Oral Chinese Herbal Medicine as Maintenance Treatment after Chemotherapy for Advanced Non-Small-Cell Lung Cancer: A Systematic Review and Meta-Analysis

Wang, Q.; Wang, S.F.; Jiao, Lijing; Zhang, R.X.; Zhong, Yucheng; Zhang, J.; Xu, Luwei

doi:10.3747/co.24.3561

Cited by 33 publications

(23 citation statements)

References 34 publications

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“…Today, TCM is an accepted and important part of cancer treatment alongside Western medicine in China and is gaining acceptance in the United States. (Liu et al, 2015;Ling et al, 2018;Wang Q. et al, 2017;Xiang et al, 2019). Complementary medicine has increased 30% in National Cancer Institute (NCI) designated cancer centers, and acupuncture is represented in 73% of those centers, herbal medicine in 66.7% (Yun et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Chinese Herbal Medicine and Its Regulatory Effects on Tumor Related T Cells

Hoffman

et al. 2020

Front. Pharmacol.

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Traditional Chinese medicine is an accepted and integral part of clinical cancer management alongside Western medicine in China. However, historically TCM physicians were unaware of the chemical constituents of their formulations, and the specific biological targets in the body. Through HPLC, flow cytometry, and other processes, researchers now have a much clearer picture of how herbal medicine works in conjunction with the immune system in cancer therapy. Among them, the regulation of tumor-related T cells plays the most important role in modulating tumor immunity by traditional Chinese medicine. Encouraging results have been well-documented, including an increase in T cell production along with their associated cytokines, enhanced regulation of Tregs and important T cell ratios, the formation and function of Tregs in tumor microenvironments, and the promotion of the number and function of normal T Cells to reduce conventional cancer therapy side effects. Chinese herbal medicine represents a rich field of research from which to draw further inspiration for future studies. While promising agents have already been identified, the vast majority of Chinese herbal mechanisms remain undiscovered. In this review, we summarize the effects and mechanisms of specific Chinese herbs and herbal decoctions on tumor related T cells.

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Section: Introductionmentioning

confidence: 99%

Chinese Herbal Medicine and Its Regulatory Effects on Tumor Related T Cells

Hoffman

et al. 2020

Front. Pharmacol.

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“…With the development in pharmacology, the constituents of many Chinese herbal medicines have been separated. Therefore, the mechanisms of Chinese herbal medicines for disease treatment have gradually become clear, and in recent years an increasing number of studies have applied Chinese herbal medicine in the treatment of cancer . Therefore, this study explored the effects of the herbal medicine E. prostrata extract (EPE) on oral cancer.…”

Section: Discussionmentioning

confidence: 99%

Antimetastatic effects of Eclipta prostrata extract on oral cancer cells

Liao

Chuang

Hsieh

et al. 2018

Environmental Toxicology

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Eclipta prostrata, a traditional Chinese medication, has been used for the treatment of several diseases. However, the molecular mechanism underlying the effects of Eclipta prostrata extracts (EPE) on human oral cancer cell metastasis remains unclear. We thus examined the effects of EPE on metastasis promoting proteins in oral cancer. Our results revealed that the EPE attenuated SCC-9, HSC-3, and TW2.6 cell migration and invasiveness by reducing matrix metalloproteinase (MMP)-2 enzyme activities. In addition, Western blot analysis revealed that EPE significantly reduced the levels of phosphorylated extracellular signal-regulated kinase 1/2 (ERK 1/2) but not those of c-Jun N-terminal kinase (JNK) 1/2 and p38. In conclusion, we found that EPE could inhibit oral cancer metastasis through the inhibition of MMP-2 expression. Therefore, EPE may be used to prevent the metastasis of oral cancer, and has the potential to be applied to cancer treatment.

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“…Recent reviews have suggested that adjunct CAM therapies, including acupuncture, pharmacopuncture, and herbs, have benificial effects on cancer-related symptoms, conventional treatment-associated side effects, and the response rate of the tumor. [ 27 – 34 ] However, limited cohort evidence has been published on its effects on survival and quality of life for patients being treated with TKM. The objective of this prospective cohort study is to evaluate both the effect of ACTKMT on EFS, DFS/PFS, OS, quality of life, blood test results, and telomere length and the adverse events associated with ACTKMT.…”

Section: Discussionmentioning

confidence: 99%

The effectiveness of anticancer traditional Korean medicine treatment on the survival in patients with lung, breast, gastric, colorectal, hepatic, uterine, or ovarian cancer

Bae

Kim²,

Choi

et al. 2018

Medicine

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Although anticancer traditional Korean medicine treatment (ACTKMT) is widely applied to patients with cancer together with, or in place of, conventional cancer treatment in Korea, the cohort evidence on its clinical effects is lacking. Therefore, this prospective cohort study is designed to evaluate the effect of ACTKMT on the survival and the clinical outcomes for patients being treated at an integrative oncology clinic.This is a single center, prospective cohort study of patients within 1 year after the diagnosis of primary lung, breast, gastric, colorectal, hepatic, uterine, or ovarian cancer. The event-free survival, disease-free survival/progression-free survival, the overall survival, the results of blood tests, and telomere-length information will be compared between patients receiving and patients not receiving a key ACTKMT (HangAmDan-B1, Geonchil-jung, and/or cultivated wild ginseng pharmacopuncture), and the correlation between the use of the key ACTKMT and the prognosis will be identified considering other risk factors.This study has received ethical approval from the Institutional Review Board, Dunsan Korean Medicine Hospital of Daejeon University (No. DJDSKH-16-BM-09). The results of this study will be published in a peer-reviewed journal.Clinical Research Information Service: KCT0002160.

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Oral Chinese Herbal Medicine as Maintenance Treatment after Chemotherapy for Advanced Non-Small-Cell Lung Cancer: A Systematic Review and Meta-Analysis

Abstract: BackgroundThe concept of maintenance therapy in cancer treatment is currently under debate because of modest

Cited by 33 publications

References 34 publications

Chinese Herbal Medicine and Its Regulatory Effects on Tumor Related T Cells

Chinese Herbal Medicine and Its Regulatory Effects on Tumor Related T Cells

Antimetastatic effects of Eclipta prostrata extract on oral cancer cells

The effectiveness of anticancer traditional Korean medicine treatment on the survival in patients with lung, breast, gastric, colorectal, hepatic, uterine, or ovarian cancer

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