Oral cancer: A multicenter study

Abstract

BackgroundTo determine the prevalence and clinicopathologic features of the oral cancer patients.Material and MethodsBiopsy records of the participating institutions were reviewed for oral cancer cases diagnosed from 2005 to 2014. Demographic data and site of the lesions were collected. Sites of the lesion were subdivided into lip, tongue, floor of the mouth, gingiva, alveolar mucosa, palate, buccal/labial mucosa, maxilla and mandible. Oral cancer was subdivided into 7 categories: epithelial tumors, salivary gland tumors, hematologic tumors, bone tumors, mesenchymal tumors, odontogenic tumors, and others. Data were analyzed by descriptive statistics using SPSS software version 17.0.ResultsOf the 474,851 accessioned cases, 6,151 cases (1.30%) were diagnosed in the category of oral cancer. The mean age of the patients was 58.37±15.77 years. A total of 4,238 cases (68.90%) were diagnosed in males, whereas 1911 cases (31.07%) were diagnosed in females. The male-to-female ratio was 2.22:1. The sites of predilection for oral cancer were tongue, labial/buccal mucosa, gingiva, palate, and alveolar mucosa, respectively. The three most common oral cancer in the descending order of frequency were squamous cell carcinoma, non-Hodgkin lymphoma and mucoepidermoid carcinoma.ConclusionsAlthough the prevalence of oral cancer is not high compared to other entities, oral cancer pose significant mortality and morbidity in the patients, especially when discovered late in the course of the disease. This study highlights some anatomical locations where oral cancers are frequently encountered. As a result, clinicians should pay attention to not only teeth, but oral mucosa especially in the high prevalence area as well since early detection of precancerous lesions or cancers in the early stage increase the chance of patient being cured and greatly reduce the mortality and morbidity. This study also shows some differences between pediatric and elderly oral cancer patients as well as between Asian and non-Asian oral cancer patients. Key words:Oral cancer, prevalence, clinic-pathologic features, retrospective study.

Conhecimento de Universitários da Área da Saúde sobre o Câncer de Cavidade Oral

“…De acordo com Goldemberg et al 9 , os indicadores epidemiológicos do CCO estão relacionados desde a falta de educação até o diagnóstico tardio da doença. Portanto, os profissionais de saúde devem estar a par das evidências epidemiológicas 11,12 . Nos países nórdicos, foi realizado um estudo de coorte que comparou o risco de câncer de boca e faringe em diferentes ocupações, com dados coletados de 14,9 milhões de pessoas, sendo encontrados 28.623 casos de câncer de língua, cavidade oral e faringe.…”

“…Ainda que esteja bem estabelecido o fato de a alta ingestão de legumes frescos, frutas, peixes e frutos ser preventiva contra o câncer bucal 12,20 , os achados do presente estudo corroboram os estudos que utilizaram o questionário elaborado pela teoria de resposta ao item. Canevese et al 20 observaram que houve indivíduos que não creditam uma dieta saudável a um fator de prevenção para a doença.…”

“…Ainda que o câncer oral não seja o mais prevalente, tem um prognóstico de mortalidade e principalmente de morbidade nos pacientes, essencialmente quando descoberto tardiamente após o aparecimento dos sintomas 12,28 . O diagnóstico tardio, geralmente quando os tumores já estão mais profundos, possui a probabilidade de ter o estágio mais avançado da doença.…”

Prevalence of human papillomavirus type 16 in persistent oral lesions arising in patients with tobacco, areca nut, and alcohol habits

“…HPV16 is the high-risk type commonly reported in HPV-positive head and neck cancer cases. 55 Following an international casecontrol study conducted by the IARC, HPV16 is highly prevalent in HPV-positive cancer cases of the oral cavity and orophayrnx 56 and preponderantly consorts with the premalignant and malignant cellular landscape of oral subsites. 57 In the present study, we found that 50% of OSCC POLs showed 208-bp HPV16-E6 amplicon, while 53% of non-OSCC POLs were HPV16 DNA positive.…”

Oral Cancer Awareness Among Medical & Dental Students of Bahria University Medical and Dental College

“…6,7 The most commonly affected sites involving the mouth are the floor and the lateral border of the tongue. 8 In American and European countries, drinking alcohol and smoking tobacco are documented as the causative agents for oral cancer 9 but within developing Asian countries the main carcinogenic influence are betel nut, areca nut and other addictives. World Health Organization (WHO) also states that alcohol consumption, tobacco and other risk factors have 43% role in all cancer deaths.…”