1983
DOI: 10.1111/j.1600-0536.1983.tb04437.x
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Oral challenge with metal salts. (I). Vesicular patch‐test‐negative hand eczema

Abstract: 202 patients, 68 males and 134 females, with patch-test-negative, symmetrical vesicular hand eczema were challenged orally in a controlled study with 2.5 mg nickel, 2.5 mg chromium and 1 mg cobalt given as salts of the respective metals. Initially a mixture of the 3 metal salts was given, and if this produced a flare of the eczema, the salts were administered individually at 1 week intervals. 55 patients reacted to the mixture of salts as well as to 1 or 2 of the individual salts. 3 other patients were challen… Show more

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Cited by 44 publications
(29 citation statements)
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References 6 publications
(7 reference statements)
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“…In a similar analysis, the amount of Cr per serving of TS is added to the maximum Adequate Intake Level (as defined by the Institute of Medicine), 45 μg/day (14), then compared to the estimated dose threshold associated with ACD, 2500 μg/day (13). Tomato sauce cooked in the absence of stainless steel would comprise just over half of the maximum adequate level, with about 25μg of Cr per serving; however, well below the estimated threshold associated with ACD.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…In a similar analysis, the amount of Cr per serving of TS is added to the maximum Adequate Intake Level (as defined by the Institute of Medicine), 45 μg/day (14), then compared to the estimated dose threshold associated with ACD, 2500 μg/day (13). Tomato sauce cooked in the absence of stainless steel would comprise just over half of the maximum adequate level, with about 25μg of Cr per serving; however, well below the estimated threshold associated with ACD.…”
Section: Discussionmentioning
confidence: 99%
“…Nickel levels are compared with the Tolerable Upper Intake Level (UL) (1000 μg/day) (6) and chromium levels are compared with the lowest dose known to cause ACD, 2500 μg/day (13). …”
Section: Figurementioning
confidence: 99%
“…Indeed, ingested Ni may have consequences for the expression of skin conditions in sensitized individuals, such as flare-up of cutaneous reactions in some Ni-allergic patients (Christensen and Möller, 1975;Kaaber et al, 1978;Cronin et al, 1980;Veien et al, 1983;Hindsén et al, 2001;Gangemi et al, 2009). It should also be noted that on the other hand, experimental studies have also shown that repeated oral exposure to Ni may prevent diminish sensitization.…”
Section: Sensitizationmentioning
confidence: 99%
“…When prescribing a low nickel diet, the effect is even more disputable. Previous studies have shown that improvement of the dermatitis is seen 4–6 weeks after being on a low nickel diet 60,61 . However, a low‐nickel diet is not helpful in 100% of the cases, and certain patients would not benefit from it.…”
Section: Clinical Manifestationsmentioning
confidence: 99%
“…Foods rich in nickel include green beans, broccoli, peas, canned vegetables and spaghetti, canned fruit, dried fruit, nuts, cocoa, and chocolate 75 . Only a few patients would react to 0.5 mg nickel given as a single oral dose, while the majority of patients react to a dose of 5 mg or more 60,61,76 …”
Section: Treatment and Prevention Of Nickel Allergymentioning
confidence: 99%