Oral and Maxillofacial Viral Infections

Porter, Stephen R.; Leão, Jair Carneiro; Gueiros, Luiz Alcino Monteiro

doi:10.1007/978-3-319-28100-1_44-1

Cited by 4 publications

(3 citation statements)

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“…8 HSV merupakan famili Herpesviridae, virus DNA, virus ini menginfeksi 60%-95% dari populasi. 9,10,11 HSV-1 sering dikaitkan dengan infeksi oral dan perioral, sedangkan HSV-2 umumnya menyebabkan infeksi genital. 9,12 HSV-1 sangat menular dan endemis di seluruh dunia, tertular saat kanak-kanak serta mengakibatkan gingivostomatitis herpetika primer.…”

Section: Pendahuluanunclassified

“…10 Pasien pada kasus ini tidak diberikan antivirus karena infeksi HSV-1 telah berlangsung lebih dari 2 minggu dan kondisi gingivostomatitis herpetik primer pada pasien yang sudah mengalami penyembuhan. 10,11,31,32,33 Mekanisme kerja obat antivirus bergantung pada obat antivirus yang digunakan, untuk infeksi HSV-1 biasanya menggunakan asiklovir. Mekanisme kerja dari asiklovir yaitu menghambat sintesis DNA virus, melalui dua mekanisme.…”

Section: Pembahasanunclassified

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Tatalaksana infeksi herpes simpleks virus tipe-1 dan necrotizing ulcerative stomatitis pada anak dengan anemia aplastikManagement of type-1 herpes simplex virus infection and necrotising ulcerative stomatitis in children with aplastic anaemia

Lefaan¹,

Hidayat

Nur’aeny

2022

J Ked Gi Unpad

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ABSTRAKPendahuluan: Necrotizing ulcerative stomatitis (NUS) merupakan penyakit inflamasi pada rongga mulut, ditandai oleh ulser nekrosis akut, berkembang cepat serta menyebabkan kerusakan masif pada jaringan. NUS dapat berkembang dari kondisi necrotizing ulcerative gingivitis (NUG) dan necrotizing ulcerative periodontitis (NUP). NUS dapat disertai infeksi lain, salah satunya infeksi herpes simplex tipe 1 (HSV-1). Infeksi HSV-1 dan NUS pada anak dengan anemia aplastik jarang ditemukan. Anemia aplastik merupakan kelainan hematologi, ditandai dengan hipoplastik/aplasia sumsum tulang dan pansitopenia, sehingga menurunkan resistensi host terhadap infeksi. Gingivostomatitis herpetik primer memudahkan perkembangan bakteri komensal seperti bakteri Fusiform, Spirochetes dan Pseudomonas aeruginosa menjadi patogen pada kondisi imunosupresif sehingga meningkatkan progresivitas penyakit periodontal menjadi NUS. Tujuan laporan kasus ini adalah menjelaskan tatalaksana infeksi HSV-1 dan NUS pada anak dengan anemia aplastik. Laporan kasus: Seorang anak perempuan usia 3 tahun dengan diagnosis anemia aplastik dan febrile neutropenia, dirujuk oleh divisi Hematologi-onkologi anak Rumah Sakit Dr. Hasan sadikin (RSHS) Bandung dengan keluhan pembengkakan pada bibir dan stomatitis. Hasil pemeriksaan darah menunjukan adanya pansitopenia dan pemeriksaan anti HSV-1 IgG reaktif. Diagnosis terkait kondisi bibir dan mulut pasien adalah Infeksi HSV-1 dan NUS. Tatalaksana yang dilakukan adalah debridement dengan Hidrogen peroksida 1,5% (H2O2 1,5%), kontrol plak dengan chlorhexidine digluconate 0,12% dan multivitamin. Pembengkakan mulai membaik setelah 3 hari debridement serta memberikan hasil yang signifikan setelah 1 bulan perawatan. Simpulan: Tatalaksana berupa peningkatan oral hygiene dan terapi antiseptik dapat memperbaiki kondisi infeksi HSV-1 dan NUS, khususnya pada pasien dengan kondisi imunosupresif seperti anemia aplastik.Kata kunci: febrile neutropenia; stomatitis; herpes simpleks; anemia; spirochetes ABSTRACTIntroduction: Necrotising ulcerative stomatitis (NUS) is an inflammatory disease of the oral cavity, characterised by acute necrotising ulcers, proliferating, and causing massive tissue damage. NUS can be developed from necrotising ulcerative gingivitis (NUG) and necrotising ulcerative periodontitis (NUP). NUS can be accompanied by other infections, such as herpes simplex type 1 (HSV-1) infection. However, HSV-1 and NUS infections in children with aplastic anaemia are rare. Aplastic anemia is a haematological disorder characterised by hypoplastic/bone marrow aplasia and pancytopenia, reducing the host's resistance to infection. Primary herpetic gingivostomatitis facilitates the development of commensal bacteria such as Fusiform bacteria, Spirochetes and Pseudomonas aeruginosa to become pathogens under immunosuppressive conditions, thereby increasing the progression of periodontal disease to NUS. This case report aims to describe the management of HSV-1 and NUS infections in children with aplastic anemia. Case report: A 3-year-old female child diagnosed with aplastic anaemia and febrile neutropenia was referred by the paediatric haematology-oncology division of Dr Hasan Sadikin Hospital (RSHS) Bandung with complaints of swelling of the lips and stomatitis. Blood test results showed pancytopenia and reactive anti-HSV-1 IgG examination. The diagnosis related to the patient's lips and mouth condition was HSV-1 and NUS infection. The treatment is debridement with 1.5% hydrogen peroxide (H2O2 1.5%), plaque control with 0.12% chlorhexidine digluconate and multivitamins. After three days of debridement, the swelling started to improve and gave significant results after one month of treatment. Conclusion: Management of improving oral hygiene and antiseptic therapy can improve the condition of HSV-1 and NUS infections, especially in patients with immunosuppressive conditions such as aplastic anemia.Keywords: febrile neutropenia; stomatitis; herpes simplex; anaemia; spirochetes

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Section: Pendahuluanunclassified

Section: Pembahasanunclassified

Tatalaksana infeksi herpes simpleks virus tipe-1 dan necrotizing ulcerative stomatitis pada anak dengan anemia aplastikManagement of type-1 herpes simplex virus infection and necrotising ulcerative stomatitis in children with aplastic anaemia

Lefaan¹,

Hidayat

Nur’aeny

2022

J Ked Gi Unpad

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“…Infection by oncogenic or no oncogenic viruses can cause several lesions in the oral mucosa. 5,6 For example, human papilloma virus is responsible for papillomata's lesions, especially in the palatal…”

Section: Introductionmentioning

confidence: 99%

A Sketch on Oral Mucosal Lesion Presenting in a Rural Tertiary Care Hospital in Bangladesh

Islam¹,

Sarker

Jebin³

et al. 2021

Update Dent. Coll. j

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Background: Oral mucosal lesion (OML) is defined as any abnormal alteration in color, surface aspect, swelling, or loss of integrity of the oral mucosal surface. Some oral mucosal lesions are benign and require no treatment but some may present with significant pathology. Several oral potential disorders frequently progress into malignancy Objective: The present study was carried out to assess the pattern of various oral cavity lesions of patients attending in a regional tertiary care hospital in northern area of Bangladesh. Materials and Methods: This prospective cross-sectional study was carried out in the Department of Dentistry in collaboration with department of Pathology of Khwaja Yunus Ali Medical College and Hospital, Sirajgonj, Bangladesh during the period of one year from December 2016 to December 2017. An elaborate schedule was prepared before undertaking the study. A total of 73 patients in the Dental OPD of the hospital presenting with oral lesion for more than 3 weeks were randomly selected. An incisional biopsy was taken from all patients and histological examinations were done. The collected data were analyzed using SPSS (V-20) and MS Excel. Results: Most common site of oral lesion is Buccal Mucosa (36.99%), then supraglotic region (26.03%), lower lip 6.85%, gingiva 5.48%, anterior palate and oral flor 4.11% each. Most of the lesion was Squamous cell carcinoma (58%), then lichen planus, leukoplakia, inflammatory lesion, pyogenic granuloma and verrucous carcinoma, each of them was around 5% of lesion. Conclusion: The epidemiological data on the prevalence of oral lesion is an important determinant in planning appropriate levels of services and further studies are required to provide accurate estimates of the treatment need in Bangladeshi population with oral lesion. Update Dent. Coll. j: 2021; 11(2): 4-9

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Insight in prevalent infectious diseases viral and dentistry

Rastogi

2022

IDJSR

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There are many diseases that affect individuals. Of these most contagious and most easily communicable are viral infections. They start with cold, cough, sneezing and influenza conditions. If proper precautions are not taken they are spread from person to person. These viral diseases have dental/oral lesions. If dentist are aware of these, they can definitely early diagnose and treat them. It is essential that viral diseases and their oral lesions are examined so that necessary steps can be taken. In last 2 years, some viral infections have come up that need correct treatment planning for great success.

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Oral and Maxillofacial Viral Infections

Cited by 4 publications

References 56 publications

Tatalaksana infeksi herpes simpleks virus tipe-1 dan necrotizing ulcerative stomatitis pada anak dengan anemia aplastik<p></p>Management of type-1 herpes simplex virus infection and necrotising ulcerative stomatitis in children with aplastic anaemia<p>

Tatalaksana infeksi herpes simpleks virus tipe-1 dan necrotizing ulcerative stomatitis pada anak dengan anemia aplastik<p></p>Management of type-1 herpes simplex virus infection and necrotising ulcerative stomatitis in children with aplastic anaemia<p>

A Sketch on Oral Mucosal Lesion Presenting in a Rural Tertiary Care Hospital in Bangladesh

Insight in prevalent infectious diseases viral and dentistry

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