoaging

Liu

Jiang

et al. 2021

J of Cosmetic Dermatology

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Skin photoaging is mainly induced by long-term exposure to ultraviolet (UV) irradiation, thereby leading to wrinkles, pigmentation, looseness, and roughness of skin appearance, which seriously affects the appearance. 1 Several previous studies in the field of modern medicine have reported that chronic exposure to UV irradiation can induce thickening, keratinization, and unclear layering of the skin epidermis, 2 as well as proliferation, distortion, or even breakage of elastic fibers in the dermis. 3,4 Furthermore, long-term UV exposure causes retrogression and excessive deposition of abnormal collagen fibers, 5,6 thereby leading to skin photoaging manifested by increased wrinkles, thickened epidermis, redness, swelling, and stains. 7 Presently, almost all of the available skin care products that are used to reduce photoaging damage contain chemically synthesized additives. Therefore, skin allergies and other skin problems

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Oral intake of Boesenbergia pandurata extract improves skin hydration, gloss, and wrinkling: A randomized, double‐blind, and placebo‐controlled study

Abstract: These results suggest that BPE can be used as a nutraceutical or nutricosmetic material for improving human skin hydration, gloss, and wrinkling.

Cited by 21 publications

References 27 publications

Black Bean (Phaseolus vulgaris L.) Polyphenolic Extract Exerts Antioxidant and Antiaging Potential

Black Bean (Phaseolus vulgaris L.) Polyphenolic Extract Exerts Antioxidant and Antiaging Potential

Chalcone Scaffolds, Bioprecursors of Flavonoids: Chemistry, Bioactivities, and Pharmacokinetics

Optimization of the saffron compound essence formula and its effect on preventing skin photoaging

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