Oral findings associated with primary hyperoxaluria type I

Mitsimponas, K.T.; Wehrhan, T.; Falk, Sandor; Wehrhan, Falk; Neukam, Friedrich Wilhelm; Schlegel, K.

doi:10.1016/j.jcms.2012.01.009

Cited by 12 publications

(18 citation statements)

References 45 publications

(83 reference statements)

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“…Periodontal disease and external root resorption have been described in all case reports, 2-12 whereas radiolucencies in the jaws have been more rarely observed. 5,7,8,10 Among the latter 4 case reports, only 1 described a patient with primary hyperoxaluria and secondary hyperparathyroidism complicating an endstage renal failure. 7 In case reports in which a histopathologic examination was performed, 2-11 oxalate crystals were found in the alveolar bone, dental pulp, dentin, periodontal ligament, oral mucosa, and salivary glands.…”

Section: Discussionmentioning

confidence: 99%

Oral Manifestations of Chronic Renal Failure Complicating a Systemic Genetic Disease: Diagnostic Dilemma. Case Report and Literature Review

Benmoussa

Renoux

Radoï

2015

Journal of Oral and Maxillofacial Surgery

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Section: Discussionmentioning

confidence: 99%

Oral Manifestations of Chronic Renal Failure Complicating a Systemic Genetic Disease: Diagnostic Dilemma. Case Report and Literature Review

Benmoussa

Renoux

Radoï

2015

Journal of Oral and Maxillofacial Surgery

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“…Biopsies of peripheral nerves reveal crystal deposition within axons and epineural blood vessels with associated axon loss and demyelination 61–64 . Oxalosis may also involve teeth 65–67 and blood vessels of the heart and liver 68, 69 .…”

Section: Signs and Symptomsmentioning

confidence: 99%

Update on Oxalate Crystal Disease

et al. 2013

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Oxalate arthropathy is a rare cause of arthritis characterized by deposition of calcium oxalate crystals within synovial fluid. This condition typically occurs in patients with underlying primary or secondary hyperoxaluria. Primary hyperoxaluria constitutes a group of genetic disorders resulting in endogenous overproduction of oxalate, whereas secondary hyperoxaluria results from gastrointestinal disorders associated with fat malabsorption and increased absorption of dietary oxalate. In both conditions oxalate crystals can deposit in the kidney leading to renal failure. Since oxalate is primarily renally eliminated, it accumulates throughout the body in renal failure, a state termed oxalosis. Affected organs can include bones, joints, heart, eyes and skin. Since patients can present with renal failure and oxalosis before the underlying diagnosis of hyperoxaluria has been made, it is important to consider hyperoxaluria in patients who present with unexplained soft tissue crystal deposition. The best treatment of oxalosis is prevention. If patients present with advanced disease, treatment of oxalate arthritis consists of symptom management and control of the underlying disease process.

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“…Although teeth are mineralized tissues, oral findings associated with PH are rarely described: less than a dozen case reports have been published since 1973 [27], including bone resorption in the jaws, aggressive external root resorption, rapidly progressive dental mobility, dental pain, deposits in the periodontium, and alveolar bone loss [28][29][30]. Tooth resorption may be due to chronic inflammation but also to the presence of osteoclast-like cells surrounding the oxalate crystal deposit, as described in bone biopsies from patients with PH and as detailed below [30].…”

Section: Dental Abnormalities In Ph Patientsmentioning

confidence: 99%

“…When observed in polarized light, these deposits were green and presented a birefringent aspect, corresponding to calcium oxalate crystals [30]. Since CLKT has been proven successful in patients with PH, one can imagine an increased frequency of oral problems in PH patients in the future; there are no specific guidelines for dental care in patients with PH, but in addition to periodontal therapy and maintenance of a meticulous oral hygiene, splinting of the mobile teeth can be a therapeutic option [28]. Fig.…”

Section: Dental Abnormalities In Ph Patientsmentioning

confidence: 99%

Bone impairment in primary hyperoxaluria: a review

2015

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Deposition of calcium oxalate crystals in the kidney and bone is a hallmark of primary hyperoxaluria (PH). Since the bone compartment can store massive amounts of oxalate, patients present with recurrent low-trauma fractures, bone deformations, severe bone pains, and specific oxalate osteopathy on X-ray. Bone biopsy from the iliac crest displays specific features such as oxalate crystals surrounded by a granulomatous reaction corresponding to an invasion of bone surface by macrophages. The objective of this manuscript is therefore to provide an overview of bone impairment in PH, by reviewing the current literature on bone and dental symptoms as well as imaging techniques used for assessing bone disease.

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Oral findings associated with primary hyperoxaluria type I

Cited by 12 publications

References 45 publications

Oral Manifestations of Chronic Renal Failure Complicating a Systemic Genetic Disease: Diagnostic Dilemma. Case Report and Literature Review

Oral Manifestations of Chronic Renal Failure Complicating a Systemic Genetic Disease: Diagnostic Dilemma. Case Report and Literature Review

Update on Oxalate Crystal Disease

Bone impairment in primary hyperoxaluria: a review

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